2001
DOI: 10.1590/s0103-84782001000100026
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Abstract: Cinqüenta e seis cabras morreram em aproximadamente 44 horas após serem medicadas com disofenol. Dois animais foram necropsiados. Pontos de coloração marrom claro, com aproximadamente 2cm de diâmetro foram observados na cápsula e superfície de corte do órgão. A superfície de corte dos rins apresentaram áreas claras intercaladas com áreas escuras. A bexiga urinária estava repleta com urina e sedimento. A cavidade abdominal, torácica e o saco pericárdico tinham acúmulo de fluído amarelado. Espuma foi encontrada … Show more

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Cited by 4 publications
(5 citation statements)
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“…Severe liver disease results in a reduction in most clotting factors (Mosier 2017), and the acute injury observed in the animals in this study may suggest a decrease in the production of these factors, and the consequent appearance of areas of hemorrhage. The hepatic alterations found were similar to those described in the literature for poisoning by phenolic substitutes (Soares et al 2001, Alves et al 2018, macroscopically characterized by appearance of lobular pattern. Microscopic findings of degeneration, necrosis, and sometimes centrilobular congestion have been described in cases of nitroxinil poisoning in sheep (Campello et al 2020), and in cases of disophenol poisoning in goats and sheep (Soares et al 2001, Alves et al 2018.…”
Section: Discussionsupporting
confidence: 85%
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“…Severe liver disease results in a reduction in most clotting factors (Mosier 2017), and the acute injury observed in the animals in this study may suggest a decrease in the production of these factors, and the consequent appearance of areas of hemorrhage. The hepatic alterations found were similar to those described in the literature for poisoning by phenolic substitutes (Soares et al 2001, Alves et al 2018, macroscopically characterized by appearance of lobular pattern. Microscopic findings of degeneration, necrosis, and sometimes centrilobular congestion have been described in cases of nitroxinil poisoning in sheep (Campello et al 2020), and in cases of disophenol poisoning in goats and sheep (Soares et al 2001, Alves et al 2018.…”
Section: Discussionsupporting
confidence: 85%
“…The hepatic alterations found were similar to those described in the literature for poisoning by phenolic substitutes (Soares et al 2001, Alves et al 2018, macroscopically characterized by appearance of lobular pattern. Microscopic findings of degeneration, necrosis, and sometimes centrilobular congestion have been described in cases of nitroxinil poisoning in sheep (Campello et al 2020), and in cases of disophenol poisoning in goats and sheep (Soares et al 2001, Alves et al 2018. The acute liver injury characterized by marked centrilobular necrosis is due to the greater amount of cytochrome P450 in the hepatocytes of this region, that induces the formation of reactive metabolites that are responsible for cell damage, in addition to the lower oxygen tension in this zone (Barros 2016, Brown et al 2017.…”
Section: Discussionsupporting
confidence: 85%
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“…Além disso, recomenda-se a realização de esquemas de tratamento e diagnóstico regular de adultos, haja vista o fato de que infecções repetidas podem ocorrer durante a vida do animal adulto(STULL et al, 2007).Disofenol é um produto sintético pertencente ao grupo dos Nitrofenóis, cujo modo de ação se baseia no bloqueio da respiração do helminto e consequente esgotamento das reservas energéticas, já que age interferindo na fosforilação oxidativa do helminto, através da inibição do sistema envolvido com a enzima fumarato-redutase. O uso desse medicamento pode causar taquicardia, lesões renais e hipertermia, que pode ser letal, particularmente após elevação da temperatura ambiental e após exercícios físicos(SOARES et al, 2001).A ivermectina é uma lactona macrocíclica derivada da avermectina B, sendo produzida pela fermentação do Streptomyces avarmetilis. A ação das avermectinas se dá pela potencialização dos efeitos do ácido gama-aminobutírico (GABA), dificultando desse modo a transmissão dos estímulos nervosos para os músculos, e, consequentemente, impedindo a contração da célula muscular.…”
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