2011
DOI: 10.1590/s0103-507x2011000300015
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Abstract: Malaria is one of the world's leading parasitic diseases and affects a considerably large number of people. Considering the epidemiological reach of Plasmodium falciparum, which is almost always responsible for the most severe cases of malaria, a discussion of the clinical features and therapeutic interventions is important. In the cases of patients with severe malaria, admission to an intensive care unit is mandatory to reduce complications. To have an impact on survival rates, treatment with antimalarial dru… Show more

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Cited by 61 publications
(29 citation statements)
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“…The swelling of the glomeruli and the increased thickness of the basement membrane have been described in other studies (7)(8)(9)(10) and attributed to the deposition of the malarial immune complexes (antigen, antibody and complement) (12,13) . It has been reported that the immune complex can be formed and localized in the glomeruli during human malaria (12)(13)(14)(15) resulting in the nephrotic syndrome (1,2) . The new and interesting observation as regards the pathological lesions in the kidneys is the evidence for degeneration of the proximal convoluted tubules (tubular nephrosis)…”
Section: Discussionmentioning
confidence: 57%
“…The swelling of the glomeruli and the increased thickness of the basement membrane have been described in other studies (7)(8)(9)(10) and attributed to the deposition of the malarial immune complexes (antigen, antibody and complement) (12,13) . It has been reported that the immune complex can be formed and localized in the glomeruli during human malaria (12)(13)(14)(15) resulting in the nephrotic syndrome (1,2) . The new and interesting observation as regards the pathological lesions in the kidneys is the evidence for degeneration of the proximal convoluted tubules (tubular nephrosis)…”
Section: Discussionmentioning
confidence: 57%
“…This clinical picture is pathophysiologically similar to bacterial sepsis, (3) which requires treatment in an intensive care unit (ICU) to avoid progression to death. (4) Transferring a patient with suspected severe malaria to the ICU allows the early detection and proper management of complications that might culminate in a fatal outcome. (5-7) …”
Section: Introductionmentioning
confidence: 99%
“…May this perspective also impact the generation of knowledge and its communication through publications and journals, which is not only appropriate and desirable, but even essential. In view of this, this edition of RBTI, containing the review article by Gomes et al, 'Severe Plasmodium falciparum malaria,' (2) is an extremely timely, if not pioneering effort, not only for covering a tropical disease that has a high epidemiologic impact in Brazil and around the world, but also, and foremost, for considering it as the severe sepsis it is. From their intensive care physician's perspective, the authors present this theme appropriately for intensive care specialists, infectiousintensive medicine specialists, and general physicians, who need to be equipped to deal with this disease, which is one of the greatest killers of the Brazilian and worldwide population of tropical region inhabitants, both in pre-intensive as well as intensive therapy contexts.…”
mentioning
confidence: 99%