IgA, IgE e subclasses de IgG anti-Candida albicans no soro e lavado vaginal de pacientes com candidíase vulvovaginal

Carvalho, Ricardo José Victal de; Cunha, Cristiane Martins; Silva, Deise Aparecida de Oliveira; Sopelete, Mônica Camargo; Urzedo, Jane Eire; Moreira, Tomaz Aquino; Moraes, Paula de Souza Abreu; Taketomi, Ernesto Akio

doi:10.1590/s0104-42302003000400037

Cited by 18 publications

(4 citation statements)

References 11 publications

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“…On characterizing anti- Candida IgA, IgE, IgG, and subclass (IgG1, IgG4) antibody levels in serum and vaginal washes from women with or without vulvovaginal candidiasis, another study demonstrated significantly higher levels of IgA in vaginal washes and lower in serum, present in patients. Additionally, similar levels of serum anti- Candida IgA and IgG antibodies were observed in women with or without a history of Candida vaginitis [ 98 ]. A study by Bernardis et al reported that the anti- Candida human domain antibodies inhibited attachment of fungus to the vaginal epithelium, which protected rats from experimental vaginitis [ 99 ].…”

Section: Introductionmentioning

confidence: 82%

The Role of B-Cells and Antibodies against Candida Vaccine Antigens in Invasive Candidiasis

2021

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Systemic candidiasis is an invasive fungal infection caused by members of the genus Candida. The recent emergence of antifungal drug resistance and increased incidences of infections caused by non-albicans Candida species merit the need for developing immune therapies against Candida infections. Although the role of cellular immune responses in anti-Candida immunity is well established, less is known about the role of humoral immunity against systemic candidiasis. This review summarizes currently available information on humoral immune responses induced by several promising Candida vaccine candidates, which have been identified in the past few decades. The protective antibody and B-cell responses generated by polysaccharide antigens such as mannan, β-glucan, and laminarin, as well as protein antigens like agglutinin-like sequence gene (Als3), secreted aspartyl proteinase (Sap2), heat shock protein (Hsp90), hyphally-regulated protein (Hyr1), hyphal wall protein (Hwp1), enolase (Eno), phospholipase (PLB), pyruvate kinase (Pk), fructose bisphosphate aldolase (Fba1), superoxide dismutase gene (Sod5) and malate dehydrogenase (Mdh1), are outlined. As per studies reviewed, antibodies induced in response to leading Candida vaccine candidates contribute to protection against systemic candidiasis by utilizing a variety of mechanisms such as opsonization, complement fixation, neutralization, biofilm inhibition, direct candidacidal activity, etc. The contributions of B-cells in controlling fungal infections are also discussed. Promising results using anti-Candida monoclonal antibodies for passive antibody therapy reinforces the need for developing antibody-based therapeutics including anti-idiotypic antibodies, single-chain variable fragments, peptide mimotopes, and antibody-derived peptides. Future research involving combinatorial immunotherapies using humanized monoclonal antibodies along with antifungal drugs/cytokines may prove beneficial for treating invasive fungal infections.

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Section: Introductionmentioning

confidence: 82%

The Role of B-Cells and Antibodies against Candida Vaccine Antigens in Invasive Candidiasis

2021

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“…The protein composition of cervicovaginal fluids has already been analysed by different methods including gel electrophoresis, Western blot [14], immunodiffusion [6] and ELISA [13]. This application of microfluid chips is a new opportunity that has many advantages.…”

Section: Discussionmentioning

confidence: 99%

“…HIV [4], HSV, and Candida [10][11][12][13]) or changes in the composition of the vaginal normal bacterial flora (bacterial vaginosis) [14,15] may also cause changes in the concentration of IgA antibodies in the cervicovaginal fluid.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of protein composition and detection of IgA in cervicovaginal fluid by microchip technology

Werling

Kocsis

Dean

et al. 2008

Journal of Chromatography B

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“…Apesar disso, evidências recentes demonstram que anticorpos com especificidades definidas mostram diferentes graus de proteção (29,41) . Carvalho et al (6) demonstraram resposta acentuada de IgA, IgG1 e IgG4 anti-C. albicans no lavado vaginal de mulheres sintomáticas com cultura positiva, sugerindo importante papel desses anticorpos na resposta imune local estimulada pela presença do fungo. O mecanismo exato pelo qual esses anticorpos protegem contra infecções por Candida é desconhecido, mas parece incluir inibição da adesão ou formação do tubo germinativo, opsonização, neutralização de enzimas relacionadas com a virulência e atividade fungicida direta (43) .…”

Section: Fatores Predisponentes Do Hospedeirounclassified

Candidíase vulvovaginal: fatores predisponentes do hospedeiro e virulência das leveduras

Álvares¹,

Svidzinski²,

Consolaro³

2007

J. Bras. Patol. Med. Lab.

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; Márcia Edilaine Lopes Consolaro 3Introdução: Leveduras do gênero Candida são patógenos oportunistas freqüentemente isolados das superfícies mucosas de indivíduos normais, mas podem levar ao desenvolvimento de infecções denominadas candidíases, que variam desde lesões superficiais até infecções disseminadas. Objetivos: Ampliar os conhecimentos sobre candidíase vulvovaginal (CVV: infecção de vulva e vagina, causada por leveduras comensais que habitam a mucosa vaginal) e candidíase vulvovaginal recorrente (CVVR: ocorrência de quatro ou mais episódios de CVV no período de 12 meses), bem como caracterizar e abordar o ponto de vista das influências do hospedeiro e dos fatores de virulência dos agentes causais da infecção, principalmente C. albicans, visando identificar a sua importância nessa patologia. Tanto fatores predisponentes locais como sistêmicos do hospedeiro podem contribuir para a invasão por Candida sp. Sua intensa multiplicação no canal vaginal é favorecida por uma série de fatores predisponentes abordados nesta revisão. Também tem sido postulado que existem diferenças na patogenicidade de isolados de Candida sp., não sendo o fungo apenas um participante passivo no processo infeccioso; com isso vários fatores de virulência têm sido propostos e são descritos. Discussão e conclusões: Este artigo de revisão bibliográfica buscou atualizar os profissionais da área da saúde em relação a CVV, CVVR, aspectos predisponentes do hospedeiro e virulência dos agentes causais, que são pouco conhecidos. Assim, a atualização e o conhecimento de conceitos básicos e clínicos relacionados com essa patologia são muito importantes para auxiliar o seu manejo pelos profissionais da área. abstract resumo Introduction: Vulvovaginal candidiasis (VVC) is a vulva and vagina infection caused by comensal yeasts that inhabit the vaginal mucosa and eventually become patogenic, depending on host conditions. Eighty percentto 90% of the infections are due to C. albicans, and 10% to 20% to other species called non-C. albicans (C. tropicalis, C. glabrata, C. krusei, C. parapsilosis, C. pseudotropicalis, C. lusitaniae

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IgA, IgE e subclasses de IgG anti-Candida albicans no soro e lavado vaginal de pacientes com candidíase vulvovaginal

Abstract: RESUMO -OBJETIVO. Determinar níveis de anticorpos

Cited by 18 publications

References 11 publications

The Role of B-Cells and Antibodies against Candida Vaccine Antigens in Invasive Candidiasis

The Role of B-Cells and Antibodies against Candida Vaccine Antigens in Invasive Candidiasis

Characterisation of protein composition and detection of IgA in cervicovaginal fluid by microchip technology

Candidíase vulvovaginal: fatores predisponentes do hospedeiro e virulência das leveduras

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