Pesquisa de micronúcleos na mucosa esofágica e sua relação com fatores de risco ao câncer de esôfago

Dietz, Judite; Diehl, Ada S.; Prolla, João Carlos; Furtado, Claudia D.; Furtado, Amanda da Silva

doi:10.1590/s0104-42302000000300004

Cited by 15 publications

(9 citation statements)

References 20 publications

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“…Quantification of micronucleated cells has been employed in oral cytopathology for biomonitoring of populations exposed to carcinogens and/or mutagens, including tobacco and alcohol, and also for detecting mutagenic and/or carcinogenic substances. [5][6][7]10,[13][14][15][16][17] In the present study, the mean numbers of micronucleated cells in patients exposed to carcinogens were not different in 3 anatomic sites. However, an increasing trend toward cytogenetic damage was observed in association with exposure to carcinogens.…”

Section: Discussionmentioning

confidence: 71%

Assessment of Micronucleus Frequency in Normal Oral Mucosa of Patients Exposed to Carcinogens

et al. 2005

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Section: Discussionmentioning

confidence: 71%

Assessment of Micronucleus Frequency in Normal Oral Mucosa of Patients Exposed to Carcinogens

et al. 2005

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“…Given that MN can only be detected in cells that underwent division (Dietz et al, 2000), and that the stressful conditions can lead to an atypical physiological condition that can indirectly alter the cell cycle (Cohen, Marshall, Cheng, Agarwal, & Wei, 2000;Setlow, 1978), the presented scenario might indicate that such events can represent a cause/effect relationship. The physiological conditions generated by prolonged, continual stress might act directly and/or indirectly at the genetic level, leading not only to genomic damaging, but also to the deregulation of the cell cycle, favoring the occurrence of MN and possibly cancer predisposition.…”

Section: Discussionmentioning

confidence: 99%

“…MN are caused, either by being induced or spontaneously, from chromosomal fragments or entire chromosomes that are not incorporated within the nucleus of the daughter cell during mitosis. Such elements are enclosed within secondary nuclei known as MN, from which they obtained their name (Dietz, Diehl, Prolla, Furtado, & Furtado, 2000).…”

Section: Introductionmentioning

confidence: 99%

On the stress by photoperiod, temperature and noise as possible causes of genomic damaging in an animal model

Adam¹,

Torres²,

Franci³

et al. 2010

Stress and Health

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Stress is a defense mechanism of an organism and is directly related to homeostasis, which is the equilibrium state of the multitude of organism systems, both among each other and with the environment. Given that stress is a major cause of cellular instability, it is directly related to its loss homeostasis. The present study assessed the changes caused by stress on the genetic material of Rattus norvegicus using micronuclei analysis. A total of 10 males were studied by being submitted to continuous stress from photoperiod, temperature and noise for 26 days. Peripheral blood samples were obtained immediately before submitting the animals to stress, as well as on the fifteenth and twenty‐sixth days afterwards. Blood smears were stained with Giemsa and the slides were analyzed using light microscopy. Approximately 3,000 polychromatic erythrocytes from each animal were observed and classified as either normal or micronucleated. The analysis indicated a frequency of 0.0012014 for the control sample, whereas samples on days 15 and 26 had frequencies of 0.0035458 and 0.0496850, respectively. A statistical analysis revealed statistically significant differences among the studied cell samples (ANOVA p < 0.00001, significance of 5%). Therefore, the presence of micronuclei in the studied samples is consistent with a cause/effect relationship. Copyright © 2010 John Wiley & Sons, Ltd.

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“…Clinical/experimental (in vivo: humans and animals). The possible genotoxic activity of mate was studied in samples drawn from the esophageal mucosa; the patients were interviewed on their habits after the endoscopy (43). The findings indicated a higher frequency of micronucleus among the tobacco smokers and mate drinkers; however, the significance of the micronucleus in tumor occurrence has still to be understood.…”

Section: Other Studiesmentioning

confidence: 99%

Cancer and yerba mate consumption: a review of possible associations

Loria

Barrios

Zanetti³

2009

Rev Panam Salud Publica

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The role of hot mate in increasing the risk of cancer of esophagus, larynx, and oral cavity seems to be supported by several epidemiological studies. The temperature could act by damaging the mucosa or accelerating metabolic reactions, including those with carcinogenic substances in tobacco and alcohol. However, there is no sound population-based case-control study on mate consumption as a risk factor for cancer. This, coupled with the range of results on mate risk, make assessing the etiological fraction difficult. More research needs to be done before a definitive statement can be made regarding cancer risk associated with any of the various forms of mate consumption. Future research should include population-based studies; collection of data on consumption of tobacco, alcohol, hot drinks, fresh fruit, and vegetables; and, a method to precisely measure volume and temperature of mate intake.

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Pesquisa de micronúcleos na mucosa esofágica e sua relação com fatores de risco ao câncer de esôfago

Abstract: A higher frequency of micronucleus in the esophageal mucous in smoking and "maté" drinkers was evidenced by this study.

Cited by 15 publications

References 20 publications

Assessment of Micronucleus Frequency in Normal Oral Mucosa of Patients Exposed to Carcinogens

Assessment of Micronucleus Frequency in Normal Oral Mucosa of Patients Exposed to Carcinogens

On the stress by photoperiod, temperature and noise as possible causes of genomic damaging in an animal model

Cancer and yerba mate consumption: a review of possible associations

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