Anestesia para mielografia em cães

Leite, Alessandra Valeiro; Nunes, Newton; Rezende, Marlis L.

doi:10.1590/s0103-84782002000400029

Cited by 10 publications

(11 citation statements)

References 6 publications

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“…In rabbits, the onset of seizures was observed between 5 and 60 min after injection of the substance was completed . The findings of this study seem to reflect the neurotoxic effect of iobitridol and iohexol, as seizures are commonly reported as neurotoxic effects of CMs, especially when the applications are made through the cisterna magna (LEITE et al, 2002). Other potential causative factors include, an increased duration of anesthesia (this was greater in the animals where higher doses of CM were used, in order to maintain the administration rate), an increased intracranial pressure (which can contribute to the reduction of cerebral circulation and lead to the development of neurological complications after the application of the CM) (ARANY-TÓTH et al, 2013), and the anesthetic protocol used (LEITE et al, 2002).…”

Section: Mgmentioning

confidence: 52%

“…These include, rat contention for cisterna magna puncturing (to carry out the pilot of this work, we tried the technique described by Jeffers and Griffith (1942), apud Waynforth and Flecknell (1992), and by Melartin et al (1970), however, when performing the radiography control, a significant extravasation of CM through the subarachnoid space was found), the concentration of the CM used (higher iodine concentrations reflected an increase in osmolality and consequent increased risk of side effects) (FATONE et al, 1997), the anesthetic protocol used (this can affect the respiratory depression; such as isoflurane, which has a direct influence on medullar ventilation center and indirect effect on the intercostal muscles), the rate of administration (hasty administration can cause the CM to flow into the rostral subarachnoid space accumulating in the fourth ventricle and cerebellar hemisphere, increasing the intracranial pressure, indicated by clinical signs including bradycardia and apnea that are related to a reduction of cerebral blood flow) (LEITE et al, 2002;ARANY-TÓTH et al, 2013) and preheating the CM (with a rise of temperature, there is a viscosity reduction) (UCHIYAMA et al, 2006). Tables 1 and 2 shows the signs of depression and excitement, respectively, observed from 5 min to the application of the substance (iohexol, iobitridol or ACF) in five different doses.…”

Section: Resultsmentioning

confidence: 99%

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Comparative neurotoxicity of iobitridol with iohexol by intracisternal administration in Wistar rats

Mello

Stédile

Gouvêa

et al. 2017

SCA

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Iobitridol is a tri-iodinated contrast agent, and neurotoxicologic studies of the intracisternal administration are scarce and inconclusive. The purpose of this study was to compare the neurotoxicity of iobitridol with iohexol, by intracisternal administration in Wistar rats, for a pre-clinical evaluation of its use as a myelographic agent. The animals, a total of 75, were divided into three experimental groups, iobitridol, iohexol and cerebral artificial fluid (control group), with 25 animals per group. Then, these were divided into five subgroups of five animals each, and given doses of 200, 400, 600, 800 and 1000 mg kg -1 , while the control group received the equivalent volumes of contrast media tested. The animals were evaluated after 5, 15, 30, 60, 120, 180 and 240 min of intracisternal administration of these substances, for signs of depression and excitement, tactile palmar grasp, flexor, extensor, palpebral, papillary and pinna reflexes, surface righting and placing reactions, and with an auditory startle test. The evaluations were assessed daily for seven days with these parameters and their body weight, food, and water intake were also measured. There were no statistically significant differences between groups tested with respect to any of the evaluated parameters. In other words, in this animal model, the iobitridol demonstrated a low neurotoxicologic potential, comparable to that observed with iohexol. Further study with dogs and cats, as an alternative, is suggested. Key words: Contrast media. Cistern. Iodinated contrast. Myelography. Toxicity. ResumoO iobitridol é um meio de contraste tri-iodado, e estudos referentes à neurotoxicidade, com administração subaracnóide são escassos e inconclusivos. O objetivo deste trabalho foi comparar a neurotoxicidade do iobitridol com a do iohexol, por via intracisternal, em ratos Wistar, como avaliação pré-clínica da utilização deste como agente mielográfico. Foram utilizados 75 animais divididos em três grupos experimentais com 25 animais: iobitridol, iohexol e líquido cerebroespinhal artificial (grupo controle). Estes foram subdivididos em cinco subgrupos com cinco animais cada, com doses distintas de 200, 400, 600, 800 e 1000 mg kg -1 , sendo utilizado no grupo controle o volume equivalente aos meios de contraste testados. Os animais foram avaliados após 5, 15, 30, 60, 120, 180 palmar, flexor, extensor, palpebral, pupilar e da pina, reação de endireitamento e posicionamento e resposta auditiva. Nos sete dias subsequentes, os animais foram avaliados diariamente quanto a estes parâmetros, e ainda a massa corporal, a ingestão de ração e de água, foram mensuradas. Não foram observadas diferenças estatisticamente significativas entre os grupos testados com meios de contraste, em nenhum dos parâmetros avaliados. Dessa forma, nesse modelo animal, o iobitridol demonstrou baixa neurotoxicidade, comparável a observada com o iohexol. Sugerem-se mais estudos com cães e gatos para utilização do iobitridol como alternativa. . Palavras-chave: Cisterna. Contraste ...

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Section: Mgmentioning

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Comparative neurotoxicity of iobitridol with iohexol by intracisternal administration in Wistar rats

Mello

Stédile

Gouvêa

et al. 2017

SCA

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“…The first record of myelographic examination conducted on people was in 1920, which consisted of the use of contrast medium, atmospheric air, or oxygen (BULLOCK; ZOOK, 1967;LEITE et al, 2002). In 1950, the first myelography was performed in dogs (PUGLISI et al, 1986;LEITE et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological aspects of myelography in dogs: 61 cases (2003–2012)

et al. 2014

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Myelography is a radiological contrast examination technique frequently used in the diagnosis of vertebral spine and spinal cord disorders. The procedure involves inserting a needle with subsequent injection of contrast medium, which delimits the spinal cord. The main indication is suspected spinal injuries not visualized on plain radiographs. Myelography is effective in the identification of the location of the lesion but is contraindicated in patients with infectious diseases or who have recently experienced trauma. Advantages of myelography are cost effectiveness in both the examination procedure and maintenance of equipment, and delivery of quality images, compared with other imaging methods in dogs. Disadvantages include a relatively long examination procedure, the need for general anesthesia, and the risk of seizures or death. The aim of this study was to characterize a population of dogs undergoing myelography according to the following factors: severity of injury, breed, age, sex, reproductive status, diet, weight, previous illnesses, vertebral region evaluated, lesion location in spinal cord or meninges, cause of radiographic signs, and possible complications. The database was created from information in medical records, and included 61 dogs with suspected disorders of the vertebral spine, spinal cord, and/or meninges that underwent myelography at the Unidade Hospitalar para Animais de Companhia of Pontifícia Universidade Católica do Paraná from January 2003 through December 2012. The results indicate that the most common degree of injury severity was Grade 2 (39.34% of the patients). The most prevalent breeds were mixed breed dogs (22.58%) and the dachshund (18.03%). Ages with higher frequency were 6 and 10 years (average, 7.6 years). According to sex and reproductive status, intact male (42.62%) and female (36.06%) dogs were most affected. The commercial (50.82%) and mixed (44.26%) diets were the most common diets. The body weight between 6 and 15 kg (37.70%) was the most significant. Most of the patients showed no previous diseases (73.77%). The thoracolumbar region was the most evaluated (47.22%). Most injuries were extramedullary (62.30%), and the most common cause was intervertebral disc disease (52.38%). The complications of myelography were not significant. It can be seen that the data in our environment tend to be similar to those of the national literature, but international literature is currently focusing on more sensitive tests such as CT and MRI. Key words: Myelography, vertebral spine, spinal cord, intervertebral disc disease in dogs ResumoA mielografia é utilizada no diagnóstico de doenças da coluna vertebral e medula espinhal. são suspeitas de lesões medulares não visualizadas em radiografias simples. Suas contraindicações são em pacientes com doenças infecciosas ou que sofreram trauma recente. Se comparada a outros métodos imaginológicos em cães, apresenta a vantagem de ter baixo custo do exame e de manutenção. Como desvantagem, apresenta maior tempo para a realização do exame,...

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“…In order to perform this technique, general anesthesia, constant monitoring and adequate ventilatory support are necessary (Leite et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Iohexol is a non-ionic, water soluble, contrast agent, used for myelography in dogs (Leite et al, 2002). The most used iohexol concentrations range from 180 to 350mg/mL (Simon and Nicholas, 1999).…”

Section: Introductionmentioning

confidence: 99%

Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

Nunes

Leite²,

Paula³

et al. 2011

Arq. Bras. Med. Vet. Zootec.

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Intracranial variables in propofol or ABSTRACTThe effects of subarachnoid administration of iohexol on intracranial hemodynamic in dogs anesthetized with propofol or sevoflurane were evaluated. Thirty adult animals (10.92.9kg) were distributed into two groups: PG, where propofol was used for induction (100.5mg/kg), followed by a continuous rate infusion at 0.550.15mg/kg/hour, and SG, where sevoflurane was administered for induction (2.5 MAC) and for anesthetic maintenance (1.5 MAC). A fiberoptic catheter was implanted on the right superficial cerebral cortex to monitor intracranial pressure (ICP). After 30 minutes, cerebrospinal fluid (CSF) was collected at the cisterna magna and iohexol was injected. The measurements were performed before CSF collection (TA), after the iohexol injection (T0), and at 10-minute intervals (T10 to T60). Intracranial pressure decreased at T0 in SG. Cerebral perfusion pressure at T0 was higher than at TA, T50 and T60 in PG, but in SG, the mean value at T0 was higher than the ones from T20 to T60. Mean arterial pressure at T0 was higher than at TA in PG, while in SG, the values from T20 to T60 were lower than at T0. The heart rate at T60 was lower than at T0 in PG. Cardiac output at TA was lower than at T60 in SG. The cerebrospinal fluid collection and administration of iohexol promoted decrease in intracranial pressure in sevolflurane-anesthetized dogs and increase in cerebral perfusion pressure in propofol-anesthetized dogs.Keywords: anesthesia, dogs, cerebral autoregulation, myelography Palavras-chave: cão, anestesia, autoregulação cerebral, mielografia RESUMO Avaliaram-se os efeitos da administração subaracnóidea de iohexol sobre a hemodinâmica intracraniana em cães anestesiados com propofol ou sevofluorano. Trinta e dois animais (10,9±2,9kg) foram distribuídos em dois grupos: no GP, o propofol foi usado para indução, 100.5mg/kg, seguido por infusão contínua, 0,55±0,15mg/kg/min; no GS, o sevofluorano foi administrado para indução, 2,5 CAM, e manutenção, 1,5 CAM, da anestesia. O cateter de fibra óptica foi implantado na superfície direita do córtex cerebral para monitorar a pressão intracraniana (PIC). Após 30 minutos, o fluido cerebroespinhal (FCS) foi coletado da cisterna magna e o iohexol injetado. As mensurações ocorreram antes da coleta do FCS (TA), depois da injeção de iohexol (T0) e em intervalos de 10 minutos (T10 a T60

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Anestesia para mielografia em cães

Abstract: RESUMO Com este texto, objetiva-se fornecer ao profissional de Medicina Veterinária subsídios para a realização de

Cited by 10 publications

References 6 publications

Comparative neurotoxicity of iobitridol with iohexol by intracisternal administration in Wistar rats

Comparative neurotoxicity of iobitridol with iohexol by intracisternal administration in Wistar rats

Epidemiological aspects of myelography in dogs: 61 cases (2003–2012)

Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

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