Avaliação da influência da nulidade dos genótipos GSTT1 e GSTM1 na carcinogênese em cabeça e pescoço

Goloni-Bertollo, Eny Maria; Biselli, Joice Matos; Correa, Lea Carolina de Lima; Maníglia, José Victor; Rossit, Andréa Regina Baptista; Ruiz, Mariana Torreglosa; Pavarino, Érika Cristina

doi:10.1590/s0104-42302006000500028

Cited by 11 publications

(7 citation statements)

References 26 publications

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“…[38][39][40][41] In a multivariate logistic analysis, we have evidenced that the GSTT1/GSTM1*0 ([ ]/ [-]) combined genotype provides a greater susceptibility for the development of spinocellular carcinoma of head and neck, similar results to those found by other authors. 7,23,42,43 Various studies could not correlate the null GSTT1 genotype with the head and neck cancer, 26,27,43 which was a result found in our study. Similarly, there was no association between this type of neoplasia and the null combined genotypes null GSTT1 and null GSTM1, as observed by Singh et al 7 On the other hand, a Chinese study has shown a correlation between the double null genotype GSTT1 and GSTM1 with nasopharynx cancer among men.…”

Section: Discussioncontrasting

confidence: 72%

“…Studies relating these polymorphisms of deletion with the occurrence of head and neck carcinoma diverge between themselves: some demonstrate the association of these neoplasias with the null genotype of GSTM1, 7,21,[23][24][25] while others do not. [26][27][28][29][30] The same occurs with the null genotype of GSTT1, showing an association with the disease 7,23,25 or not. 26,27,[30][31][32] This way, the development of head and neck cancer is the result of the interaction between environmental factors and genetic heritage.…”

Section: Original Article Introductionmentioning

confidence: 99%

“…[26][27][28][29][30] The same occurs with the null genotype of GSTT1, showing an association with the disease 7,23,25 or not. 26,27,[30][31][32] This way, the development of head and neck cancer is the result of the interaction between environmental factors and genetic heritage. 24,33 Therefore, the objectives of this work were to establish the clinical, sociodemographic profile and identify risk factors (smoking and alcohol drinking) of head and neck cancer patients.…”

Section: Original Article Introductionmentioning

confidence: 99%

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Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Leme¹,

Raposo²,

Ruiz³

et al. 2010

Rev. Assoc. Med. Bras.

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Objective. To establish the clinical and demographic profile and identify risk factors among patients with head and neck cancer, relating them to the polymorphism of GSTT1 and GSTM1. MethOds. One hundred patients with head and neck cancer and 100 control group individuals without history of neoplasm were analyzed. The molecular analysis was made by multiplex polymerase chain reaction. For statistical analysis, data were tabulated and compared by the Fisher's exact test, the Chi-square test and multiple logistic regression were also used.Results. There was prevalence of smokers (OR = 5.32, CI 95% CI = 2.04-13.86 p = 0.0006), alcohol drinkers (OR = 5.04, CI 95% = 2.19-11.59 p = 0.0001) in head and neck cancer patients. The GSTT1 null genotype was found in 47% of the patient and 41% of the control group (OR = 0.67; CI 95%= 0.34-1.35; p = 0.2648). Likewise, the GSTM1 null genotype was found in 66% of the patient and 75% of the control group (OR = 2.25; CI 95%= 1.05 -4.84; p = 0.0368). The combined GSTT1 and GSTM1 gene null genotype shown association between GSTM1*0/GSTT1 and occurrence of head and neck carcinoma (OR = 7.64; CI 95%= 1.72-34.04; p = 0.0076). Analysis of clinical-pathological features showed association between GSTT1 null genotype and larynx, the inverse relation between this genotype and pharynx. cOnclusiOn. In our study it was possible to establish an association between the nullity of GSTM1 genotype and that of combined GSTT1/GSTM1*O ([]/ [-] genotypes and head and neck cancer. gstM1 and gstt1 genes analysis in head and neck canceR patients cássia veRidiana dOuRadO leMe 1 , luis séRgiO RapOsO 2 , MaRiangela tORReglOsa Ruiz 3 , jOice MatOs biselli 4 , ana lívia silva galbiatti 5 , jOsé victOR Maniglia 6 , éRika cRistina pavaRinO-beRtelli 7 , eny MaRia gOlOni-beRtOllO 8*

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Section: Discussioncontrasting

confidence: 72%

Section: Original Article Introductionmentioning

confidence: 99%

Section: Original Article Introductionmentioning

confidence: 99%

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Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Leme¹,

Raposo²,

Ruiz³

et al. 2010

Rev. Assoc. Med. Bras.

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“…Many previous studies have revealed that polymorphisms of GSTM1 and GSTT1 are associated with cancer [22,24,50,51], but few have been conducted in CF. Fifty-three children with CF were studied by Hull and Thomson [26], of which 26 with the GSTM1 null allele had a significantly lower Shwachman-Kulczycki score.…”

Section: Resultsmentioning

confidence: 99%

Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

et al. 2014

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BackgroundCystic fibrosis (CF) clinically manifests with various levels of severity, which are thought to be modulated by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), modifier genes, and the environment. This study verified whether polymorphisms in modifier genes associated with glutathione (GSH) metabolism influence CF severity.MethodsA cross-sectional study of 180 CF patients was carried out from 2011 to 2012. We analyzed CFTR mutations, polymorphisms (GSTM1 and GSTT1 deletions, GSTP1 + 313A > G, GCLC-129C > T, and GCLC-3506A > G) in modifier genes and CF clinical severity as assessed by 28 clinical and laboratory variables.ResultsSignificant associations were found between modifier gene polymorphisms and particular phenotypes or genotype changes. These included GCLC-129C > T with a higher frequency of the Pseudomonas aeruginosa mucoid to CC genotype (p = 0.044), and GCLC-3506A > G with a higher frequency of the no-mucoid P. aeruginosa (NMPA) to AA genotype (p = 0.012). The GSTT1 deletion was associated with a higher frequency of the NMPA to homozygous deletion (p = 0.008), GSTP1 + 313A > G with a minor risk of osteoporosis (p = 0.036), and patient age ≤ 154 months (p = 0.044) with the AA genotype. The Bhalla score was associated with GCLC-3506A > G (p = 0.044) and GSTM1/GSTT1 deletion polymorphisms (p = 0.02), while transcutaneous hemoglobin oxygen saturation levels were associated with GSTT1 deletions (p = 0.048).ConclusionCF severity is associated with polymorphisms in GSH pathways and CFTR mutations.

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“…De 27 estudos examinados para avaliar o risco de CECB associado ao genótipo nulo GSTT1, em 21 deles foram relatadas OR de 1,17 (Hashibe et al, 2003). Em publicações posteriores, com pacientes com câncer em outros sítios anatômicos da cabeça e pescoço, que não a boca, alguns autores demonstraram associação positiva entre o câncer ou lesões pré malognas (Drummond et al, 2005;Barroso-Duarte et al, 2006), enquanto outros verificaram resultados semelhantes aos nossos, não encontrando qualquer associação entre o câncer de boca e a nulidade do genótipo GSTT1 (Gaudet et al, 2004;Sikdar et al, 2004;Xie et al, 2004;Gattás et al, 2006;Goloni-Bertollo et al, 2006, Hatagima et al, 2008. Apenas dois estudos demonstraram efeito protetor de GSTT1 nulo e o desenvolvimento de CECB (Evans et al, 2004;Anantharaman et al, 2007).…”

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Poliformismos genéticos no câncer de cabeça e pescoço: análise de risco e evolução clínica

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Avaliação da influência da nulidade dos genótipos GSTT1 e GSTM1 na carcinogênese em cabeça e pescoço

Cited by 11 publications

References 26 publications

Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

Poliformismos genéticos no câncer de cabeça e pescoço: análise de risco e evolução clínica

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