Genetic power of a brazilian three-generation family with generalized aggressive periodontitis. II

Rapp, Gisela Estela; Pineda-Trujillo, Nicolás; McQuillin, Andrew; Tonetti, Maurizio S.

doi:10.1590/s0103-64402011000100012

Cited by 5 publications

(4 citation statements)

References 14 publications

(16 reference statements)

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“…Correlation between plaque formation and periodontal disease etiology was established with the understanding that plaque maturation is the trigger for the start of inflammatory processes (2), which leads to the destruction of periodontal tissues (9). Traditional scaling and root planning are essential procedures in periodontal therapy (10) and rely on mechanical removal of plaque, calculus, root-bound toxins and contaminated cementum (11).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans and Streptococcus sanguinis

et al. 2011

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New periodontal disease treatments are needed to prevent infection progression. Photodynamic therapy (PDT) is one of the greatest pledges for this purpose. It involves the use of light of specific wavelength to activate a nontoxic photosensitizing agent in the presence of oxygen for eradication of target cells, and can be used for photokilling of microorganisms. This study evaluated in vitro the photodynamic effect of 0.01% toluidine blue-O (TBO) in combination with an AlGaInP diode laser light source on Aggregatibacter actinomycetemcomitans (A.a.) and Streptococcus sanguinis (S.s.). Suspensions (2 mL) containing A.a. and S.s. at 1.5 x 108 CFU/mL concentration were prepared and divided into 3 groups: Control group (no treatment), Dye group (inoculum and TBO for 5 min) and Dye/Laser group (inoculum, TBO for 5 min and laser for 3 min). Next, a dilution for subsequent subculture in 20 mL of Trypic Soy Agar (A.a) and Brucella Agar (S.s.) in Petri dishes (Pourplate Method) was done. Incubation of A.a. in microaerophilia and S.s. in aerobiosis at 35oC for 48 h was performed for subsequent visual counting of CFU/mL. Data were analyzed by one-way ANOVA and Tukey's HSD test at 5% significance level. For both strains, the control group showed a significantly higher (p<0.05) bacterial growth (1.5 x 108 CFU/mL), while the Dye group presented no significant reduction (p>0.05) in the CFU counts. The Dye/Laser group presented a significant decrease in the CFU counts (p<0.05) compared with the Control group (61.53% for A.a. and 84.32% for S.s.). It may be concluded that PDT was effective in reducing the numbers of A.a. and S.s. in vitro.

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Section: Discussionmentioning

confidence: 99%

In Vitro Effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans and Streptococcus sanguinis

et al. 2011

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“…Familial aggregation studies carried out by Marazita and coworkers (168) suggest that early-onset, or aggressive, periodontitis is inherited as an autosomal-dominant trait in Black families. Also, Rapp et al (225) have shown familial aggregation of periodontal disease in three generations of Brazilian families. Genetic studies of families affected with aggressive periodontitis were reviewed by Meng and co-workers (174).…”

Section: Genetics Genetic Factors As Risk Factors For Periodontal Dismentioning

confidence: 98%

“…Also, Rapp et al. (225) have shown familial aggregation of periodontal disease in three generations of Brazilian families. Genetic studies of families affected with aggressive periodontitis were reviewed by Meng and co‐workers (174).…”

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confidence: 98%

Risk factors for periodontal disease

Genco¹,

Borgnakke²

2013

Periodontology 2000

854

722

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Risk factors play an important role in an individual's response to periodontal infection. Identification of these risk factors helps to target patients for prevention and treatment, with modification of risk factors critical to the control of periodontal disease. Shifts in our understanding of periodontal disease prevalence, and advances in scientific methodology and statistical analysis in the last few decades, have allowed identification of several major systemic risk factors for periodontal disease. The first change in our thinking was the understanding that periodontal disease is not universal, but that severe forms are found only in a portion of the adult population who show abnormal susceptibility. Analysis of risk factors and the ability to statistically adjust and stratify populations to eliminate the effects of confounding factors have allowed identification of independent risk factors. These independent but modifiable, risk factors for periodontal disease include lifestyle factors, such as smoking and alcohol consumption. They also include diseases and unhealthy conditions such as diabetes mellitus, obesity, metabolic syndrome, osteoporosis, and low dietary calcium and vitamin D. These risk factors are modifiable and their management is a major component of the contemporary care of many periodontal patients. Genetic factors also play a role in periodontal disease and allow one to target individuals for prevention and early detection. The role of genetic factors in aggressive periodontitis is clear. However, although genetic factors (i.e., specific genes) are strongly suspected to have an association with chronic adult periodontitis, there is as yet no clear evidence for this in the general population. It is important to pursue efforts to identify genetic factors associated with chronic periodontitis because such factors have potential in identifying patients who have a high susceptibility for development of this disease. Many of the systemic risk factors for periodontal disease, such as smoking, diabetes and obesity, and osteoporosis in postmenopausal women, are relatively common and can be expected to affect most patients with periodontal disease seen in clinics and dental practices. Hence, risk factor identification and management has become a key component of care for periodontal patients.

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“…In a different study conducted on the Chinese Han population, 233 individuals from 73 families were enrolled and autosomal recessive inheritance was suggested for the inheritance of AgP . Furthermore, in a different study involving a single family, which was ascertained through a 23‐year‐old female proband, family aggregation rate of AgP was reported to be high and autosomal dominant transmission was suggested as the pattern of inheritance …”

Section: Discussionmentioning

confidence: 99%