EFFECTS OF FORMALINIZATION ON THE IMMUNOPHARMACOLOGICAL CHARACTERISTICS OF THE VENOM OF THE Tityus SCORPIONS AND CROSSREACTIVITY BETWEEN THESE VENOMS

Parrilla-Álvarez, Pedro; ́Suze, G. D; Quiroga, María Isabel; Rodrı́guez-Acosta, Alexis; Sevcik, Carlos

doi:10.1590/s0104-79301999000100018

Cited by 2 publications

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“…In the current work the Tityus discrepans venom was obtained from 42 scorpions, whose venom dry weight yield was 51.7 mg, which represents 1.22 mg of venom per milked scorpion. Similar results were recorded (16), when milking, under the same conditions, 92 T. caripiensis scorpions, obtaining a dry weight of venom of 96.6 mg that represented 1.05 mg of venom per milked scorpion. Likewise, these data correlated with those described for the scorpion T. pachyurus from Colombia, which gave a yield between 0.3 and 1.0 mg of venom per specimen (17).…”

Section: Discussionsupporting

confidence: 84%

Clinical cardiac alterations and hemostatic toxicities caused by scorpion (Tityus discrepans) venom and its purified fractions on zebrafish (Danio rerio) larvae

et al. 2021

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Envenomation by the Venezuelan scorpion Tityus discrepans is typified by local and systemic alterations. The current work investigated the in vivo hemostatic processes, cardiac dysfunction and tissue destruction triggered by Tityus discrepans purified toxins 1 (3 kDa) and 2 (5 kDa) fractions. These fractions were obtained by C-18-HPLC chromatography. The hemostatic and cardiovascular toxicities in zebrafish of both fractions was assessed by means of specific phenotypic expressions and larvae behavior at 5, 15, 30, 40 and 60 min post-venom-treatment. The Tityus discrepans venom fractions 1 and 2 produced disseminated intravascular coagulation (presence of thrombus) in the central vein of the larva, heart rate/rhythm alterations, and necrotic events in more than 90% of all the larvae under their action. The outcomes have established the potential hemostatic and cardiovascular toxicities by Tityus discrepans venom, alerting on the possibility of cardiovascular injuries and thromboembolism in humans after scorpion stings envenomation.

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Section: Discussionsupporting

confidence: 84%

Clinical cardiac alterations and hemostatic toxicities caused by scorpion (Tityus discrepans) venom and its purified fractions on zebrafish (Danio rerio) larvae

et al. 2021

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An epidemiological review of scorpion stings in Venezuela: the Northeastern region

Sousa¹,

Parrilla-Álvarez

Quiroga³

2000

J. Venom. Anim. Toxins

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In Venezuela, the restricted manner of works on scorpion envenoming has contributed little to the real magnitude and knowledge of this subject in our country. The lack of basic scorpiofauna knowledge, distribution, clinical manifestations, and especially of specific treatments justify multidisciplinary studies. The purpose of these studies is to obtain information that allows the elaboration of a preventive plan. This paper demonstrates the magnitude of scorpion envenomings in Venezuela

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EFFECTS OF FORMALINIZATION ON THE IMMUNOPHARMACOLOGICAL CHARACTERISTICS OF THE VENOM OF THE Tityus SCORPIONS AND CROSSREACTIVITY BETWEEN THESE VENOMS

Cited by 2 publications

References 0 publications

Clinical cardiac alterations and hemostatic toxicities caused by scorpion (Tityus discrepans) venom and its purified fractions on zebrafish (Danio rerio) larvae

Clinical cardiac alterations and hemostatic toxicities caused by scorpion (Tityus discrepans) venom and its purified fractions on zebrafish (Danio rerio) larvae

An epidemiological review of scorpion stings in Venezuela: the Northeastern region

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