Densidade microvascular no carcinoma de língua

Amar, Ali; Giovanini, Alan F.; Rosa, Marilene Paladino; Yamassaki, Hitomi O.; Carvalho, Marcos Brasilino de; Rapoport, Abrão

doi:10.1590/s0104-42302002000300031

Cited by 9 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the non-parametric tests failed to detect any correlation between MVD and tumour differentiation or nodal metastasis. These results are in agreement with Amar et al [46], who failed to demonstrate any association between MVD and patient prognosis or histological features in SCC of the tongue. A study of 33 cases of oral SCC revealed higher MVD with increasing tumour and node stages but not with survival [7].…”

Section: Discussionsupporting

confidence: 93%

Significance of Neo-Angiogenesis and Immuno-Surveillance Cells in Squamous Cell Carcinoma of the Tongue

Alkhabuli

2007

Libyan J Med

View full text Add to dashboard Cite

BackgroundNeo-angiogenesis is an essential process in physiological and pathological conditions. However, it is a complex process. Several studies demonstrated that intra-tumoural microvessel number is a significant predictor of metastasis and clinical outcome in many tumours, including oral malignancies. The immuno-surveillance cells, mast cells and eosinophils are implicated in the biological behaviour of tumours. Nevertheless, their function in tissues is uncertain. Mast cells are involved in homeostatic regulation of blood vessels as well as host defence. In some malignancies, high mast cell density has been found to correlate with favourable prognosis. However, others reported unfavourable associations. Tumour associated tissue eosinophilia is a well-known phenomena. It has been associated with good and poor prognosis. However, the role of eosinophils in tumours remains controversial. Therefore, this study was designed to investigate the prognostic value of microvessel, mast cell and eosinophil densities in the context of clinico-pathological parameters and survival in squamous cell carcinoma of the tongue.Materials and MethodsAnti-CD105 and anti-tryptase monoclonal antibodies were utilized to highlight and count microvessels and mast cells respectively in 81 cases of tongue squamous cell carcinoma. Eosinophils were demonstrated using carbol chromotrope histochemical stain. The densities were counted per mm2 and correlated with patients’ outcome and other clinico-pathological parameters using non-parametric tests and student's t-test. Clinically, the cases were divided into 4 main groups depending on survival time, lymph-node or distant metastasis.ResultsThe 5 year survival was significantly lower in patients with a low mast cell density than those with a high density (p=0.006, Kruskal-Wallis test). The survival group-A demonstrated significantly higher mast cell and microvessel numbers than group-D (p=0.007, student's t-test) respectively. Patients with well- differentiated squamous cell carcinoma had significantly higher numbers of mast cells when compared to patients with poorly differentiated squamous cell carcinoma (p<0.05, student's t-test). The lymph node involvement correlation between the survival group-A and survival group-D was also significant (p=0.001, Mann-Whitney U test).ConclusionData from this study indicates that accumulating mast cells in tumours play a part in inhibiting tumour progression and is potentially angiogenic in tumours.

show abstract

Section: Discussionsupporting

confidence: 93%

Significance of Neo-Angiogenesis and Immuno-Surveillance Cells in Squamous Cell Carcinoma of the Tongue

Alkhabuli

2007

Libyan J Med

View full text Add to dashboard Cite

show abstract

“…in 1991, Weidner et al were the first to report on the prognostic value of measurements of angiogenesis using a model of primary breast tumors (4). many investigators have supported the notion of an inverse correlation between microvascular density (mVd) and prognosis (5-7), while others have refuted this (8). mVd has also been shown to be a prognostic indicator of postoperative survival among patients with astrocytomas (3,9,10).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI

Cavalcante

Almeida²,

Clara³

et al. 2010

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. microvascular density (mVd) may be an additional prognostic marker for astrocytomas, but the heterogeneity of these tumors limits its use. thus, imaging examinations such as SpEct-miBi (2-methoxyisobutyl isonitrile) may take on an indirect role in astrocytoma evaluation. the aim of this study was to evaluate mVd in astrocytomas using immunohistochemistry with anti-cd34 monoclonal antibodies. the relationship between the immunohistochemical data and the parameters obtained from SpEct-miBi was evaluated. this cross-sectional study evaluated 48 patients with brain tumors including low-grade astrocytomas (lGas), anaplastic astrocytomas (aas) and glioblastoma multiformes (GBms). patients had been admitted to the hospital de câncer de Barretos -Fundação pio xii, and underwent brain SpEctmiBi prior to any treatment. mVd was determined under an optical microscope by counting microvessels on slides from each case. SpEct-miBi images were analyzed visually and semiquantitatively. GBms, aas and lGas represented 50, 16.7 and 33.3% of the total sample, respectively. there were 13 normal and 35 abnormal SpEct-miBi images. Significant differences in MVD were found between AA and lGa cases (p=0.040), but not between normal and abnormal SpEct-miBi. the mean counts from SpEct-miBi were not correlated with mVd. among the GBm cases, there were no significant findings, except for an increased likelihood of abnormal histological test results. mVd was related to histological grade (in aa and lGa cases) but was not correlated with SpEct-miBi.

show abstract

“…An inverse relation was reported between microvascular density in the primary tumor and its respective metastases, suggesting that increased angiogenesis in a specific site might inhibite angiogenesis at a distance 11,12 . The hypothesis that metastases from occult primary tumors could inhibit the growth of the primary tumor could be supported by increased microvascular density, however we found great variability in our study.…”

Section: Resultsmentioning

confidence: 99%

Reatividade linfonodal e densidade microvascular nas metástases cervicais de carcinoma epidermóide com tumor primário oculto

Amar

Giovanini

Rosas

et al. 2006

Rev. Bras. Otorrinolaringol.

Self Cite

View full text Add to dashboard Cite

INTRODUÇÃO: A neoangiogênese e a resposta imunológica são mecanismos importantes no desenvolvimento das metástases. OBJETIVO: Avaliar a reatividade linfonodal e a densidade microvascular nas metástases cervicais de carcinoma epidermóide com tumor primário oculto, considerando a sua relação com outras variáveis histológicas e clínicas. TIPO DE ESTUDO: Série de casos, retrospectiva. CASUÍSTICA E MÉTODO: 19 pacientes submetidos a esvaziamento cervical entre 1983 e 2000. Os linfonodos foram reavaliados quanto ao tipo de reatividade, considerando a área cortical e paracortical. Nas metástases foi avaliado o grau de diferenciação, desmoplasia, necrose, e densidade microvascular (CD34). Foi estabelecida a relação entre as diferentes variáveis histológicas e clínicas, incluindo o estadiamento e a evolução dos pacientes. RESULTADOS: A densidade microvascular apresentou mediana de 91 vasos/mm2, variando de 28 a 145. A reatividade paracortical foi mais freqüente nos pacientes com menos de 55 anos (90% x 44%, p= 0,05). A sobrevida livre de doença foi de 52% em 3 anos, sendo similar entre os pacientes com maior ou menor densidade microvascular tumoral. CONCLUSÕES: A densidade microvascular nas metástases de tumor primário oculto apresenta grande variação individual. Não foi possível estabelecer relação entre a densidade microvascular e as variáveis clínicas e histológicas estudadas.

show abstract

Densidade microvascular no carcinoma de língua

Cited by 9 publications

References 11 publications

Significance of Neo-Angiogenesis and Immuno-Surveillance Cells in Squamous Cell Carcinoma of the Tongue

Significance of Neo-Angiogenesis and Immuno-Surveillance Cells in Squamous Cell Carcinoma of the Tongue

Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI

Reatividade linfonodal e densidade microvascular nas metástases cervicais de carcinoma epidermóide com tumor primário oculto

Contact Info

Product

Resources

About