2010
DOI: 10.1590/s0104-12902010000600008
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Abstract: O curso clínico da infecção pelo HIV é determinado por complexas interações entre características virais e o hospedeiro. Variações no hospedeiro, a exemplo das mutações CCR5Δ32 e CCR264I, são importantes para a vulnerabilidade e progressão do HIV/aids. Atualmente, observa-se um aumento do número de casos da infecção entre os segmentos da sociedade com menor nível de escolaridade e pior condição socioeconômica. Com o objetivo de estimar a ancestralidade e verificar a sua associação com renda, escolaridade vulne… Show more

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Cited by 7 publications
(4 citation statements)
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“…As explained in the introduction section, CCR5D32 exerts its protective effect against HIV infection through two mechanisms: reduced expression of the CCR5 gene (gene-dosage effect; probably the most important mechanism) (60,63) and sequestration of CCR5 and CXCR4 from the cell surface (65,66). Many studies that evaluated CCR5D32 in the Brazilian population corroborated the protective effect of the variant on susceptibility or clinical aspects of HIV infection (e.g., [117][118][119][120], although other studies have not evidenced these effects, in some cases probably due to the small sample size (e.g., 121,122). The main results of the studies involving CCR5D32 and HIV infection in Brazil are detailed in Table 1.…”
Section: Ccr5d32 In Infectious Diseasesmentioning
confidence: 99%
“…As explained in the introduction section, CCR5D32 exerts its protective effect against HIV infection through two mechanisms: reduced expression of the CCR5 gene (gene-dosage effect; probably the most important mechanism) (60,63) and sequestration of CCR5 and CXCR4 from the cell surface (65,66). Many studies that evaluated CCR5D32 in the Brazilian population corroborated the protective effect of the variant on susceptibility or clinical aspects of HIV infection (e.g., [117][118][119][120], although other studies have not evidenced these effects, in some cases probably due to the small sample size (e.g., 121,122). The main results of the studies involving CCR5D32 and HIV infection in Brazil are detailed in Table 1.…”
Section: Ccr5d32 In Infectious Diseasesmentioning
confidence: 99%
“…5 The state of Mato Grosso (3.5 million inhabitants) also presents this characteristic with the predominant miscegenation of three ethnic groups: Africans, Amerindians and Europeans.…”
mentioning
confidence: 99%
“…[1][2][3][4][5][6][7] It is known that the vulnerability of individuals to certain diseases, as in the case of Acquired Immunodeficiency Syndrome (AIDS), is dependent on several ethnic, genetic, socioeconomic and environmental factors. These added factors drive the spread of HIV/AIDS.…”
mentioning
confidence: 99%
“…Vou botar fogo no engenho aonde o negro apanhou. O negro é gente como o outro, quer ter carinho e ter amor" (Versão Pastoral da Juventude) que contribuem para a vulnerabilidade às IST/Aids (Lopez, 2012;Riscado, Oliveira & Brito, 2010;Silva, Lima & Hamann, 2010;Lopes, 2003;Abe-Sandes et al, 2010).…”
Section: Introductionunclassified