1997
DOI: 10.1590/s0104-42301997000100014
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Abstract: Nas últimas décadas, foram realizadas inúmeras pesquisas para esclarecer o papel dos radicais livres em processos fisiopatológicos como envelhecimento, câncer, aterosclerose, inflamação, etc. Ao abrirmos um periódico, com freqüência, encontramos temas relacionados a radicais livres, que, por seu caráter multidisciplinar, têm atraído a atenção de pesquisadores de várias áreas. No entanto, os artigos desta linha de pesquisa, muitas vezes, causam desinteresse no leitor não-especializado, porque estão mergulhados … Show more

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Cited by 217 publications
(230 citation statements)
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References 43 publications
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“…Vitamin C or ascorbate is a potent hydrosoluble antioxidant in biological systems in vitro 19 because it is an electron donor that can directly neutralize ROS 20 . Depending on the dosage, however, it can also act as a pro-oxidant 19,20 , considering that ascorbate accelerates the glycation end-product formation by connecting the copper protein ascorbylated with free radicals generation by copper-protein complex 19 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Vitamin C or ascorbate is a potent hydrosoluble antioxidant in biological systems in vitro 19 because it is an electron donor that can directly neutralize ROS 20 . Depending on the dosage, however, it can also act as a pro-oxidant 19,20 , considering that ascorbate accelerates the glycation end-product formation by connecting the copper protein ascorbylated with free radicals generation by copper-protein complex 19 .…”
Section: Discussionmentioning
confidence: 99%
“…Depending on the dosage, however, it can also act as a pro-oxidant 19,20 , considering that ascorbate accelerates the glycation end-product formation by connecting the copper protein ascorbylated with free radicals generation by copper-protein complex 19 .…”
Section: Discussionmentioning
confidence: 99%
“…The plasma membrane is one of the most reached places by this biochemical reaction, which leads to changes in its structure and permeability. For this reason, there is lack of selectivity in the ion exchange, organelle content releasing, and production of cytotoxic substances such as malondialdehyde/thiobarbituric acid reactive substances (MDA/TBARS), which cause cell death (Ferreira et al, 1997). The central nervous system (CNS) substantially consists of membranes and fatty acids, which increase the vulnerability of lipid membrane components to oxidative damage and the direct action of free radicals (Vedder et al, 1999).…”
Section: Introductionmentioning
confidence: 99%
“…Desta forma, danos a esta camada lipídica tendem a diminuir a fluidez da membrana. Embora todos os componentes celulares sejam suscetíveis à ação de espécies reativas de oxigênio, a membrana é uma das mais atingidas em decorrência da peroxidação lipídica, a qual acarreta alterações na estrutura e na permeabilidade das membranas celulares, e consequente perda de seletividade na troca iônica e liberação do conteúdo de organelas com formação de produtos citotóxicos (como o malonaldeído), culminando com a morte celular 7 .…”
Section: Pesounclassified