2009
DOI: 10.1590/s0103-50532009000600009
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Abstract: Endopleura uchi (Huber) Cuatrec. é uma planta medicinal da Amazônia utilizada no tratamento de inflamações e doenças do aparelho reprodutor feminino. A bergenina pura foi isolada do extrato metanólico das cascas de E. uchi, inicialmente por um processo de partição líquido-líquido, seguido de cromatografia em coluna de permeação em gel Sephadex LH-20 e finalmente de adsorção utilizando sílica gel 60. A elucidação estrutural foi determinada pela análise dos espectros de RMN. A atividade anti-inflamatória in vitr… Show more

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Cited by 66 publications
(53 citation statements)
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References 16 publications
(18 reference statements)
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“…Shi et al [36] and Wang et al [37] developed and reported the methods for determination and pharmacokinetic study of bergenin in biological fluid i.e. rat plasma by RP-HPLC method and Nunomura et al [38] also reported the determination of bergenin by RP-HPLC method. HPLC determination of bergenin in different Bergenia species was also done by Singh et al [39].…”
mentioning
confidence: 99%
“…Shi et al [36] and Wang et al [37] developed and reported the methods for determination and pharmacokinetic study of bergenin in biological fluid i.e. rat plasma by RP-HPLC method and Nunomura et al [38] also reported the determination of bergenin by RP-HPLC method. HPLC determination of bergenin in different Bergenia species was also done by Singh et al [39].…”
mentioning
confidence: 99%
“…Table 1 summarised the 1 H and 13 C NMR data for ML1 in comparison with the literature data. Based on the spectral data and comparison with literature [7] and [8], ML1 was determined to be a bergenin.…”
Section: Results and Discussion Structural Elucidation Of Isolated Comentioning
confidence: 98%
“…E. uchi is widely used by the people to combat myoma and arthritis, although only few biological studies are available on the properties of its extract. Bergenin (1) is a C-glucoside of 4-O-methyl gallic acid that has been isolated as the major component from the cortex of E. uchi and is used for treating gastrointestinal diseases such as gastritis, gastric ulcer, diarrhea, and constipation (Okada et al, 1973;Abe et al, 1980). In addition, studies report that bergenin reveals anti-inflammatory (Swarnalakshmi et al, 1984;Nunomura et al, 2009), antiarthritic (Nazir et al, 2007) and hypolipidemic effects (Jahromi et al, 1992).…”
Section: Introductionmentioning
confidence: 99%