Pesquisa clínica como estratégia de desenvolvimento em saúde

Dainesi, Sonia Mansoldo; Goldbaum, Moisés

doi:10.1590/s0104-42302012000100002

Cited by 27 publications

(22 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other statistics show that annually 60 million people suffer from some type of trauma. In 2010, 23,960 Brazilians died as a result of traumatic injuries during the period of stay in health institutions of the Unified Health System (SUS), the main types of trauma being homicides, followed by traffic accidents 2,3,6 .…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Perfil das dissertações e teses brasileiras acerca do trauma: uma pesquisa documental

Salvador¹,

Alves²,

Martins³

et al. 2012

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

show abstract

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Perfil das dissertações e teses brasileiras acerca do trauma: uma pesquisa documental

Salvador¹,

Alves²,

Martins³

et al. 2012

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

show abstract

“…In areas such as oncology and inflammatory diseases, patients who participate in studies for new drugs for their illnesses benefit from it, because sometimes there is still no other therapy available; 16 Danesi and Goldbaum 17 point out that "about two billion people in the world are in need of essential drugs", which should be the responsibility of the State, although the pharmaceutical industry shares this responsibility through the development of new drugs which, in its own way, has contributed to advances in the quality of life of patients. 17 However, the main attractions indicated by the researchers in our sample were: updating their knowledge and that of the team involved, additional income for the team, maintaining ties with national and international industry, funding for the center/ institution, ties with international research centers and access to medication and devices not available in Brazil. The factors above were cited more than 65% for each sample, including principal investigators and subinvestigators, given that the two most significant citations were "additional income for the team" and the "funding for the center/institution", both with 86.2%, as shown in the results.…”

Section: Discussionmentioning

confidence: 93%

Sponsored multicentric clinical research conducted in Brazil in the respiratory area - losses and gains

Carvalho

Nascimento

Fonseca

et al. 2016

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Objective: To evaluate the sponsored centers for clinical trial in the respiratory care setting in Brazil: profile; logistics and structure. Methods: Principal investigators (29) and subinvestigators (30) of 39 research centers completed the questionnaires that addressed personal identification and training of researchers, the centers' facilities and advantages and/or disadvantages of performing sponsored trials. Results: 75.6% of the centers were located in southern and southeastern Brazil. Most principal investigators were men with a mean age of 53.4 years. The clinical trials in the respiratory care setting focus on asthma and chronic obstructive pulmonary disease (COPD). 80% of the researchers cited delay of the Conep and Anvisa as a barrier to performing research. The advantages of participating in clinical trials were updating knowledge of the researcher and the team, and additional income for the team. The main disadvantages mentioned by the researchers included low financial compensation for the performed workload, and time availability. The median number of professionals per research center was six people, predominantly physicians. Conclusion:The number of research centers in the respiratory care setting in Brazil is still relatively small. The teams have good training for performing the clinical trials. Asthma and COPD are the most studied diseases in sponsored clinical trials. The main barrier is delay by the Conep and Anvisa. The factors that lead investigators to participate range from being updated along with the team, to site and staff financial issues; the main disadvantage is the low compensation for the required workload demand.

show abstract

“…Physical, physiological, and genetic factors may affect response to treatment. Thus, the inclusion of participants from several countries is fundamental for population representation 24,25 . In addition, the use of placebos in clinical trials is related to the state of economic and social vulnerability of countries and their population, and, consequently, the scarcity or limitation of access to basic medicines 23 .…”

Section: Vulnerability and The Double Standardmentioning

confidence: 99%

Autonomia, consentimento e vulnerabilidade do participante de pesquisa clínica

Cosac

2017

Rev. Bioét.

View full text Add to dashboard Cite

The present study is a bibliographic review that aimed to discuss the concepts of autonomy, consent and vulnerability of clinical research participants by the qualitative approach. It also discussed autonomy versus paternalism, vulnerability and the double standard, and the practice of moral imperialism in peripheral countries. Reflections are offered on the points mentioned above in the light of Latin American Bioethics. Finally, the restructuring of legislation and of Research Ethics Committees represents a new perspective. Keywords: Personal autonomy. Informed consent. Health vulnerability. Research subjects. Research-Humans. ResumoAutonomia, consentimento e vulnerabilidade do participante de pesquisa clínica Esta revisão bibliográfica tem como objetivo discutir os conceitos de autonomia, consentimento e vulnerabilidade do participante de pesquisa clínica por meio de abordagem qualitativa. Discute-se ainda a relação da autonomia versus paternalismo; a vulnerabilidade e o double standard; e a prática do imperialismo moral em países periféricos. Ponderam-se os pontos mencionados sob o prisma da bioética latino-americana. Por fim, é apontada como nova perspectiva a reestruturação da legislação e dos comitês de ética em pesquisa. Palavras-chave: Autonomia pessoal. Consentimento livre e esclarecido. Vulnerabilidade em saúde. Sujeitos da pesquisa. Pesquisa-humanos. Resumen Autonomía, consentimiento y vulnerabilidad del participante de investigación clínicaEste estudio de revisión bibliográfica tiene como objetivo discutir los conceptos de autonomía, consentimiento y vulnerabilidad del participante de investigación clínica, por medio de un enfoque cualitativo. Se discute también al respecto de la autonomía versus el paternalismo, la vulnerabilidad y el double standard, y la práctica del imperialismo moral en países periféricos. Se hace una reflexión sobre los puntos mencionados bajo el prisma de la bioética latinoamericana. Finalmente, se señalan como nuevas perspectivas la reestructuración de la legislación y de los comités de ética en investigación. Palabras clave: Autonomía personal. Consentimiento informado. Vulnerabilidad en salud. Sujetos de investigación. Investigación-Humanos. Declara não haver conflito de interesse.

show abstract

Pesquisa clínica como estratégia de desenvolvimento em saúde

Cited by 27 publications

References 18 publications

Perfil das dissertações e teses brasileiras acerca do trauma: uma pesquisa documental

Perfil das dissertações e teses brasileiras acerca do trauma: uma pesquisa documental

Sponsored multicentric clinical research conducted in Brazil in the respiratory area - losses and gains

Autonomia, consentimento e vulnerabilidade do participante de pesquisa clínica

Contact Info

Product

Resources

About