“…CAP has been widely used due to its low cost and high efficiency in the treatment of various infectious diseases. Due to its carcinogenic effects and other serious adverse reactions, such as bone marrow depression, aplastic anemia and severe blood disorders, CAP has been banned from China, Japan, Canada, United States, Australia and European Union in animals used for human consumption, even if it is still legally used in Brazil and other countries, or illegally, in livestock, due to the easy access, low price and steady antibacterial effectiveness (Andrade et al, 2006). As consequence CAP has been found in concentrations between 0.001 and 0.031 μg L À 1 in surface waters in Singapore and Korea, respectively.…”