Diretrizes para o manejo do tétano acidental em pacientes adultos

Auditoria clinica do tratamento primário de fraturas expostas: Tratamento antimicrobiano e profilaxia antitetânica

“…11 Recomenda apenas associação de metronidazol para pacientes com histórico de vacinação desconhecido ou incerto, devido à atividade antianaeróbica deste agente, o que reduz a carga bacteriana no foco da inoculação e evita a produção da toxina do tétano. 27 No entanto, a utilização do metronidazol não exclui a necessidade de imunoprofilaxia. Entretanto, no período auditado, não havia registro do histórico vacinal para a totalidade dos portadores de FE, o que foi considerado uma grave inadequação, tendo em vista as prováveis oportunidades perdidas de vacinação.…”

Trismo, opistótono e riso sardônico: quem se lembra dessa doença?

“…In this issue of RBTI we have a pioneering movement by the Brazilian Association of Intensive Medicine -AMIB that is publishing guidelines for the treatment of tetanus. (14) Organized by a panel of experts, these guidelines collect the best available evidences upon which to base medical practices and communicate them in the form of recommendations, thus proposing a sensible homogenization of conduct. These arise from hard, courageous work: the pertinent literature is vast and widely dispersed, distributed among hard-tofind publications, found in languages that are not the most common and involves local issues from countries that are still in development.…”

“…It should be noted, however, that the lack of precise evidence does not preclude from generating strong recommendations, as is seen in these proposed guidelines for the management of tetanus. (14) It is worth highlighting (and praising) the convenience (and propriety) of commissioning a panel of experts of diverse backgrounds and inflections, who are used to professionally dealing with the clinical patients of tetanus under different realities and traditions, with the task of drafting these guidelines. It was a comprehensive panel comprising southern, northeastern and other Brazilian regional accents as well as the tendencies and manias of both infectologists and intensive care physicians, which due to its testimonial nature could only produce guidelines that are appropriate to the Brazilian national reality.…”

“…I would also highlight the importance of multidisciplinarity in caring for tetanus patients as well as in the production and communication of knowledge, both in the publication by Santos et al, (11) whose authorship included a physical therapist, as well as in the guidelines, (14) that specifically cover physical therapy treatment as one of their recommendations. This is the second direction for the research lines I mentioned: interesting our colleagues from other health professions such as speech-language pathologists and nurses to produce knowledge on this subject.…”

Caracterização e avaliação da atividade enzimática da toxina tetânica submetida à radiação gama por Cobalto 60

“…lise celular através da formação de poros por hidrólise de fosfolipídios de membrana70 . O tecido sadio ao redor da ferida então é danificado e essa lesão contribui para a diminuição de oxigênio do local71 . Devido à oxidorredução na região, as condições para a multiplicação bacteriana são otimizadas, o que promove maior crescimento de microrganismos anaeróbicos72 .…”