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Cited by 47 publications
(16 citation statements)
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References 44 publications
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“…Nitric oxide (NO) is a small simple molecule, intercellular messenger in higher mammals, an important neurotransmitter, with potentiating capacity, endocrine, autocrine and paracrine actions (Flora-Filho and Zilberstein, 2000). Nitric oxide acts as a possible vascular neuromodulator in the regulation of specific secretory processes in the upper aerodigestive tract (Ellies et al, 2006a).…”
Section: Discussionmentioning
confidence: 99%
“…Nitric oxide (NO) is a small simple molecule, intercellular messenger in higher mammals, an important neurotransmitter, with potentiating capacity, endocrine, autocrine and paracrine actions (Flora-Filho and Zilberstein, 2000). Nitric oxide acts as a possible vascular neuromodulator in the regulation of specific secretory processes in the upper aerodigestive tract (Ellies et al, 2006a).…”
Section: Discussionmentioning
confidence: 99%
“…Given its short half‐life, NO was quantified indirectly based on its nitrite and nitrate (NO 3 −/NO 2 −) metabolite production (Flora‐Filho and Zilberstein, ). For this purpose, droplets of medium from D8 of culture were stored at −20°C for later analysis using the Griess colorimetric method (Ricart‐Jane et al, ).…”
Section: Methodsmentioning
confidence: 99%
“…Prolonged oxidative stress observed in non-treated OSAS reduces the activity of the endothelial nitric oxide synthase (NOS), an enzyme responsible for assisting several cells to synthesize NO, an important neurotransmitter acting in the regulation of inflammation and autoimmune mechanisms [17,27]. Therefore, the reduction of its production can result in endothelial dysfunction and thereby predispose to vascular morbidities in OSAS [27].…”
Section: Hypoxia Oxidative Stress and Inflammatory Responsementioning
confidence: 99%
“…Therefore, the reduction of its production can result in endothelial dysfunction and thereby predispose to vascular morbidities in OSAS [27].…”
Section: Hypoxia Oxidative Stress and Inflammatory Responsementioning
confidence: 99%