Influência de fatores maternos e neonatais no desenvolvimento da displasia broncopulmonar

Lima, Marcela Raquel de Oliveira; Andrade, Maria do Amparo; Araújo, Ana Paula G. de; Figueroa, José Natal; Andrade, Lívia Barboza de

doi:10.1590/s0104-42302011000400012

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…For the other maternal variables analyzed (maternal age, maternal schooling, receipt of prenatal care, infection and antenatal steroid use), no significant differences were found between the groups. Cunha et al ( 28 ) and Lima et al ( 29 ) also did not observe any influences of these variables on the incidence of BPD. However, some of these factors may induce premature birth and increase the risk of delayed NPMD.…”

Section: Discussionmentioning

confidence: 86%

“…Thus, proper prenatal care is extremely important. ( 29 ) In the logistic regression analysis, the antenatal use of steroids was shown to be a protective factor for changes in NPMD, likely because it accelerates fetal pulmonary maturation when there is a risk of premature delivery, thus reducing the incidence of respiratory diseases and dependence on ventilatory support.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of the neuropsychomotor development in the first year of life of premature infants with and without bronchopulmonary dysplasia

Silva

Araújo

Azevedo

2018

Revista Brasileira De Terapia Intensiva

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ObjectiveTo compare the neuropsychomotor development in the first year of life of premature infants with and without bronchopulmonary dysplasia.MethodsA cross-sectional retrospective study was conducted between January 1, 2014, and December 30, 2015, with premature infants weighing < 1,500g at birth and diagnosed with bronchopulmonary dysplasia at the corrected ages of 6 and 9 months, assessed using the DENVER II Developmental Screening Test. Quantitative variables were described as the means, medians and standard deviations. Variables with normal distribution were tested using Student's t test; otherwise, the Mann-Whitney test was used, considering significance at p-value < 0.05. Qualitative variables were expressed as frequencies and percentages. Logistic regression was used with odds ratio analysis to evaluate the effects of other variables as risk factors for changes in neuropsychomotor development.ResultsInfants with bronchopulmonary dysplasia showed greater developmental delay compared with those without bronchopulmonary dysplasia (p-value = 0.001). The factors associated with a higher incidence of changes in neuropsychomotor development, in addition to bronchopulmonary dysplasia, were antenatal steroid, gender, birth weight, 5-minute Apgar score, Score for Neonatal Acute Physiology-Perinatal Extension, duration of oxygen therapy, duration of mechanical ventilation and length of hospital stay. Other variables may also have influenced the result, such as drug use by mothers of infants with bronchopulmonary dysplasia.ConclusionBronchopulmonary dysplasia associated with other pre- and postnatal factors may be considered a risk factor for delayed neuropsychomotor development in the first year of life in premature infants born weighing less than 1,500g.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Assessment of the neuropsychomotor development in the first year of life of premature infants with and without bronchopulmonary dysplasia

Silva

Araújo

Azevedo

2018

Revista Brasileira De Terapia Intensiva

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“…Unavailable (5) Experimental study (4) Topics not reported (4) Other type of study (6) Other type of disease (9) Articles included in systematic Compared to CG, BPDG had lower FRC up to 10.5 months of PCA; BPDG showed decreased corrected and absolute expiratory flows compared to CG. The linear regression slope of the VMA-XFRC x length was lower in BPDG, indicating low AWs growth.…”

Section: Abstracts Screened (N = 61)mentioning

confidence: 99%

“…Neonatal chronic lung disease, also known as bronchopulmonary dysplasia (BPD), is defined as the need for respiratory support with oxygen and/or mechanical ventilation in the first 28 days of life [1][2][3][4] . Children who developed the disease in the postnatal period may show abnormalities in pulmonary function 5 .…”

Section: Introductionmentioning

confidence: 99%

Impact of bronchopulmonary dysplasia on pulmonary function during childhood: a systematic review

Scalco¹,

Coelho²,

Mucha³

et al. 2017

J. Hum. Growth Dev.

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Efficacy and safety of surfactant replacement therapy for preterm neonates with respiratory distress syndrome in low- and middle-income countries: a systematic review

et al. 2016

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Surfactant replacement therapy (SRT) has been shown to reduce mortality and air leaks in preterm neonates from high-income countries (HICs). The safety and efficacy of SRT in low- and middle- income countries (LMICs) have not been systematically evaluated. The major objectives of this review were to assess the (1) efficacy and safety, and (2) feasibility and cost effectiveness of SRT in LMIC settings. We searched the following databases—MEDLINE, CENTRAL, CINAHL, EMBASE and WHOLIS using the search terms 'surfactant' OR 'pulmonary surfactant'. Both experimental and observational studies that enrolled preterm neonates with or at-risk of respiratory distress syndrome (RDS) and required surfactant (animal-derived or synthetic) were included. A total of 38 relevant studies were found; almost all were from level-3 neonatal units. Pooled analysis of two randomized controlled trials (RCTs) and 22 observational studies showed a significant reduction in mortality at the last available time point in neonates who received SRT (relative risk (RR) 0.67; 95% confidence interval (CI) 0.57 to 0.79). There was also a significant reduction in the risk of air leaks (five studies; RR 0.51; 0.29 to 0.90). One RCT and twelve observational studies reported the risk of bronchopulmonary dysplasia (BPD) with contrasting results; while the RCT and most before-after/cohort studies showed a significant reduction or no effect, the majority of the case-control studies demonstrated significantly higher odds of receiving SRT in neonates who developed BPD. Two studies—one RCT and one observational—found no difference in the proportion of neonates developing pulmonary hemorrhage, while another observational study reported a higher incidence in those receiving SRT. The failure rate of the intubate-surfactant-extubate (InSurE) technique requiring mechanical ventilation or referral varied from 34 to 45% in four case-series. No study reported on the cost effectiveness of SRT. Available evidence suggests that SRT is effective, safe and feasible in level-3 neonatal units and has the potential to reduce neonatal mortality and air leaks in low-resource settings as well. However, there is a need to generate more evidence on the cost effectiveness of SRT and its effect on BPD in LMIC settings.

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Influência de fatores maternos e neonatais no desenvolvimento da displasia broncopulmonar

Cited by 5 publications

References 28 publications

Assessment of the neuropsychomotor development in the first year of life of premature infants with and without bronchopulmonary dysplasia

Assessment of the neuropsychomotor development in the first year of life of premature infants with and without bronchopulmonary dysplasia

Impact of bronchopulmonary dysplasia on pulmonary function during childhood: a systematic review

Efficacy and safety of surfactant replacement therapy for preterm neonates with respiratory distress syndrome in low- and middle-income countries: a systematic review

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