Patogenicidade de um isolado de Trypanosoma evansi em ratos inoculados com o parasito em sangue in natura e criopreservado

Silva, Aleksandro S. Da; Wolkmer, Patrícia; Gressler, Lucas T.; Otto, Mateus Anderson; Bess, Franciele; Tavares, Kaio César Simiano; Zanette, Régis Adriel; Monteiro, Sílvia González

doi:10.1590/s0103-84782009000600031

Cited by 11 publications

(4 citation statements)

References 12 publications

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“…According to Da Silva et al . (2009 a ) the longevity of rats may be related to the type of inoculum used. When they are made by successive infections in rats, there is an acute phase with high parasitaemia and death of animals within 5 days p.i.…”

Section: Discussionmentioning

confidence: 99%

“…Although authors reported that R. norvegicus is a suitable model for the study of the parasitaemic wave of T. evansi (Queiroz et al 2000), the typical undulating course of parasitaemia was observed in group B of this experiment. According to Da Silva et al (2009a) the longevity of rats may be related to the type of inoculum used. When they are made by successive infections in rats, there is an acute phase with high parasitaemia and death of animals within 5 days p.i.…”

Section: Discussionmentioning

confidence: 99%

“…The number of inoculated flagellates was estimated by using a Neubauer chamber (Wolkmer et al 2007). This study aimed to evaluate the acute and chronic disease in the rat, so the infectious dose used for groups A and B was 2 × 10 6 trypomastigotes/ animal in fresh blood and cryopreserved blood, respectively (Da Silva et al 2009a). The collection of samples from animals in group A was performed on day 4 post-infection (p.i.)…”

Section: A T E R I a L S A N D M E T H O D Smentioning

confidence: 99%

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Activity of the enzyme adenosine deaminase in serum, erythrocytes and lymphocytes of rats infected with Trypanosoma evansi

et al. 2010

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In Trypanosoma evansi infections changes in the haemogram are commonly observed, and the enzyme adenosine deaminase (ADA) plays an important role in the production and differentiation of blood cells. Thus, the aim of this study was to evaluate the activity of ADA in serum, erythrocytes and lymphocytes of rats infected with T. evansi compared to non-infected rats. Thirty adult rats were used, divided into 3 uniform groups. The animals in groups A and B were infected intraperitoneally with 2 x 10⁶ trypomastigotes/rat. Rodents from group C (control group), were not-infected. Blood collection was performed on days 4 and 20 post-infection (p.i.) in order to obtain acute and chronic infection stages of disease. The blood was used to assess the activity of ADA. In the blood, reduced haematocrit and increased lymphocytes were correlated with ADA activity in erythrocytes and lymphocytes. We observed reduction of ADA activity in serum and erythrocytes in rats infected with T. evansi compared to non-infected rats (P < 0.05). ADA activity in lymphocytes was decreased after 4 days, when the parasitaemia was high and increased after 20 days, when the number of circulating parasites was low. In conclusion, our results showed that the ADA activity was altered in serum, lymphocytes and erythrocytes of rats, concomitantly with haematological parameters, in experimental infection by T. evansi.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: A T E R I a L S A N D M E T H O D Smentioning

confidence: 99%

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Activity of the enzyme adenosine deaminase in serum, erythrocytes and lymphocytes of rats infected with Trypanosoma evansi

et al. 2010

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“…Namun, hasil PCR masih menunjukkan hasil positif untuk mencit-mencit yang diobati dengan darah atau plasma manusia normal. Hasil tersebut diduga karena puncak parasitemia dalam darah tidak beraturan siklusnya (irregular parasitemic peaks) akibat respon imun mencit (Da Silva et al 2009).…”

Section: Faktor Trypanolitik Pada Trypanosomaunclassified

Surra: Trypanosomiasis in Livestock is Potential as Zoonotic Disease

Wardhana¹,

Savitri²

2018

WARTAZOA

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Trypanosoma evansi is one of blood protozoans having the most wide distribution region compared to other Trypanosome species. The parasite causes trypanosomiasis known as Surra. The disease may cause mortality to the infected animals. In general T evansi only attack animal and cannot infect humans due to apolipoprotein 1 (Apo L-1) in human serum. The protein possess trypanolitic activity feature against T. evansi and effectively eliminates the protozoa. However, the knowledge of Surra infecting animals changed because there were atypical human trypanosomiasis cases reported in some countries due to T. evansi. The human Surra case occurred in Vietnam demonstrated that person with Apo L-1 could be infected by T. evansi. There was resistant strain of T. evansi found which able to disrupt human immune system. This paper will discuss Surra cases in both humans and animals, including mechanism of Apo L-1 on eliminating the parasite. Surra cases in human and animal should be seriously concerned because Surra could be pontential zoonosis threating human health.

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Trypanosoma evansi infection on levels of copper, iron, and zinc in the plasma of rats

et al. 2012

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Patogenicidade de um isolado de Trypanosoma evansi em ratos inoculados com o parasito em sangue in natura e criopreservado

Cited by 11 publications

References 12 publications

Activity of the enzyme adenosine deaminase in serum, erythrocytes and lymphocytes of rats infected with Trypanosoma evansi

Activity of the enzyme adenosine deaminase in serum, erythrocytes and lymphocytes of rats infected with Trypanosoma evansi

Surra: Trypanosomiasis in Livestock is Potential as Zoonotic Disease

Trypanosoma evansi infection on levels of copper, iron, and zinc in the plasma of rats

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