Revisão: transportadores de água

Cheidde, Lara; Schor, Nestor

doi:10.1590/s0104-42301999000100013

Cited by 3 publications

(2 citation statements)

References 66 publications

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“…In salivary glands of rats was identified aquaporin 5 (Cheidde and Schor, 1999;Melvin et al, 2005;Catalan et al, 2009). Xu et al (2015) also verified clinically the salivary flow of animals and concluded that salivary flow is reduced depending on the dose applied, agreeing with Shan et al (2013).…”

Section: Discussionmentioning

confidence: 99%

Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

2016

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The treatment of sialorrhea is necessary for the constant risks posed by hypersalivation. A new therapeutic option comes up with the application of botulinum toxin in salivary glands. However, little is known about its mechanism of action in glandular tissue. Based on the above, this work had the objective to systematically review the literature about the action of botulinum toxin on submandibular and parotid salivary glands tissues. Electronic search was performed in databases of great relevance for this study (PubMed, SciELO, HighWire, Crossref, Scopus, Science Direct, MEDLINE, OLDMEDLINE, Serials Database, NLM Catalog, LILACS and IBECS). Inclusion and exclusion criteria for articles were established, and a total number of 14 articles were selected and used. There are few publications that clarify how the salivary gland acini behave with application of botulinum toxin. Although, the immunohistochemical findings were consistent among authors, showing weak immunoreactivity in glands treated with botulinum toxin. Histometric data are divergent, requiring more detailed studies to answer the questions about the efficacy and safety of botulinum toxin in salivary glands.Keywords: botulinum toxins, salivary glands, sialorrhea, botulinum toxin type A.Achados histológicos e imunohistoquímicos da ação da toxina botulínica em glândula salivar: revisão sistemática ResumoO tratamento da sialorreia se faz necessário pelos constantes riscos trazidos por este estado de hipersalivação. Uma nova opção terapêutica surge com a aplicação da toxina botulínica em glândulas salivares. Entretanto, pouco se sabe sobre o seu mecanismo de ação no tecido glandular. Com base no exposto, este trabalho teve o objetivo de revisar sistematicamente na literatura a ação da toxina botulínica sobre o tecido das glândulas salivares submandibular e parótida. Foi realizada uma busca eletrônica em bases de dados de grande relevância para este estudo (PubMed, SciELO, HighWire, Crossref, Scopus, Science Direct, MEDLINE, OLDMEDLINE, Serials Database, NLM Catalog, LILACS e IBECS). Foram estabelecidos critérios de inclusão e exclusão para os artigos, e um "n" de 14 trabalhos foram selecionados e utilizados. São poucas as publicações que esclarecem como os ácinos das glândulas salivares se comportam mediante aplicação da toxina botulínica. Apesar de os achados imunohistoquímicos entre os autores serem concordantes, com imunorreatividade mais fracas nas glândulas tratadas com a toxina botulínica, os dados histométricos são divergentes e há questionamentos metodológicos, necessitando de mais estudos pormenorizados para responder as questões sobre a eficácia e segurança da toxina botulínica nas glândulas salivares.Palavras-chave: toxinas botulínicas, glândulas salivares, sialorreia, toxinas botulínicas tipo A.

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Section: Discussionmentioning

confidence: 99%

Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

2016

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“…A reabsorção da maior parte dos eletrólitos e da água filtrada é uma função primária do néfron e sua regulação é essencial para a manutenção do balanço de fluidos corpóreos. O processo de reabsorção de volume envolve o movimento de água através da camada de células epiteliais de várias regiões do néfron em resposta à diferença de osmolalidade através das membranas celulares individuais e/ou dos complexos juncionais e espaços paracelulares que separam as células adjacentes (5).…”

Section: Mecanismo De Concentração E Diluição Urináriaunclassified

Efeito da carbamazepina na reabsorção de água pelo ducto coletor medular interno de ratos normais e de ratos com diabetes insípido nefrogênico induzido pelo lítio

Bragança¹

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Review Structure, function, and localization of aquaporins: their possible implications on gamete cryopreservation

Sales¹,

Lobo²,

Carvalho³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. The discovery of water channels (aquaporins, AQPs) was a landmark event for the clarification of water transport through the plasma membrane. AQPs belong to a family of intrinsic membrane proteins that act as selective channels for water and for solutes such as glycerol and urea. AQPs were found in different tissues and organs, including male and female reproductive systems. In the swine female reproductive system, the AQPs were localized in the uterus, oviduct, and ovary, as well as in the granulosa cells from primordial follicles. Knowing the involvement of AQPs with the male and female germ cells, as well as their acknowledged role in transporting water through the plasma membrane, the research of these proteins in cryopreservation processes becomes essential. Thus, this review aims to describe the structure and function of AQPs in membranes, highlighting their role 6719 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 6718-6732 (2013) Overview and role of aquaporins on gamete cryopreservation in the reproductive system (male and female). We also discuss the involvement of AQPs in cryopreservation, focusing on the effect and importance of these proteins on the rates of vitrification protocols for preantral follicles present in the ovarian tissue of domestic mammals.

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Revisão: transportadores de água

Cited by 3 publications

References 66 publications

Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

Histological and immunohistochemical findings of the action of botulinum toxin in salivary gland: systematic review

Efeito da carbamazepina na reabsorção de água pelo ducto coletor medular interno de ratos normais e de ratos com diabetes insípido nefrogênico induzido pelo lítio

Review Structure, function, and localization of aquaporins: their possible implications on gamete cryopreservation

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