Diferentes doses de tramadol em cães: ações analgésicas, sedativas e sobre o sistema cardiorrespiratório

Paolozzi, Rodrigo Jesus; Cassu, Renata Navarro; Cruz, Fernando Silvério Ferreira da; Parrilha, Letícia Rodrigues

doi:10.1590/s0103-84782011000800019

Cited by 8 publications

(10 citation statements)

References 12 publications

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“…Wilson et al (2005) referiram que a êmese causada no pré-operatório não é condição determinante para o refluxo gastroesofágico transoperatório, embora a morfina já tenha sido descrita como fármaco precipitador desse evento (Barczinski e MoraesFilho, 2006). Paolozzi et al (2011) observaram elevada incidência (50%) de êmese nas cadelas que receberam 4mg.kg -1 de tramadol, porém essas o receberam por via intravenosa. A metadona apresenta vantagem em relação aos outros opioides, como morfina e hidromorfona, por não provocar êmese em cães (Valverde et al, 1989;Maiante et al, 2009).…”

Section: Resultsunclassified

Refluxo gastroesofágico em cadelas durante ovário-histerectomia convencional submetidas a diferentes medicações pré-anestésicas

Hartmann

Feranti

Oliveira

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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RESUMOA doença do refluxo gastroesofágico decorre do fluxo de conteúdo gastroduodenal para o esôfago e/ou para os órgãos adjacentes, o que leva à ampla gama de sinais e implicações clínicas. É desconhecida a incidência de refluxo gastroesofágico transoperatório em caninos. O objetivo deste trabalho foi, por meio da endoscopia flexível, avaliar a presença do refluxo gastroesofágico em cadelas submetidas a ovário-histerectomia com base nos fármacos analgésicos utilizados na medicação pré-anestésica (morfina, tramadol ou metadona). Concluiu-se que não houve diferença na incidência de refluxo gastroesofágico transoperatório, não tendo os fármacos testados influenciado de forma diferente esse comportamento; porém, alguns animais do grupo morfina apresentaram êmese pré-operatória. A gravidade dos refluxos foi maior nas cadelas submetidas ao uso da metadona, de acordo com o método de avaliação utilizado para esta pesquisa. Moraes-Filho, 2006; Carvalhaes et al., 2011; Abrahão Jr., 2014). Várias espécies são acometidas por esse evento e diversas podem ser as etiologias (Favarato et al., 2010).Recebido em 27 de outubro de 2016 Aceito em 3 de dezembro de 2016 *Autor para correspondência (corresponding author) E-mail: mauriciovelosobrun@hotmail.com Em cães, a anestesia geral é uma das principais causas de esofagite, devido à redução do tônus esfíncter esofagogástrico, precipitada por alguns fármacos (Favarato et al., 2010). O RGE pode incorrer em algumas consequências, tais como: azia, regurgitação, esofagite (Münster et al., 2013); pneumonia aspirativa (Nogueira et al., 2003) e estenose esofágica (Vlasin et al., 2004;Silva et al., 2010;Oliveira et al., 2013). O RGE em humanos ainda está fortemente associado ao http://dx

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Section: Resultsunclassified

Refluxo gastroesofágico em cadelas durante ovário-histerectomia convencional submetidas a diferentes medicações pré-anestésicas

Hartmann

Feranti

Oliveira

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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“…On the other hand, in an experimental cranial cruciate ligament replacement surgery, isolated ED tramadol at a dosage of 1.0 mg kg-1 was efficient (GUEDES et al, 2002). Other authors reporting on studies using ropivacaine and tramadol alone or in combination did not consider the analgesic effect during the transoperative period, and evaluated only the postoperative period (PAOLOZZI et al, 2011;MASTROCINQUE et al, 2012;MORGAZ et al, 2013;SOUZA et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…The EVA scale is related to the physiological parameters FC and PAS in order to minimize the errors during interpretation (LANDA, 2012). The pain is assessed before and after the administration of the drug by the same observer who was blinded to the treatments (CARREGARO et al, 2010;POHL et al, 2011POHL et al, , 2012PAOLOZZI et al, 2011;SOUZA et al, 2013). Table 1 shows that the HR values at M120 and M240 and the F values at M180 and M240 are higher for the GR group.…”

Section: Resultsmentioning

confidence: 99%

“…The assessment of pain in animals is based on both the physiological parameters and the behavioral aspects, and because of their subjectivity, these assessments are difficult to perform (BRONDANI et al, 2004;PAOLOZZI et al, 2011;POHL et al, 2011;LANDA, 2012;MORGAZ et al, 2013). Physiological parameters are critical to the assessment of pain, especially during the transoperative period, and include, among other variables, heart rate (HR), respiratory rate (F), body temperature (T, ºC), and blood pressure (BP) (BRONDANI et al, 2004;LANDA, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Tramadol does not cause severe hypotension and histamine release (MARUCIO; COTES, 2012). It produces minimal depressant effects in the CNS and cardiorespiratory system, observed in other opioids, and features a postoperative analgesic effect for 4 to 12 hours, similar to morphine (GUEDES et al, 2002;BASSO et al, 2008;KARGI et al, 2008;MCMILLAN et al, 2008;PAOLOZZI et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Effects of epidural anesthesia with tramadol, ropivacaine or tramadol-ropivacaine combination, in bitches undergoing ovariohysterectomy under anesthesia with isoflurane

Winter

Monzem

Spiller

et al. 2016

SCA

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Epidural anesthesia is a locoregional anesthetic technique that provides analgesia and muscle relaxation in the-retroumbilical region. The combination of opioids and local anesthetics increased the intensity and duration of analgesia by causing immediate motor and sensory nerve blockade, and improved recovery after surgery. The objective was to comparatively evaluate the trans- and postoperative cardiorespiratory and analgesic effects of epidurally administered tramadol, ropivacaine and tramadol-ropivacaine combination in dogs undergoing elective ovariohysterectomy. The effect of isoflurane concentration was also evaluated. This study was performed on 24 female mongrel dogs, pre-medicated with chlorpromazine (0.5 mg kg-1, IV) and, anesthetized with propofol and isoflurane. The dogs were randomly divided into three groups. The first group receveid epidural tramadol (2 mg kg-1, GT group), the second group received ropivacaine (1.5 mg kg-1, GR group), and the third group received a tramadol-ropivacaine combination at the above-mentioned doses (GTR group). At pre-defined time points, classified into pre-, trans-, and postoperative periods, cardiorespiratory variables and analgesia were analyzed for a period of up to 420 min following epidural anesthesia. The check analgesia was check of approximately 105, 217 and 382 minutes, in GR, in GT and GTR respectively, and no cardiovascular and respiratory depression. The drugs used in this study are considered safe and effective for ovariohysterectomy due to the cardiorespiratory stability and trans-operative analgesia provided by them. However, the combination of ropivacaine and tramadol ensured a greater reduction in the inhaled anesthetic dose and better analgesia during in the postoperative period.

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Microdialysis Coupled with Capillary Electrophoresis Method for Continuous Monitoring of Free Tramadol in Rabbit Blood

Wang¹

2014

Asian J. Chem.

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The new analytical method for the determination of protein-free tramadol in rabbit blood has been developed based on microdialysiscapillary electrophoresis method. Microdialysis probe was implanted into the ear vein of the rabbits. Separation and detection were carried out on a Beckman P/ACE 5000 equipped with UV-absorbance detector using a filter of 214 nm. This assay was successfully applied to a pharmacokinetic study involving intravenous administration of a single dose of tramadol hydrochloride to rabbits.

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Diferentes doses de tramadol em cães: ações analgésicas, sedativas e sobre o sistema cardiorrespiratório

Abstract: RESUMO Objetivou

Cited by 8 publications

References 12 publications

Refluxo gastroesofágico em cadelas durante ovário-histerectomia convencional submetidas a diferentes medicações pré-anestésicas

Refluxo gastroesofágico em cadelas durante ovário-histerectomia convencional submetidas a diferentes medicações pré-anestésicas

Effects of epidural anesthesia with tramadol, ropivacaine or tramadol-ropivacaine combination, in bitches undergoing ovariohysterectomy under anesthesia with isoflurane

Microdialysis Coupled with Capillary Electrophoresis Method for Continuous Monitoring of Free Tramadol in Rabbit Blood

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