Human immunodeficiency virus (HIV) infection has increased considerably among middle-aged women. In this work we reviewed recent studies aimed at identifying possible factors related to HIV infection in climacteric women. Several associated factors are addressed, such as: climacteric symptoms, partner's change in sexual behavior in face of new drugs, negotiation over the use of preservatives in sexual intercourse, risk behavior for HIV, global self-esteem and sexual self-esteem, history of sexual abuse, drug use, stereotypes of sex life in maturity, use of antiretroviral therapy and approach to sexual function.