Morfologia e desenvolvimento ultraestrutural do sistema renal de embriões bovinos com idade gestacional entre 10 e 50 dias

Cagnoto, Daniela Gomes; Guerra, Ricardo Romão; Alberto, Miryan Lança Vilia; Ambrósio, Carlos Eduardo; Santos, João Paulo Fernandes; Miglino, María Angélica

doi:10.1590/s0103-84782009005000155

Cited by 6 publications

(4 citation statements)

References 8 publications

(6 reference statements)

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“…Embryonic CNS development studies are extremely relevant to the organogenesis and its congenital abnormalities probable causes comprehension (Cagnoto et al 2009). In addition, the greatest susceptibility to teratogens is the embryonic period (Evans & Sack 1973), the stage in which the primitive germ layers form the major organs.…”

Section: Introductionmentioning

confidence: 99%

Bovine central nervous system development

et al. 2018

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Central nervous system (CNS) development researches are extremely important to the most common congenital disorders and organogenesis comprehension. However, few studies show the entire developmental process during the critical period. Present research can provide data to new researches related to normal development and abnormalities and changes that occur along the CNS organogenesis, especially nowadays with the need for preliminary studies in animal models, which could be used for experimental research on the influence of viruses, such as the influence of Zika virus on the development of the neural system and its correlation with microcephaly in human newborns. Then, present study describes CNS organogenesis in cattle according to microscopic and macroscopic aspects, identifying structures and correlating to gestational period. Fourteen embryos and nine bovine fetuses at different ages were collected and analyzed. All individuals were measured in order to detect the gestational period. Bovine embryo at 17 days age has its neural tube, cranial neuropore, caudal neuropore and somites developed. After 24 days of development, were observed in cranial part of neural tube five encephalic vesicles denominated: telencephalon, diencephalon, mesencephalon, metencephalon and myelencephalon. In addition, the caudal part of neural tube was identified with the primitive spinal cord. The primordial CNS differentiation occurred from 90 to 110 days. The five encephalic vesicles, primordial spinal cord and the cavities: third ventricule, mesencephalic aqueduct, fourth ventricle and central canal in spinal cord were observed. With 90 days, the main structures were identified: (1) cerebral hemispheres, corpus callosum and fornix, of the telencephalon; (2) interthalamic adhesion, thalamus, hypothalamus and epythalamus (glandula pinealis), of the diencephalon; (3) cerebral peduncles and quadruplets bodies, of the mesencephalon; (4) pons and cerebellum, of the metencephalon; (5) medulla oblongata or bulb, of the myelencephalon; and (6) spinal cord, of the primitive spinal cord. After 110 days of gestation, the five encephalic vesicles and its structures were completely developed. It was noted the presence of the spinal cord with the cervicothoracic and lumbossacral intumescences. In summary, the results describes the formation of the neural tube from the neural plate of the ectoderm, the encephalic vesicles derived from the neural tube and subsequent structural and cavities subdivisions, thus representing the complete embryology of the central nervous system.

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Section: Introductionmentioning

confidence: 99%

Bovine central nervous system development

et al. 2018

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“…Furthermore, studies on the development of the central nervous system are imperative for understanding the processes of organogenesis and the probable causes of congenital abnormalities (Cagnoto et al, 2009). HE staining can be used to study the normal development of the central nervous system (Costa et al, 2019; Ekici et al, 2014; Lakshmi, Sumitra, & Victor, 2013).…”

Section: Discussionmentioning

confidence: 99%

Central nervous system development in rabbits (Oryctolagus cuniculus L. 1758)

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Morais‐Pinto

et al. 2021

The Anatomical Record

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The present study describes the embryonic and fetal development of the central nervous system in rabbits from the seventh day after conception until the end of the full-term fetal period. A total of 19 embryonic and fetal samples were carefully dissected and microscopically analyzed. Neural tube closure was observed between 7.5 and 8 days of gestation. Primordial encephalic vesicle differentiation and spinal canal delimitation were observed on the 12th day of gestation. Histologically, on the 15th day of gestation, the brain, cerebellum, and brain stem were delimited. On the 18th day of gestation, the cervical and lumbar intumescences of the spinal cord were visible. On the 28th day of gestation, four-cell layers could be distinguished in the cerebral cortex, while the cerebellar cortex was still differentiating. Overall, the morphological aspects of the embryonic and fetal developmental phases in rabbits were highly similar to those in humans. Thus, the present study provides relevant information highlighting rabbits as an excellent candidate animal model for preclinical research on human neurological diseases given the high adaptability of rabbits to bioterium conditions and the similarity of morphological events between rabbits and humans.

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“…The understanding of horse conceptus development during the entire period of gestation is important as there are substantial pregnancy rate failures in this species (Sharp, ). In addition, studies on embryonic development are important to clarify several unclear aspects of organogenesis and causes of congenital malformations (Ushizawa et al, ; Cagnoto et al, ). Furthermore, basic knowledge of musculoskeletal system development is necessary for innovations in musculoskeletal junction and muscular therapies.…”

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confidence: 99%

“…formations (Ushizawa et al, 2004;Cagnoto et al, 2009). Furthermore, basic knowledge of musculoskeletal system development is necessary for innovations in musculoskeletal junction and muscular therapies.…”

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Organogenesis of the Musculoskeletal System in Horse Embryos and Early Fetuses

Barreto

Rodrigues

Carvalho

et al. 2016

The Anatomical Record

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Musculoskeletal system development involves heterotypical inductive interactions between tendons, muscles, and cartilage and knowledge on organogenesis is required for clarification of its function. The aim of this study was to describe the organogenesis of horse musculoskeletal system between 21 and 105 days of gestation, using detailed macroscopic and histological analyses focusing on essential developmental steps. At day 21 of gestation the skin was translucid, but epithelial condensation and fibrocartilaginous tissues were observed on day 25 of pregnancy. Smooth muscle was seen in lymphatic and blood vessel walls and the beginning of cartilaginous chondrocranium was detected at day 30 of gestation. At day 45, typical chondroblasts and chondrocytes were observed and at day 55, mandibular processes expanded toward the ventral midline of the pharynx. At day 75, muscles became thicker and muscle fibers were seen developing in carpal and metacarpal joints with the beginning of the ossification process. At day 105, major muscle groups, similar to those seen in an adult equine, were observed. The caudal area of the nasal capsule and trabecular cartilages increased in size and became ossified, developing into the ethmoid bone. The presence of nasal, frontal, parietal, and occipital bones was observed. In conclusion, novel features of equine musculoskeletal system development have been described here and each process was linked with an early musculoskeletal event. Data presented herein will facilitate a better understanding of the equine muscular system organogenesis and aid in the detection of congenital deformities. Anat Rec,

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Morfologia e desenvolvimento ultraestrutural do sistema renal de embriões bovinos com idade gestacional entre 10 e 50 dias

Abstract: IMorfologia e desenvolvimento ultraestrutural do sistema renal de embriões bovinos com idade gestacional entre 10 e 50 diasMorphology and ultrastructural development of renal system in bovine embryos with gestational age between 10 and 50 days

Cited by 6 publications

References 8 publications

Bovine central nervous system development

Bovine central nervous system development

Central nervous system development in rabbits (Oryctolagus cuniculus L. 1758)

Organogenesis of the Musculoskeletal System in Horse Embryos and Early Fetuses

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