2000
DOI: 10.1590/s0104-79302000000200008
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Abstract: It has been previously shown that the crude venom of Tityus serrulatus can cause convulsions. This study was designed to investigate the neurotoxic effects of B, C, G, and K fractions isolated from this venom. Intravenous injection of these fractions in mice (0.6 - 6.0 mg/kg body weight) showed that the C fraction is a potent convulsant and G fraction decreased the threshold for tonic hand limb extension elicited by transauricular electroshock. Unilateral injection of B, C, and K fractions, but not G fraction,… Show more

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Cited by 12 publications
(2 citation statements)
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“…The behavioral alterations are time dependant. Corroborating with previous studies leaded with fractions of T. serrulatus venom Carvalho et al, 2000) or fractions isolated from T. bahiensis (Lourenço et al, 2002), the subcutaneous administration of H. gentili crude venom decreased locomotion and rearing frequencies and increased the time of immobility and grooming of the animals tested 30 min and 3 h post injection. Ambulation and rearing can be respectively regarded as indicators of locomotor activity and exploratory behavior, whereas grooming and immobility are positively correlated with fear or emotionality (Archer, 1973;Barros et al, 1994;Bhattacharya, 1994;Doyle and Yule, 1959;Eidman et al, 1990;Henderson, 1970) Because it has been reported that high emotionality inhibits exploration (Archer, 1973), thus the diminished exploratory behavior can be a consequence of the H. gentili venom increased emotionality.…”
Section: Discussionsupporting
confidence: 80%
“…The behavioral alterations are time dependant. Corroborating with previous studies leaded with fractions of T. serrulatus venom Carvalho et al, 2000) or fractions isolated from T. bahiensis (Lourenço et al, 2002), the subcutaneous administration of H. gentili crude venom decreased locomotion and rearing frequencies and increased the time of immobility and grooming of the animals tested 30 min and 3 h post injection. Ambulation and rearing can be respectively regarded as indicators of locomotor activity and exploratory behavior, whereas grooming and immobility are positively correlated with fear or emotionality (Archer, 1973;Barros et al, 1994;Bhattacharya, 1994;Doyle and Yule, 1959;Eidman et al, 1990;Henderson, 1970) Because it has been reported that high emotionality inhibits exploration (Archer, 1973), thus the diminished exploratory behavior can be a consequence of the H. gentili venom increased emotionality.…”
Section: Discussionsupporting
confidence: 80%
“…Crude venom of Tityus serrulatus scorpion, as well its toxins, has already been extensively studied (Arantes et al, 1989;Carvalho et al, 1998Carvalho et al, , 2000Conceição et al, 2005;Dorce and Sandoval, 1994;Life Sciences 91 (2012) Massensini et al, 1998;Nencioni et al, 2000Nencioni et al, , 2003Possani et al, 1991;Revelo et al, 1996). On the other hand, few reports are available in the literature regarding the venom of the scorpion Tityus bahiensis, and the majority concern immunological effects for serum production (Nishikawa et al, 1994) or the purification and sequencing of the toxins that compose it (Becerril et al, 1996(Becerril et al, , 1997Trequattrini et al, 1995).…”
Section: Introductionmentioning
confidence: 99%