Colesterol e composição dos ácidos graxos nas dietas para humanos e na carcaça suína

Lüdke, Maria do Carmo Mohaupt Marques; López, Jorge

doi:10.1590/s0103-84781999000100033

Cited by 14 publications

(5 citation statements)

References 28 publications

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“…Cholesterol is a lipid component that is necessary for normal functioning of the body, and it plays an important role in the structure and function of the plasma membrane as well as organelle membranes. Also, it is involved in the synthesis of bile acids required for the absorption of lipids and lipid-soluble vitamins from the intestine, and participates in the synthesis of steroid hormones and vitamin E (Ludke and López, 1999, Leança et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism

Andrade

Braga

Guedes

et al. 2017

Saudi Journal of Biological Sciences

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Menadione, vitamin K3, belongs to the class of lipid-soluble vitamins and lipophilic substances as menadione cause disturbances in the bacterial membrane, resulting in damage to the fundamental elements for the integrity of the membrane, thus allowing increased permeability. Accordingly, the aim of this study was to evaluate in vitro the antibiotic-modifying activity of menadione in multiresistant strains of , and , with a gradual increase in its subinhibitory concentration. In addition, menadione was compared with cholesterol and ergosterol for similarity in mechanism of drug modulatory action. Antibiotic-modifying activity and antibacterial effect were determined by the broth microdilution assay. Menadione, cholesterol and ergosterol showed modulatory activity at clinically relevant concentrations, characterizing them as modifiers of bacterial drug resistance, since they lowered the MIC of the antibiotics tested. This is the first report of the antibacterial activity of menadione and its potentiation of aminoglycosides against multiresistant bacteria.

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Section: Introductionmentioning

confidence: 99%

Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism

Andrade

Braga

Guedes

et al. 2017

Saudi Journal of Biological Sciences

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“…The atherosclerosis risk is twice to three times greater in diabetics than in non-diabetics. The absence of insulin promotes hydrolysis of stored triglycerides in the adipocytes and their presence in the circulation, and the leading to a reduction in serum levels of HDL-C [ 9 - 11 ].…”

Section: Introductionmentioning

confidence: 99%

A potential synbiotic product improves the lipid profile of diabetic rats

et al. 2012

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BackgroundPrevious studies showed that intake of yacon or some lactic acid bacteria was able to inhibit the development of diabetes mellitus, by reducing glucose and associated symptoms, for example, the lipid profile.ObjectiveThe purpose of this study was to assess the consumption influence of a potential symbiotic product of soybean and yacon extract and fermented Enterococcus faecium CRL 183 and Lactobacillus helveticus ssp jugurti 416 in reducing blood glucose and lipid levels in an animal model.MethodsDiabetes mellitus was chemically induced by intraperitoneal administration of streptozotocin (50 mg/kg body weight). The rats were divided into four groups (n=10): GI – non-diabetic animals that received only a standard chow diet (negative control), GII – diabetic animals that received only chow diet (positive control), GIII – diabetic animals that received the chow diet + 1 mL/kg body weight/day of soybean and yacon unfermented product, GIV – diabetic rats that received the chow diet + 1 mL/kg body weight/day of soybean and yacon fermented product. There was a seven-week treatment period and the following parameters were evaluated: animal body weight, food and water intake, blood glucose, enzyme activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), triglycerides levels, total cholesterol, HDL-C, non-HDL-C. Cell viability of the fermented product was checked weekly for a seven-week period.ResultsThe product average viable population was 108-109 CFU/mL, by ensuring both the rods and cocci regular intake. No difference was observed between the water and feed intake and body weight of groups that received unfermented and fermented products and the untreated diabetic group. The same was observed for the blood glucose and AST and ALT activities, while some improvement was observed for a lipid profile, represented by reduction of triglycerides level by 15.07% and 33.50% in groups III and IV, respectively, and an increase of 23.70% in HDL-C level for group IV.ConclusionThe results showed that the ingestion of a potential symbiotic product was neither able to promote improvement in some of the disease symptoms, nor reduce blood glucose. However, a positive effect on triglycerides levels and HDL-cholesterol was observed in the groups that received the unfermented product containing yacon extract and the fermented product with Enterococcus faecium CRL 183, as well as Lactobacillus helveticus ssp jugurti 416 and yacon extract (symbiotic product).

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“…O protocolo de sililação de ligação C-H seguida por oxidação pôde ser aplicado na funcionalização do derivado do colesterol 250, levando à formação do composto 251 em 68% de rendimento para três etapas (Esquema 54). 81 Hartwig e colaboradores puderam estender a metodologia para a sililação seletiva de ligações C-H em posição b a aminas alifáticas, catalisadas por irídio, utilizando a fenantrolina 253 como ligante, nas condições semelhantes às utilizadas no protocolo estabelecido no trabalho anterior (Esquema 55). 82 Os substratos utilizados 252 foram sililmetilaminas, as quais formam produtos cíclicos de cinco membros 254 que posteriormente puderam ser oxidadas para formar ligações C-O.…”

Section: Formação De Ligações C-siunclassified

Funcionalização De Ligações C—h Em Estágio Tardio Em Síntese Orgânica

Rocha¹,

Salmazo²,

Hayashi³

et al. 2023

Quim. Nova

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LATE-STAGE FUNCTIONALIZATION OF C—H BONDS IN ORGANIC SYNTHESIS. The development of new strategies for the functionalization of the historically inert C—H bond arises as an excellent way to create new carbon—carbon and carbon— heteroatom bonds. With increasingly chemo- and site-selective methods that enables the late-stage functionalization of C—H bonds, the modification of specific sites in natural products and pharmaceuticals without altering their scaffold emerges as a powerful means for the diversification of complex molecules. In this review, we will introduce concepts of late-stage modifications, the use of C—H bond functionalization to forge new carbon—carbon and carbon—heteroatom bonds using metal catalysis and photochemistry in simple examples and their applications in natural products and pharmaceuticals. The aim of the review is to update and display to the reader the contributions and implications of this methodology to organic synthesis.

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Colesterol e composição dos ácidos graxos nas dietas para humanos e na carcaça suína

Cited by 14 publications

References 28 publications

Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism

Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism

A potential synbiotic product improves the lipid profile of diabetic rats

Funcionalização De Ligações C—h Em Estágio Tardio Em Síntese Orgânica

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