8-O-4'-Neolignans from flower buds of Magnolia fargesii and their biological activities

Shen, Yanqiong; Liu, Yang; Shu, Lidang; Li, Gan‐Peng; Hu, Qiu‐Fen

doi:10.1590/s0103-50532012000700011

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…The Magnolia genus of herbs has been traditionally used to treat inflammatory diseases such as headache, sinusitis, and allergic rhinitis ( Gao et al, 2012 ). In particular, the dried flower buds of M. fargesii , or Xinyi, exhibit efficacy in treating airway inflammatory diseases including asthma, bronchitis, and emphysema ( Park et al, 2012 ; Oh et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Lignans Isolated From Flower Buds of Magnolia fargesii Attenuate Airway Inflammation Induced by Cigarette Smoke in vitro and in vivo

et al. 2018

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The flower buds of Magnolia fargesii, known traditionally as Xinyi, exert anti-inflammatory effects against inflammatory lung diseases such as COPD. Lignans isolated from Xinyi are an important group of plant-derived anti-inflammatory compounds. However, the mechanisms of action underlying their protective effects against COPD are not yet fully understood. Here, we showed that seven lignans (lignans 1–7) obtained from a CHCl3 fraction of Xinyi effectively suppress the inflammatory response in CSC-stimulated airway epithelial cells (in vitro) and in a mouse model of COPD established by exposure to CS and LPS. The CHCl3 fraction was found to inhibit CSC-induced IL-6 expression in human airway epithelial cells and to suppress the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the mouse model. Similarly, each of the seven lignans isolated from the CHCl3 fraction also suppressed the infiltration of inflammatory cells (neutrophils and macrophages) and secretion of inflammatory mediators such as reactive oxygen species (ROS), TNF-α, and IL-6 in vivo. Notably, all lignan compounds significantly suppressed both extracellular signal-related kinase (ERK) and Akt phosphorylation levels in CSC-stimulated human lung mucoepidermoid carcinoma (NCI-H292) cells. Of these, lignan 1 (dimethylpinoresinol) inhibited the expression of CSC-induced inflammatory cytokines (IL-1β, -6, and -8) in vitro in a dose-dependent manner by suppressing the activation of epidermal growth factor receptor (EGFR) and its downstream effectors, including ERK and Akt, in NCI-H292 cells. Our results show that the lignans isolated from Xinyi may prevent airway inflammatory diseases through the suppression of EGFR and its downstream effectors.

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Section: Introductionmentioning

confidence: 99%

Lignans Isolated From Flower Buds of Magnolia fargesii Attenuate Airway Inflammation Induced by Cigarette Smoke in vitro and in vivo

et al. 2018

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“…The S configuration at C-2' was assigned by a comparison of NMR and optical rotation data with those of stachylines A 10 , of which absolute configuration was established by the Mosher method. Since certain of the phenolic compounds exhibit potential cytotoxicity [15][16][17] . Compound 1 was tested for their cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) using the MTT method as reported previously 18 .…”

Section: Resultsmentioning

confidence: 99%

Antiviral Fluorenone Derivatives from Arundina gramnifolia

Niu¹,

Han²,

Kong³

et al. 2013

Asian J. Chem.

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“…The dried flower buds of Magnolia fargesii, with trivial name of Xinyi, has been used as herb medicine for the treatment of inflammatory-related diseases such as nasal congestion, empyema, sinusitis and allergic rhinitis 1,2 . Previous phytochemical investigations have reported that this species contains several secondary metabolites such as lignans [3][4][5] , neolignans 6,7 , sesquiterpenes 2,8 and essential oils 9 , which show various biological activities.…”

Section: Introductionmentioning

confidence: 99%

Neolignans from Flower Buds of Magnolia fargesii and their Antitobacco Mosaic Virus Activities

Yang¹,

Huang²,

Chen³

et al. 2013

Asian J. Chem.

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A new neolignan, fargesilignan A (1), together with five known neolignans (2-6), were isolated from the flower buds of Magnolia fargesii. The structures of 1-6 were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-6 were tested for their antitobacco mosaic virus activities. Compounds 2 and 5 (20 µM) showed moderate antitobacco mosaic virus activity with inhibition rates of 14.5 and 22.2 %.

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8-O-4'-Neolignans from flower buds of Magnolia fargesii and their biological activities

Cited by 6 publications

References 13 publications

Lignans Isolated From Flower Buds of Magnolia fargesii Attenuate Airway Inflammation Induced by Cigarette Smoke in vitro and in vivo

Lignans Isolated From Flower Buds of Magnolia fargesii Attenuate Airway Inflammation Induced by Cigarette Smoke in vitro and in vivo

Antiviral Fluorenone Derivatives from Arundina gramnifolia

Neolignans from Flower Buds of Magnolia fargesii and their Antitobacco Mosaic Virus Activities

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