Seasonal effect of Brazilian propolis on seric biochemical variables

Abstract

Propolis has been the subject of recent scientific investigation due to its biological properties, such as antibiotic, antiinflammatory, anesthetic, healing, immunomodulatory, antioxidant, and carcinostatic. The purpose of this study was to analyze the biochemical profile of propolis-treated rats to observe whether propolis might lead to side effects after administration. Evaluation of total protein, glucose, urea, creatinine, triglycerides, cholesterol, and HDL-cholesterol concentrations and determination of aminotransferases (AST and ALT) and lactic dehydrogenase (LDH) in propolis-treated rat serum were performed. The seasonal effect on propolis activity was also analyzed, considering the biochemical variables evaluated. The lack of clinically important changes in seric biochemical variables is probably because propolis showed no biological side effects under these conditions. A possible seasonal effect on the biochemical determinations was not observed

Ação terapêutica da própolis em lesões cutâneas

“…Martinez Garcia et al (14) ;Duailibe et al (15) Clinical -Antimicrobial action Azevedo et al (4) ;Santos et al (11) ; Lofuto et al (35) Clinical -Therapeutic action in wound healing Peruchi et al (2) ;Park et al (3) ;Vargas et al (5) ; Fernandes Júnior et al (6) ; Silva et al (7) ;Sforcin et al (8) ; Sforcin et al (9) ;Oliveira et al (10) ; Auricchio et al (35) ; Fernandes Júnior et al (17) ;Machado et al (18) ;Longhini et al (19) ;Sawaya et al (20) ;Fernandes et al (21) ;Fernandes Júnior et al ( 22) ; Muli et al (23) ;Gebara et al (24) ;Fernandes Júnior et al (25) ;Bianchini et al (26) ;Gonçales et al (27) ;Dantas et al (28) ; Ayres et al (29) ;Orsi et al (30) ;Orsi et al (31) ;Sforcin et al (32) ;Sforcin et al (33) ;Orsi et al (34) ; Fernandes Júnior et al (36) ;Fernandes et al (37) ; Araújo et al (38) Experimental -Antimicrobial action Rahal et al (16) Experimental -Therapeutic action in wound healing (1) . Another study, which used propolis ointment on 22 chronic wounds, of which 11 were venous ulcers, seven pressure ulcers, two diabetic ulcers, and two post-trauma injuries, found that necrotic tissue was present in 14 (8.2%) during tissue assessment process.…”

“…These properties are found to be associated with its chemical composition, which has, until this moment, about 200 compounds already identified, of which the main groups are flavonoids, fat acids, alcohols, amino acids, vitamins and minerals (2,(4)(5)(6)(7)(8)(9)(10)(11) .…”

Uso de própolis e ácido ascórbico na criopreservação do sêmen caprino

“…No caso da própolis, além de apresentar inúmeras substâncias em sua composição e em diferentes concentrações (Pereira et al, 2002;Sforcin et al, 2002), ainda não foi elucidada sua verdadeira ação antioxidante in vitro sobre os espermatozoides. Apesar da baixa concentração nos diluentes, alguma substância presente na própolis pode ter sido tóxica às células, de modo que a baixa viabilidade espermática foi verificada após o…”

“…No homem, vários trabalhos têm sido publicados divulgando e revisando as propriedades biológicas da própolis, como atividade antimicrobiana, antifúngica, antiprotozoária, hepatoprotetoras, antitumoral, cicatrizante, anti-inflamatória, antiviral, antioxidante, entre outras (Pereira et al, 2002;Sforcin et al 2002). Oliveira et al (2007) estudaram o efeito da adição de própolis ao meio diluidor em diferentes concentrações (0,25 e 0,5%) e sua influência nas características físicas do sêmen equino resfriado a 5 o C e concluíram que a própolis não teve efeitos benéficos sobre as características físicas do sêmen equino resfriado a 5 o C.…”

Propolis effect on streptozotocin-induced diabetic rats

“…Nowadays, propolis has attracted researchers' interest due to its several therapeutic activities, such as immunomodulatory, antitumor, antimicrobial, anti-inflammatory and antioxidant effects, among others (1). After its administration to animals or to humans propolis does not appear to present side effects (2,3).…”