Resposta eritropoética de ratos em diferentes graus de parasitemia por Trypanosoma evansi

Wolkmer, Patrícia; Silva, Aleksandro S. Da; Cargnelutti, Juliana Felipetto; Costa, Márcio Machado; Traesel, Carolina Kist; Lopes, Sônia Terezinha dos Anjos; Monteiro, Sílvia González

doi:10.1590/s0103-84782007000600027

Cited by 34 publications

(13 citation statements)

References 18 publications

(8 reference statements)

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“…The mean of MCV and MCHC did not differ among groups, characterizing a normocyticnormochromic anemia. These results have been reported in other studies in mice, rats and horses Franciscato et al, 2007;Wolkmer et al, 2007). Treatment with A. satureioides nanostructured form is beneficial, because it avoided a sharp reduction in red blood cells, i.e.…”

Section: Discussionsupporting

confidence: 86%

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo

Baldissera

Vaucher

et al. 2015

Experimental Parasitology

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Section: Discussionsupporting

confidence: 86%

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Carmo

Baldissera

Vaucher

et al. 2015

Experimental Parasitology

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“…Regenerative anemia was described in rats infected with T. evansi (Wolkmer et al 2007). Although the trypanosomes are responsible for the development of anemia (Ogbadoyi et al 1999), this mechanism is not completely elucidated.…”

Section: Resultsmentioning

confidence: 99%

“…They were inoculated intraperitoneally (day 1) with a strain of T. evansi that had been obtained from a naturally infected dog (Colpo et al 2005) and had been kept in liquid nitrogen. The number of inoculated flagellates was estimated by using a Neubauer chamber (Wolkmer et al 2007). The infected group received 10 8 infectious trypomastigote forms of T. evansi, whereas the control group received a physiological solution.…”

Section: Methodsmentioning

confidence: 99%

Lipid peroxidation in cats experimentally infected with Trypanosoma evansi

et al. 2009

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The objective of this study was to evaluate the lipid peroxidation and the susceptibility of erythrocytes to in vitro peroxidation as indicators of oxidative damage in erythrocytes and their roles in the pathogenesis of anemia during experimental Trypanosoma evansi infection in cats. Animals were divided into two groups: control and infected with T. evansi. Seven cats were infected with 10(8) trypomastigotes each, and parasitemia was estimated daily for 49 days by microscopic examination of smears. Hematological and biochemical parameters were evaluated for monitoring of the disease. Plasma lipid peroxidation (Thiobarbituric Acid Reactive Substances (TBARS)) and the susceptibility of erythrocytes to in vitro peroxidation were evaluated. Blood samples for analysis were collected at days 21 and 49 post-inoculation. TBARS level, indicated by MDA concentration, was higher in the infected group than in the control group in both analyzed periods, as well as the in vitro erythrocyte peroxidation (P < 0.001). The infected cats had variable degrees of regenerative anemia, which could be explained by the damage in erythrocyte membrane caused by lipid peroxidation.

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“…Control group received physiological solution by the same route. The number of inoculated flagellates was estimated by Neubauer chamber (Wolkmer et al 2007).…”

Section: Animalsmentioning

confidence: 99%

Cholinesterase as inflammatory markers in a experimental infection by Trypanosoma evansi in rabbits

Costa

Silva

Paim

et al. 2012

An. Acad. Bras. Ciênc.

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The aim of this study is to evaluate the role of cholinesterases as an inflammatory marker in acute and chronic infection by Trypanosoma evansi in rabbits experimentally infected. Twelve adult female New Zealand rabbits were used and divided into two groups with 6 animals each: control group (rabbits 1-6) and infected group (rabbits 7-12). Infected group received intraperitoneally 0.5 mL of blood from a rat containing 108 parasites per animal. Blood samples used for cholinesterases evaluation were collected on days 0, 2, 7, 12, 27, 42, 57, 87, 102 and 118 days post-inoculation (PI). Increased activity (P<0.05) of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) were observed in the blood on days 7 and 27, respectively and no differences were observed in cholinesterase activity in other periods. No significant difference in AChE activity (P>0.05) was observed in the encephalic structures. The increased activities of AChE and BChE probably have a pro-inflammatory purpose, attempting to reduce the concentration of acetylcholine, a neurotransmitter which has an anti-inflammatory property. Therefore, cholinesterase may be inflammatory markers in infection with T. evansi in rabbits.

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Resposta eritropoética de ratos em diferentes graus de parasitemia por Trypanosoma evansi

Abstract: RESUMO

Cited by 34 publications

References 18 publications

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi

Lipid peroxidation in cats experimentally infected with Trypanosoma evansi

Cholinesterase as inflammatory markers in a experimental infection by Trypanosoma evansi in rabbits

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