Alterações hematológicas em coelhos infectados experimentalmente pelo Trypanosoma evansi

Silva, Aleksandro S. Da; Costa, Márcio Machado; Lopes, Sônia Terezinha dos Anjos; Monteiro, Sílvia González

doi:10.1590/s0103-84782008000200040

Cited by 17 publications

(6 citation statements)

References 9 publications

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“…As literature, the proposed mechanisms are erythrophagocytosis, destruction of the erythrocytes by the immune system, erythrocyte osmotic fragility, hemodilution, erythropoietic depression, and oxidative stress (Maudlin et al, 2004;Wolkmer et al, 2009;Da Silva et al, 2011). This is a common finding in dogs, goats, horses and cats naturally or experimentally infected (Colpo et al, 2005;Da Silva et al, 2008;Dalla Rosa et al, 2013;Rodrigues et al, 2005). The mean of MCV and MCHC did not differ among groups, characterizing a normocyticnormochromic anemia.…”

Section: Discussionmentioning

confidence: 99%

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo

Baldissera

Vaucher

et al. 2015

Experimental Parasitology

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Section: Discussionmentioning

confidence: 99%

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo

Baldissera

Vaucher

et al. 2015

Experimental Parasitology

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“…Trypanosoma evansi is a digenetic flagellate implicated in the infection of a large number of domestic and wild animals, such as equines, canines, felines, rabbits, capybaras, ring-tailed coatis, bovines and buffaloes (Dávila and Silva, 2000; Herrera et al 2004; Tarello, 2005; Da Silva et al 2008) and humans (Joshi et al 2005). This protozoan is the agent of trypanosomosis, a disease with broad distribution in Africa, Asia, and Latin America (Lun and Desser, 1995).…”

Section: Introductionmentioning

confidence: 99%

Activity of the enzyme adenosine deaminase in serum, erythrocytes and lymphocytes of rats infected with Trypanosoma evansi

et al. 2010

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In Trypanosoma evansi infections changes in the haemogram are commonly observed, and the enzyme adenosine deaminase (ADA) plays an important role in the production and differentiation of blood cells. Thus, the aim of this study was to evaluate the activity of ADA in serum, erythrocytes and lymphocytes of rats infected with T. evansi compared to non-infected rats. Thirty adult rats were used, divided into 3 uniform groups. The animals in groups A and B were infected intraperitoneally with 2 x 10⁶ trypomastigotes/rat. Rodents from group C (control group), were not-infected. Blood collection was performed on days 4 and 20 post-infection (p.i.) in order to obtain acute and chronic infection stages of disease. The blood was used to assess the activity of ADA. In the blood, reduced haematocrit and increased lymphocytes were correlated with ADA activity in erythrocytes and lymphocytes. We observed reduction of ADA activity in serum and erythrocytes in rats infected with T. evansi compared to non-infected rats (P < 0.05). ADA activity in lymphocytes was decreased after 4 days, when the parasitaemia was high and increased after 20 days, when the number of circulating parasites was low. In conclusion, our results showed that the ADA activity was altered in serum, lymphocytes and erythrocytes of rats, concomitantly with haematological parameters, in experimental infection by T. evansi.

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“…Researchers have used plasma therapy from different hosts to treat trypanosomosis (WECHSLER; KONGSHAVN, 1988;OTTO et al, 2009). Studies have shown that rabbits are very resistant to T. evansi infection (UCHE et al, 1992;SILVA et al, 2007;2008a), but this resistance is not yet clear. It is probably associated with proteins with trypanocidal activity found in Figure 1.…”

Section: Discussionmentioning

confidence: 99%

Trypanocidal activity of human plasma on Trypanosoma evansi in mice

Silva

Duck

Fanfa

et al. 2012

Rev. Bras. Parasitol. Vet.

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This study aimed to test an alternative protocol with human plasma to control Trypanosoma evansi infection in mice. Plasma from an apparently 27-year-old healthy male, blood type A+, was used in the study. A concentration of 100 mg.dL-1 apolipoprotein L1 (APOL1) was detected in the plasma. Forty mice were divided into four groups with 10 animals each. Group A comprised uninfected animals. Mice from groups B, C and D were inoculated with a T. evansi isolate. Group B was used as a positive control. At three days post-infection (DPI), the mice were administered intraperitoneally with human plasma. A single dose of 0.2 mL plasma was given to those in group C. The mice from group D were administered five doses of 0.2 mL plasma with a 24 hours interval between the doses. Group B showed high increasing parasitemia that led to their death within 5 DPI. Both treatments eliminated parasites from the blood and increased the longevity of animals. An efficacy of 50 (group C) and 80% (group D) of human plasma trypanocidal activity was found using PCR. This therapeutic success was likely achieved in the group D due to their higher levels of APOL1 compared with group C.

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Alterações hematológicas em coelhos infectados experimentalmente pelo Trypanosoma evansi

Abstract: RESUMO O objetivo deste trabalho foi avaliar as alterações hematológicas em coelhos infectados experimentalmente pelo

Cited by 17 publications

References 9 publications

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Activity of the enzyme adenosine deaminase in serum, erythrocytes and lymphocytes of rats infected with Trypanosoma evansi

Trypanocidal activity of human plasma on Trypanosoma evansi in mice

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