A new bianthron glycoside as inhibitor of Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase activity

Macedo, Edângelo Moura Siqueira; Wiggers, Helton José; Silva, Maria Goretti de Vasconcelos; Braz‐Filho, Raimundo; Andricopulo, Adriano D.; Montanari, Carlos Alberto

doi:10.1590/s0103-50532009000500021

Cited by 8 publications

(5 citation statements)

References 16 publications

(15 reference statements)

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“…In 2009 we identified more than 400 articles after searching Web of Science, PubMed, SciDir and OVID databases using ‘isothermal AND titration AND calorimetry’ or ITC or ‘Isothermal Titration Calorimetry’ search terms. These have been classified into the following categories: Pre‐2009 references cited in the text and review articles 1–43 Protein‐protein and protein‐peptide interactions 44–124 Protein/peptide‐small molecule interactions 125–218 Protein/peptide‐metal ion interactions 219–253 Protein/peptide‐nucleic acid interactions 254–273 Protein/peptide‐lipid interactions 274–292 Protein/peptide‐polysaccharide interactions 293–316 Nucleic acid‐small molecule interactions 317–348 Small molecule interactions …”

Section: Introductionmentioning

confidence: 99%

Survey of the year 2009: applications of isothermal titration calorimetry

Falconer

Collins

2010

J. Mol. Recognit.

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Isothermal titration calorimetry (ITC) is now an established and invaluable method for determining the thermodynamic constants, association constant and stoichiometry of molecular interactions in aqueous solutions. The technique has become widely used by biochemists to study protein interaction with other proteins, small molecules, metal ions, lipids, nucleic acids and carbohydrates; and nucleic acid interaction with small molecules. The drug discovery industry has utilized this approach to measure protein (or nucleic acid) interaction with drug candidates. ITC has been used to screen candidates, guide the design of potential drugs and validate the modelling used in structure-based drug design. Emerging disciplines including nanotechnology and drug delivery could benefit greatly from ITC in enhancing their understanding and control of nano-particle assembly, and drug binding and controlled release.

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Section: Introductionmentioning

confidence: 99%

Survey of the year 2009: applications of isothermal titration calorimetry

Falconer

Collins

2010

J. Mol. Recognit.

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“…It is a shrub plant with a large canopy and rapid growth, reaching a height of 1.5 to 4 meters. Although it is morphologically similar to other species of the same genus, its inflorescences and fruits are more abundant and exuberant (MACEDO et al, 2009). It has a racemic axial inflorescence with yellow flowers (CMYK 0-0-100-0) of the standard type, where its developed bracts protect the obovate bud.…”

Section: Resultsmentioning

confidence: 99%

“…AndradeLima (1989) cites that several species of the genus Senna, including S. martiana are cultivated as ornamental. However, even with its remarkable ornamental potential, research on S. martiana is still more focused on its chemical components of pharmaceutical interest (MACEDO et al, 2009;MACEDO et al, 2016). The scores obtained by each species evaluated for the features of ornamental interest, as well the total score, are described in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Innovation in floriculture with ornamental plants from Caatinga biome

Beckmann-Cavalcante

Sabino

Barbosa

et al. 2017

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The Caatinga biome which presents a singular vegetation found only in Brazil has a diversity of vegetal species with uses not yet explored. In this sense, the objective was to study two species of the Caatinga biome to be used as cut flowers. The work was developed at the Agricultural Sciences Campus of the Federal University of the São Francisco Valley, Petrolina, PE. Based on previous studies, two endemic species of the Caatinga biome were selected: Neoglaziovia variegata and Senna martiana. The evaluation criteria were based on the length, stiffness and appearance of the stems; form of flower, fruit or leaf; income in floral composition; color or brightness; scent; originality; and real life in water and floral foam. For these characteristics grades were assigned (0, 5 and 10) and after classified for ornamental potential (high, medium, low and minimum ornamental potential). The results showed that the species N. variegata and S. martiana reached 80 and 85 points, respectively, classifying them as high ornamental potentiality. As such, they can be used as cut flower. Keywords: Neoglaziovia variegata, Senna martiana, floral art, floriculture, semiarid. RESUMOInovação na floricultura com plantas ornamentais do Bioma Caatinga O Bioma Caatinga, que apresenta uma vegetação singular, encontrada apenas no Brasil, possui diversidade de espécies vegetais com usos ainda não explorados. Nesse sentido, objetivou-se estudar espécies da flora da Caatinga para serem utilizadas como flores de corte. O trabalho foi desenvolvido no Campus de Ciências Agrárias da Universidade Federal do Vale do São Francisco, Petrolina, PE. Baseado em estudos prévios foram selecionadas duas espécies endêmicas do Bioma Caatinga: Neoglaziovia variegata e Senna martiana. Os critérios de avaliação foram baseados no comprimento, rigidez e aparência das hastes; forma da flor, fruto ou folha; rendimento na composição floral; cor ou brilho; aroma; originalidade; e, vida útil real na água e espuma floral. Para estas características foram atribuídas notas (0, 5 e 10) e, posteriomente, classificadas quanto ao potencial ornamental (alta, média, baixa e mínima potencialidade ornamental). Pelos resultados obtidos, a espécie N. variegata e S. martiana obtiveram 80 e 85 pontos respectivamente, classificando-as como de alta potencialidade ornamental. Sendo assim, podem ser utilizadas como flor de corte. Palavras-chave: Neoglaziovia variegata, Senna martiana, arte floral, floricultura, semiárido.

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“…Messana et al quinquangulin-6-O-β-D-glucopyranoside and chrysophanol dimethyl ether, chrysophanol, physcion, cis-3,3 ′ ,5,5 ′ -tetrahydroxy-4-methoxystilbene, trans-3,3 ′ ,5,5 ′ -tetrahydroxy-4-methoxystilbene, and cassiaside B from the root methanolic extracts [96]. de Macedo et al [97] reported the presence of bianthrone glycoside, namely, martianine 1 (10,10 ′ -il-chrysophanol-10-oxi-10,10 ′ -bi-glucosyl) from the stalks of Senna martiana (Benth.) H.S.Irwin & Barneby.…”

Section: Senna Speciesmentioning

confidence: 99%

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Alshehri

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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The use of phytochemicals is gaining interest for the treatment of metabolic syndromes over the synthetic formulation of drugs. Senna is evolving as one of the important plants which have been vastly studied for its beneficial effects. Various parts of Senna species including the root, stem, leaves, and flower are found rich in numerous phytochemicals. In vitro, in vivo, and clinical experiments established that extracts from Senna plants have diverse beneficial effects by acting as a strong antioxidant and antimicrobial agent. In this review, Senna genus is comprehensively discussed in terms of its botanical characteristics, traditional use, geographic presence, and phytochemical profile. The bioactive compound richness contributes to the biological activity of Senna plant extracts. The review emphasizes on the in vivo and in vitro antioxidant and anti-infectious properties of the Senna plant. Preclinical studies confirmed the beneficial effects of the Senna plant extracts and its bioactive components in regard to the health-promoting activities. The safety, side effects, and therapeutic limitations of the Senna plant are also discussed in this review. Additional research is necessary to utilize the phenolic compounds towards its use as an alternative to pharmacological treatments and even as an ingredient in functional foods.

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A new bianthron glycoside as inhibitor of Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase activity

Cited by 8 publications

References 16 publications

Survey of the year 2009: applications of isothermal titration calorimetry

Survey of the year 2009: applications of isothermal titration calorimetry

Innovation in floriculture with ornamental plants from Caatinga biome

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

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