2004
DOI: 10.1590/s0104-14282004000300013
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Abstract: Os dispositivos biorreabsorvíveis são alternativas para fixação interna das fraturas. Durante o tratamento estes dispositivos mantêm a fixação e degradam-se gradualmente não necessitando de uma cirurgia de remoção, reduzindo o custo de tratamento quando comparadas aos dispositivos metálicos. O objetivo desse trabalho foi estudar a interação polímero/tecido utilizando pinos de PLGA e PDS após implantes em coelhos Nova Zelândia. Separou-se os animais em 3 grupos os quais foram sacrificados após 3, 6 e 12 semanas… Show more

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Cited by 11 publications
(9 citation statements)
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“…Our results agree with other reports showing that a four-week interval after implantation is insufficient for osteochondral regeneration; in this period, only the initial performance of the scaffold and the occurrence of an inflammatory response can be evaluated [35][36][37][38] . In contrast, bone neoformation is readily observed 12 weeks after the implantation of PLGA and PLLA 18,35 . Fedrizzi and Duek 28 showed that PLDLA/PCL-T (90/10 composition) pins were sufficiently biocompatible for bone regeneration in tibia and this polymer combination held promising prospects for osteochondral applications.…”
Section: Resultsmentioning
confidence: 96%
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“…Our results agree with other reports showing that a four-week interval after implantation is insufficient for osteochondral regeneration; in this period, only the initial performance of the scaffold and the occurrence of an inflammatory response can be evaluated [35][36][37][38] . In contrast, bone neoformation is readily observed 12 weeks after the implantation of PLGA and PLLA 18,35 . Fedrizzi and Duek 28 showed that PLDLA/PCL-T (90/10 composition) pins were sufficiently biocompatible for bone regeneration in tibia and this polymer combination held promising prospects for osteochondral applications.…”
Section: Resultsmentioning
confidence: 96%
“…However, this reaction is of minimal importance for tissue neoformation since it disappears after the complete degradation and bioreabsorption of the polymer 18,20,21,[26][27][28][29] . Porous scaffolds can be prepared by several techniques and have a useful morphology for tissue engineering since their porosity provides physical space for cell growth and colonization.…”
Section: Resultsmentioning
confidence: 99%
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“…We have reported the synthesis and development of a number of bioreabsorbable polylactide-based polymers obtained by ring-opening polymerization of lactide and glycolide monomers [7][8][9][10] . Their potential use as biomedical devices and their biocompatibility with skin, bone, cartilage and neuronal tissue also have been explored [11][12][13][14][15] . Among the polymers synthesized by the group, we highlight the amorphous copolymer poly(L-co-D,L lactide)-PLDLA which has molecular weight range of 10 5 g/mol and glass transition temperature of 55-60 o C 8,16 .…”
Section: Introductionmentioning
confidence: 99%
“…One of the most important applications of lactic acid is in the production of biodegradable materials, such as polylactate (PLA), which is used in the production of bags, computers components (Ohara, 2003), food packaging and plastic utensils. As PLA is bioabsorbable material, it is also employed in medicine in the regeneration of tissues, sutures, repairs and implants (Sakata et al, 2004). Polymers produced with D(-) and L(+) lactic acid have properties similar to plastics produced from fossil reserves, but offer the ad-vantage of a high degree of biodegradability.…”
Section: Introductionmentioning
confidence: 99%