Oral lichen planus: a clinical and morphometric study of oral lesions in relation to clinical presentation

Seoane, Juan; Romero, M.; Varela‐Centelles, Pablo; Dios, Pedro Diz; García-Pola, María

doi:10.1590/s0103-64402004000100002

Cited by 44 publications

(34 citation statements)

References 16 publications

(23 reference statements)

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“…Krasowska ve ark. (20) OLP etyolojisinde rol aldığı düşünülen stres düzeyi, endokrin ve immun parametreler arasındaki ilişkiyi incelemişler; LP hastaları ve kontrol grubu arasında tecrübe edilen stres açısından anlamlı bir farklılık saptayamamakla birlikte yaptıkları klinik görüşmelerde hastaların %53'ünün stresin LP semptomlarını başlattığı ya da arttırdığını söylediklerini bildirmişlerdir. Ancak, kontrol grubu ile karşılaştırıldığında, LP (19)(20)(21), araştırmamızda da çalışma ve kontrol grubundaki hastaların kortizol düzeyleri arasında istatistiksel olarak anlamlı bir farklılık bulunmamıştır.…”

Section: Discussionunclassified

“…(20) OLP etyolojisinde rol aldığı düşünülen stres düzeyi, endokrin ve immun parametreler arasındaki ilişkiyi incelemişler; LP hastaları ve kontrol grubu arasında tecrübe edilen stres açısından anlamlı bir farklılık saptayamamakla birlikte yaptıkları klinik görüşmelerde hastaların %53'ünün stresin LP semptomlarını başlattığı ya da arttırdığını söylediklerini bildirmişlerdir. Ancak, kontrol grubu ile karşılaştırıldığında, LP (19)(20)(21), araştırmamızda da çalışma ve kontrol grubundaki hastaların kortizol düzeyleri arasında istatistiksel olarak anlamlı bir farklılık bulunmamıştır. Bu sonuçlar Chiapelli'nin (22) bu hastalık için ileri sürdüğü psikolojik bozuklukların kortizol düzeylerini yükselttiği ve daha agresif bir klinik OLP tablosuna neden olduğu şeklin-deki psikonöroendokrin interaksiyon modelini desteklememekle birlikte OLP' lu bireylerde süreklilik kaygı düzeyinin yüksek olması anksiyetenin bu hastalığın etyolojisinde önemli bir faktör olabileceğini ortaya koymaktadır.…”

Section: Discussionunclassified

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EVALUATION OF LEVELS OF CORTIZOL, ANXIETY and DEPRESSION in PATIENTS WITH ORAL LICHEN PLANUS (OLP)

Pekiner¹,

Borahan²,

Özbayrak³

2014

MUSBED

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Oral liken planus (OLP)'lu bireylerde kortizol, anksiyete ve depresyon düzeylerinin değerlendirilmesi Amaç: Bu çalışmanın amacı; oral liken planus'lu bireylerde kortizol ve anksiyete/ depresyon düzeylerini değerlendirmek ve psikolojik faktörlerin oral liken planus (OLP)'un etyolojisindeki etkilerini saptamaktır. Yöntem: Marmara Üniversitesi Dişhekimliği Fakültesi Oral Diagnoz ve Radyoloji Anabilim Dalı Kliniği'ne başvuran, OLP klinik ön tanısı konmuş 30 birey hasta grubunu, sağlıklı 30 birey ise kontrol grubunu oluşturmuştur. OLP ön tanılı bireylerden kliniğimizde biyopsi materyali alınarak tanı histopatolojik olarak da desteklenmiştir. Hem çalışma hem de kontrol grubunun periferik kan kortizol düzeyleri değerlendirilmiş ve "Spielberger Durumluluk Kaygı Testi (DKT) -Süreklilik Kaygı Testi (SKT)" ile "Zung Depresyon Ölçeği (ZDP)" uygulanmıştır. Bulgular: Çalışma ve kontrol grubundaki hastaların kortizol, DKT ve ZDP değerleri ortalaması arasında anlamlı bir farklılık bulunmazken (p>0.05), çalışma grubunun SKT değerleri ortalaması kontrol grubundan istatistiksel olarak anlamlı düzeyde yüksektir (p<0.05). Sonuç: Oral Liken Planus'lu bireylerde süreklilik kaygı düzeyinin yüksek olması anksiyetenin bu hastalığın etyolojisinde önemli bir faktör olabileceğini ortaya koymaktadır. Anahtar sözcükler: Oral Liken Planus, anksiyete, depresyon ABS TRACT Evaluation of levels of cortizol, anxiety and depression in patients with oral lichen planus (OLP)Objectives: The aim of this study is to evaluate the levels of cortizol and anxiety/depression in individuals with oral lichen planus and determine the effects of psychologic factors on the etiology of Oral Lichen Planus. Method: 30 individuals pre-diagnosed with OLP who referred to Marmara University, Dentistry Faculty, Department of Oral Diagnosis and Radiology constitute the patient group while 30 healty individuals are control group. Pre-diagnosis of OLP of the patients was supported histopathologically with biopsies taken. Peripheral blood cortizol levels were evaluated and Spielberger State-Trait Anxiety Test with Zung depression Scale (ZDS) were administrated on both study and control group. Results: There was no statistical differences on the mean levels of Trait Anxiety Test and ZDS between the study and conrol group (p>0.05), while mean levels of State Anxiety Test of the study group was significantly higher than the mean levels of mean levels of State Anxiety Test of control group (p<0.05). Conclusion: Higher levels of state anxiety in individuals with oral lichen planus exhibits that anxiety is an important factor on the etiology of this disease.

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Section: Discussionunclassified

EVALUATION OF LEVELS OF CORTIZOL, ANXIETY and DEPRESSION in PATIENTS WITH ORAL LICHEN PLANUS (OLP)

Pekiner¹,

Borahan²,

Özbayrak³

2014

MUSBED

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“…Lichen planus rarely confined to the tongue only without the involvement of other intraoral sites such as the buccal mucosa and the gingiva (24,25). The prevalence of ankyloglossia is between 0.1% and 3.7% in different studies (7,26).…”

Section: No Of Patientsmentioning

confidence: 99%

The prevalence of tongue lesions in Libyan adult patients

Byahatti¹,

Ingafou²

2010

J Clin Exp Dent

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This is the first ever-detailed study of tongue diseases in Libyan population, where the tongue conditions found in 320 patients (9.2%) of 3,460 consecutive patients screened in the department of Oral Medicine and Oral Diagnosis at faculty of dentistry, Benghazi Libya. Both sexes were affected almost equally and only 25 patients were aware of their tongue disease. Forty patients had one or more systemic illness, 34 of them was on regular medications. Fissured tongue was the most prevalent condition, as it has been found in 155(48.4%) patients, depapillated tongue in 82(25.6%) patients and geographic tongue in 55(17.2%) patients, other disease conditions were found in a lesser number of patients. Fifty-four patients had painful tongue conditions; other complaints included malodor, speech interferences or swallowing difficulties. Most conditions were confined to the tongue and in more than 90%, there had been involvement of the dorsum of the tongue. Fortunately, most tongue conditions can easily be diagnosed on clinical grounds by any experienced clinician, hence, the histopathological examination and other investigations are needed in only few cases. There is a wide variation in the prevalence of most of tongue diseases worldwide due to the lack of uniformity in criteria of the studies. Thus, more studies are needed in this regard.

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“…Therefore, it is possible that due to lack of variation in these risk factors, we were unable to determine the effects of smoking or alcohol abuse. It is important to note that evidence about the role smoking or alcohol abuse plays in the etiopathogenesis of lichen planus is inconsistent, with some studies not associating these risks with OLP (4,31), while other studies related smoking and alcohol abuse to a higher potential to develop dysplastic changes (23).…”

Section: Discussionmentioning

confidence: 99%

Oral lichen planus: a 4-year clinical follow-up study

Rimkevičius¹,

Aleksejūnienė²,

Pūrienė³

et al. 2017

Turk J Med Sci

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Background/aim: This study aimed to examine oral lichen planus (OLP) cases histopathologically and cytologically, describe different clinical aspects of OLP manifestations, and associate different OLP clinical forms with self-reported oral health and with local and systemic risk factors. Materials and methods:All patients with a referral diagnosis of OLP received biopsies. The histological evaluation assessed infiltration with lymphocytes, epithelial hyperplasia, and hyperkeratosis. Histology was used to validate the OLP diagnosis and to evaluate the malignant transformation of OLP lesions. Clinical manifestations of OLP and potential local oral environment-related risks were clinically assessed. Systemic risks were evaluated by a structured questionnaire.Results: A total of 133 patients with a histologically confirmed OLP diagnosis were followed. There were more females (N = 109) than males (N = 24) and the majority of patients were older than 50 years. The reticular form (45.1%) was the most prevalent clinical form followed by the erosive-ulcerative form (33.8%). The histological characteristics were most pronounced in the erosive-ulcerative form. Of the OLP cases, 2.3% had a malignant transformation. Conclusion:Reticular and erosive-ulcerative were the most prevalent OLP forms. There were more female than male OLP patients. Except for medication use, there were no statistically significant differences among different clinical OLP forms in either local or systemic risk factor distributions.

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Oral lichen planus: a clinical and morphometric study of oral lesions in relation to clinical presentation

Cited by 44 publications

References 16 publications

EVALUATION OF LEVELS OF CORTIZOL, ANXIETY and DEPRESSION in PATIENTS WITH ORAL LICHEN PLANUS (OLP)

EVALUATION OF LEVELS OF CORTIZOL, ANXIETY and DEPRESSION in PATIENTS WITH ORAL LICHEN PLANUS (OLP)

The prevalence of tongue lesions in Libyan adult patients

Oral lichen planus: a 4-year clinical follow-up study

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