Duration of an induced resistance of sheep to acute poisoning by Crotalaria retusa seeds

Maia, Lisanka Ângelo; Pessoa, Clarice Ricardo de Macêdo; Rodrigues, Angélica Fernandes; Colegate, Steven M.; Dantas, Antônio Flávio Medeiros; Medeiros, Rosane M.T.; Riet-Correa, Franklin

doi:10.1590/s0103-84782014000600017

Cited by 3 publications

(3 citation statements)

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“…Estes resultados não foram compatíveis ao encontrados nos nossos estudos, uma que vez que ambos os caprinos que receberam pequenas doses diárias de 2g/kg de sementes de C. spectabilis por um longo período de tempo morreram e desenvolveram sinais de intoxicação crônica. Maia et al (2014) observaram que a indução da resistência nos ovinos à intoxicação por C. retusa através da administração de pequenas doses diárias de sementes da planta tem duração limitada, entre 7 e 15 dias após suspensa a exposição a doses não tóxicas, de modo que a eficiência desta técnica seria condicionada ao contato contínuo dos animais com a planta.…”

Section: Discussionunclassified

Estudo sobre a sensibilidade dos caprinos à toxidez de crotalárias tóxicas para bovinos visando a sua utilização na profilaxia

et al. 2015

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RESUMO.-A intoxicação por plantas é sabidamente uma das principais causas de morte de bovinos adultos no Brasil. Uma vez que pouco pode ser feito no que diz respeito ao tratamento destas intoxicações, os esforços devem se concentrar na adoção de medidas profiláticas alternativas, como a utilização de uma espécie menos sensível no local de Plant poisoning is known to be one of the most important causes of death of adult cattle in Brazil. As there are not many possibilities for treatment, all efforts must focus on application of alternative prophylactic measures, among them the use of a less sensitive animal species in areas of the occurrence of certain plants. This study aimed to ascertain the sensibility of goats to crotalarias (Crotalaria spectabilis and Crotalaria juncea), so that this animal species could be used as a prophylactic measure against those plants poisonous for cattle. Single or daily doses of seeds of Crotalaria spectabilis and Crotalaria juncea were given to eight young adult goats of both sexes divided randomly in two groups of four goats, e.g. one group for each plant. None of the four goats that received seeds of Crotalaria juncea developed clinical sings of poisoning or showed changes in the biochemistry examination. Out of the four goats that received seeds of Crotalaria spectabilis, three died. One goat received a 20g/kg single dose of seeds and developed signs of acute poisoning. Postmortem and histopathological examination revealed marked centrilobular hemorrhagic necrosis. The other two goats developed chronic poisoning by the administration of 2g/kg daily doses of seeds for 35 and 150 days respectively. One goat showed severe interstitial pneumonia and mild hepatic lesions, while the other goat presented only chronic hepatic lesions. Both goats showed transient changes in the biochemistry examination. The fourth goat received a 10g/kg single dose of seeds and did not develop significant clinical or biochemical changes. The results of the present study showed that goats are not indicated to be used as a prophylactic measure against poisoning by Crotalaria spectabilis, but can be recommended as a prophylactic measure against poisoning by Crotalaria juncea.

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Section: Discussionunclassified

Estudo sobre a sensibilidade dos caprinos à toxidez de crotalárias tóxicas para bovinos visando a sua utilização na profilaxia

et al. 2015

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“…Alkaloids, saponins, tannins, steroids, flavonoids [12] Acute poisoning of sheep [14] Driving away snakes [5] Albumin [9] Anti-inflammatory, antinociceptive [9] Alkaloid monocrotaline [13,16] Genotoxic and cytotoxic on glial cells [13]…”

Section: Pharmacological Properties Previous Reports On Ethno-medicinmentioning

confidence: 99%

“…Remarkably, a general lack of knowledge on the potential toxicity of C. retusa among the herbalists and traditional healers is also evident. However, the genotoxic, neurotoxic and acute poisoning properties of C. retusa on human and animal are well documented [13,14]. According to previous pharmacological investigations, the alkaloid monocrotaline, an abundant pyrrolizidine alkaloid from C. retusa leaves and seed is responsible of the toxicity of C. retusa [13,15].…”

Section: Pharmacological Properties Previous Reports On Ethno-medicinmentioning

confidence: 99%

Ethno-medicinal Use of Crotalaria retusa L. (Fabaceae), a Pyrrolizidine Alkaloid Toxic Plant

Rouamba

Ouédraogo

Karama

et al. 2018

IJBCRR

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Objective: This current study was designed to investigate the ethno-medicinal uses of C. retusa and to learn about the knowledges of its toxicity. Methods: Questionnaires were administered to herbalists and traditional healers from Ouagadougou town in national language Mooré or Dioula. Data on the ethno-medicinal use of C. retusa, the plant part used, the modes of preparation and administration and the knowledges on its toxicity were collected for each interviewed respondents. Relative frequency of citation of each disease was calculated using Microsoft Excel software Results: C. retusa is mentioned by all the respondents to be used in the folklore system of medicine for the treat of various diseases including infectious and psychotropic diseases. Nine (09) diseases treated with C. retusa have been cited by respondents. The most diseases cited were congenital syphilis (72.5%) followed by malaria (7.5%) and hallucinations (7.5%). The whole plant is more used Original Research Article

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Pharmacological, Phytochemical and Their Application of Crotalaria L. Genus

Kumari,

Kumar

2022

SSRN Journal

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Duration of an induced resistance of sheep to acute poisoning by Crotalaria retusa seeds

Abstract: The aim of this study was to determine the duration of the resistance after the end of the ingestion of non-toxic doses of

Cited by 3 publications

References 10 publications

Estudo sobre a sensibilidade dos caprinos à toxidez de crotalárias tóxicas para bovinos visando a sua utilização na profilaxia

Estudo sobre a sensibilidade dos caprinos à toxidez de crotalárias tóxicas para bovinos visando a sua utilização na profilaxia

Ethno-medicinal Use of Crotalaria retusa L. (Fabaceae), a Pyrrolizidine Alkaloid Toxic Plant

Pharmacological, Phytochemical and Their Application of Crotalaria L. Genus

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