2010
DOI: 10.1590/s0103-64402010000400013
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Abstract: Despite the importance of clonality to understand the pathogenesis and progression of tumors, it has not been investigated yet in giant cell lesions of the jaws. The aim of this study was to analyze the clonality of peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) of the jaws. Six samples of PGCL and 5 samples of CGCL were analyzed in this study using the polymorphic human androgen receptor locus (HUMARA) assay. Three out of the 5 samples of the CGCL and 3 out of 6 samples of PGCL exh… Show more

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Cited by 6 publications
(3 citation statements)
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References 18 publications
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“…Central giant cell lesion (CGCL) likely represents a benign neoplasm [1], though its former designation, reparative giant cell granuloma, reflects the theory that it may be a reactive lesion. CGCLs are frequently discovered incidentally on routine dental radiography.…”
Section: Discussionmentioning
confidence: 99%
“…Central giant cell lesion (CGCL) likely represents a benign neoplasm [1], though its former designation, reparative giant cell granuloma, reflects the theory that it may be a reactive lesion. CGCLs are frequently discovered incidentally on routine dental radiography.…”
Section: Discussionmentioning
confidence: 99%
“…Among the odontogenic lesions, CGCL commonly manifest as loculated radiolucency in the anterior mandible of young females (Whitaker and Bouquot, 1994). They are characterized with the presence of multinucleated giant cell granuloma, mononuclear stromal cells with intra-osseous origin (Amaral et al, 2010). Biological…”
Section: Introductionmentioning
confidence: 99%
“…The lesion is predominantly found in young adults before the age of 30 years with a female preponderance. The anterior portion of the mandible is the most frequently affected region, commonly extending across the midline (4).…”
Section: Introductionmentioning
confidence: 99%