Síndrome de Stevens-Johnson e necrólise epidérmica tóxica em medicina intensiva

Bulisani, Ana Carolina Pedigoni; Sanches, Giselle Domingues; Guimarães, Hélio Penna; Lópes, Renato D.; Vendrame, Letícia Sandre; Lopes, Antônio Carlos

doi:10.1590/s0103-507x2006000300012

Cited by 19 publications

(42 citation statements)

References 1 publication

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“…Em alguns estudos, a média identifi cada na categoria faixa etária foi de 27,1 anos com variação entre 08 e 62 anos, já em outros, a idade dos pacientes variou entre 9 e 76 anos (35 ± 23,04 anos). Para outros autores, a SSJ acomete pacientes de todas as idades, raças e sexo, e estão relacionadas, principalmente, ao uso de fármacos (EMERICK et al, 2014;RICARDO et al, 2009;FRANCA et al, 2009;BULISANI, 2006).…”

Section: Discussionunclassified

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Síndrome de Stevens-Johnson (SSJ) em adultos: revisão sistemática.

Ribeiro

Benito

2018

Univ. Ci. Saúde

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This is a systematic review (SR) which examined the issue of Stevens-Johnson syndrome (SJS) in adults. Electronic literature surveys were implemented in BVS®, LILACS®, MEDLINE®, SCIELO® and PubMed® databases. Eleven were elected (11) articles published in the historical period from 2007 to 2015, in Portuguese, Spanish and English, with the majority consisting of case studies. Patients described in articles, the average age of 39,42 being the youngest had 22 years and the oldest 61 years old, 53,85% (n=07) were female, 53,85% (n=07) developed SJS and 46,15% (n=06) progressed to Toxic Epidermal Necrolysis (TEN), 15,40% (n=02) had epilepsy or AIDS, 23,10% (n=03) consumed antibiotics, 92,30% (n=12) did not come to death. The study demonstrated the complexity and the potential of SJS, with almost half of those have evolved to NET. Therefore, it is of fundamental importance a greater awareness of society to mitigate the SSJ.

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Section: Discussionunclassified

“…Já na categoria sexo, dentre os casos analisados, 53,85% (n=07) se constituíram de pessoas do sexo feminino contra 46,15% (n=06) eram do sexo masculino, estando esse dado em concordância com a literatura científi ca corrente, que aponta que mulheres, mais frequentemente, desenvolvem essa enfermidade (FRANCA et al, 2009;BULISANI, 2006).…”

Section: Discussionunclassified

Síndrome de Stevens-Johnson (SSJ) em adultos: revisão sistemática.

Ribeiro

Benito

2018

Univ. Ci. Saúde

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“…[11][12][13]16,[18][19] O item J (capacitação profissional) engloba fatores correspondentes ao treinamento dos profissionais na realização do exame físico, da úlcera, do Índice Tornozelo Braço (ITB) e da terapia compressiva. Por fim, o item K (referência e contra-referência) destaca o resumo clínico, resultados de exames, diagnóstico, tratamento, conduta e outras observações relevantes.…”

Section: 17unclassified

Proposta de protocolo para assistência as pessoas com úlceras venosas

Dantas

Araújo

et al. 2014

Rev Enferm UFSM

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“…In Brazil, Stevens-Johnson syndrome varies from 1.2 to 6 cases per million people/year, and TEN varies from 0.4 to 1.2 million per year (Bulisani, 2006). For 2005 to 2007, the incidence rate of TEN in Japan was 0.28 to 0.52 per million per year (Kinoshita, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Although, SJS and TEN affect patients of all ages, races and genders, it is mainly related to the use of drugs (Bulisani, 2006). ADR"s cost to the health services is normally underestimated, as the majority of the reactions occur in patients who are not hospitalized, these reactions, therefore, is being under reported (Nagao-Dias et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Risk factors for, and treatment of, Stevens-Johnson syndrome and toxic epidermal necrolysis: Evidence from the literature

Silva¹,

Novaes²,

GÃ¶ttems³

et al. 2018

Afr. J. Pharm. Pharmacol.

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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are adverse drug reactions.They occur in the form of mild and sometimes severe cutaneous eruptions, with high morbidity and mortality, requiring fast and appropriate diagnosis and treatment. The aim of this study was to describe and discuss the evidence regarding the risk factors, complications and treatment of SJS and TEN in inpatients. The present study is a literature review of case reports published between January 1981 and December 2016, in the following databases: The Virtual Health Library (Biblioteca Virtual da Saúde -BVS), MEDLINE (National Library of Medicine, USA), LILACS (Latin American and Caribbean Health Sciences Literature), and PUBMED -NCBI (National Center for Biotechnology Information). A total of thirteen case reports were selected. Most of the cases (54%) developed adverse reactions to anticonvulsant drugs. The most common were valproic acid, lamotrigine and carbamazepine. In 69% of all cases, the patients were female. The patients' age range varied from 18 to 82 years old. In two cases which correspond to 15%, the patients were either infected with HIV or were receiving chemotherapy treatment for cancer. These patients had a higher possibility for immunosuppression. In relation to the actions taken as treatment, the suspension of the drugs or the treatment of the skin lesions occurred in 85 and 54% of the cases, respectively. A total of 6 cases, corresponding to 46%, occurred in the Latin American and Caribbean region. In conclusion, the use of anticonvulsants, and female gender, are among the main risk factors identified by the study. The main therapeutic action for SJS and TEN is the suspension of the use of the drug that triggered the inflammatory process and the topical treatment of the lesions caused.

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Síndrome de Stevens-Johnson e necrólise epidérmica tóxica em medicina intensiva

Cited by 19 publications

References 1 publication

Síndrome de Stevens-Johnson (SSJ) em adultos: revisão sistemática.

Síndrome de Stevens-Johnson (SSJ) em adultos: revisão sistemática.

Proposta de protocolo para assistência as pessoas com úlceras venosas

Risk factors for, and treatment of, Stevens-Johnson syndrome and toxic epidermal necrolysis: Evidence from the literature

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