Efeito da infecção hospitalar da corrente sanguínea por Staphylococcus aureus resistente à oxacilina sobre a letalidade e o tempo de hospitalização

Moreira, Marina; Medeiros, Eduardo Alexandrino Sérvolo de; Pignatari, Antônio Carlos Campos; Wey, Sérgio Barsanti; Cardo, Denise M.

doi:10.1590/s0104-42301998000400002

Cited by 20 publications

(13 citation statements)

References 58 publications

(32 reference statements)

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“…In our study, we performed an assessment of DDD in clinics where cases of infection were detected, and we were unable to demonstrate this relationship; however, the DDDs in our hospital were similar to those reported in other studies involving tertiary hospitals 18 . When this evaluation was performed in other critical care units, the use of these drugs was found to be much higher than that in North American and European ICUs, especially with respect to extended-spectrum cephalosporins and carbapenems (data not shown) 12,19 . Data not shown.…”

Section: Discussionmentioning

confidence: 93%

Active surveillance to determine the impact of methicillin resistance on mortality in patients with bacteremia and influences of the use of antibiotics on the development of MRSA infection

Porto

Santos

Filho

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 46(6):713-718, Nov-Dec, 2013http://dx.doi.org/10. ABSTRACT Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is among the most important pathogens of nosocomial infections, mainly in intensive care units (ICUs), and accounts for 40-60% of all healthcare-associated S. aureus infections. We evaluated the incidence of nosocomial infection by S. aureus, identifi ed the risk factors for MRSA infection, and evaluated the effect of resistance to methicillin on mortality in patients. Methods: We conducted MRSA surveillance at a university hospital in Brazil from January 1, 2010, to December 31, 2010, and performed a retrospective case-control matched study to evaluate the frequency of subsequent MRSA bacteremia and death among patients. We evaluated and compared the risk factors between patients with MRSA and methicillin-sensitive Staphylococcus aureus (MSSA) infection. Results: Sepsis was the most common cause of infection (17.7/1,000 patient-days), followed by surgical site (11.4/1,000 patient-days), pneumonia (4.1/1,000 patient-days), and urinary tract infection (2.4/1,000 patient-days). The signifi cant risk factors were time of hospitalization, use of central vascular catheter (CVC), urinary catheter, nasogastric tube, parenteral nutrition, tracheostomy, mechanical ventilation, and previous antibiotic administration, the latter of which was the only independent risk factor for MRSA infection. Mortality was signifi cantly higher in patients with MRSA. The number of antibiotics tested was not related to increases in the frequency of MRSA/1,000 patient-days. The incidence of mortality attributable to MRSA (bloodstream infection) BSI was 50%. Conclusions: Surveillance results showed that the use of high levels of antibiotics was directly related to the development of MRSA infection, and the mortality attributable to MRSA in patients with bacteremia was signifi cant.

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Section: Discussionmentioning

confidence: 93%

Active surveillance to determine the impact of methicillin resistance on mortality in patients with bacteremia and influences of the use of antibiotics on the development of MRSA infection

Porto

Santos

Filho

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…This bacterium can normally be found in oral cavities, provoking 34,16 gingivitis, or even meningitis, bronchitis and pneumonia . Bacteria of the Gemella fgenus were the main finding in the 38 Moreira study, when isolating ants from hospitals in Rio de Janeiro.…”

Section: Discussionmentioning

confidence: 99%

Bactérias isoladas de culicídeos (Diptera: Nematocera) hematófagos em Belém, Pará, Brasil

Alves

Gorayeb

Loureiro³

2010

Rev Pan-Amaz Saude

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“…High prevalence of MRSA in the large Brazilian public and university hospitals has been found. In our setting, 73.2% of bloodstream S. aureus hospital infections arose from MRSA [3]. ICUs are important reservoirs in the MRSA epidemiology, and they may be a source of dissemination to other areas of the hospital [3][4][5].…”

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confidence: 86%

Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit

et al. 2007

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Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in most Brazilian Hospitals, and there are few studies which show the efficacy of control measures in such situations. This study evaluated intensive care unit (ICU) patients, in two years divided in control, intervention and post-intervention group. Intervention measures: hands-on educational programs for healthcare workers; early identification of MRSA infected or colonized patients, labeled with a bed-identification tag for contact isolation; nasal carriers, patients, and healthcare professionals treated with topical mupirocin for five days. The hospital infection rates in the control period were compared to the ones in the post-intervention period. Hospital infection rates were found by means of the NNISS methodology The incidence coefficients of MRSA hospital infection (monthly average of 1,000 pts/day) in the control, intervention and post-intervention groups were respectively: 10.2, 5.1 and 2.5/1,000 pts/day (p<0.001) and MRSA-originated bloodstream infections were 3.6, 0.9 and 1.8/1,000 central venous catheter/day (p=0.281). Nasal colonization in both intervention and post-intervention periods was of 30.9% and 22.1% among the hospitalized patients, respectively 54.4% and 46.1% of whom were already MRSA-positive when admitted to the unit. In the intervention period, most of those MRSA infected patients (76.2%) were nasal carrier. Mortality rates were, respectively 26.6%; 27.3% and 21.0% (p<0.001). Nasal carriers, both patients (93.7%) and healthcare professionals (88.2%), were successfully treated with topical mupirocin. Intervention measures for the prevention and control of MRSA infections in ICUs, have been efficient in the reduction of the bloodstream and MRSA-originated hospital infections incidence, and reduced the overall mortality rate significantly.

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Efeito da infecção hospitalar da corrente sanguínea por Staphylococcus aureus resistente à oxacilina sobre a letalidade e o tempo de hospitalização

Cited by 20 publications

References 58 publications

Active surveillance to determine the impact of methicillin resistance on mortality in patients with bacteremia and influences of the use of antibiotics on the development of MRSA infection

Active surveillance to determine the impact of methicillin resistance on mortality in patients with bacteremia and influences of the use of antibiotics on the development of MRSA infection

Bactérias isoladas de culicídeos (Diptera: Nematocera) hematófagos em Belém, Pará, Brasil

Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit

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