Antiparasitic activities of acridone alkaloids from Swinglea glutinosa (Bl.) Merr.

Phytochemistry and quantification of polyphenols in extracts of the Asteraceae weeds from Diamantina, Minas Gerais state, Brazil

“…Eleven alkaloids isolated from Swingle glutinosa (Rutaceae) showed antiparasitic activity in strains of Plasmodium falciparum (Haemosporida: Plasmodidae), Trypanosome brucei rhodesiense (Trypanosomatida: Trypanosomae) and Leishmania donovani (Trypanosomatida: Trypanosomae) (Santos et al, 2009). …”

Natural Products as Cathepsin Inhibitors

“…Thus, it may become a valuable drug target for oncology. In total, 11 acridone alkaloids were isolated from the methanol extract of the stem bark of Swinglea glutinosa [83] and tested against recombinant human cathepsin V (Table 6.2). They described the biological evaluation and type of inhibition studies for a series of acridone alkaloids as potent inhibitors of cathepsin V. Molecular modeling and preliminary SAR studies were also performed to investigate the molecular basis underlying the binding affinity and inhibitory potency of this series of naturally occurring compounds.…”

Synthesis, cytotoxicity evaluation, and molecular modeling studies of 2,N10-substituted acridones as DNA-intercalating agents

“…Hence, acridone-based compounds are regarded to have chemotherapeutic potential. Numerous naturally occurring acridone alkaloids have been isolated and studied for their biological activities, including antiproliferative, 5–7 antiviral, 8,9 and antiparasitic 10 activities. Some well-recognized naturally occurring cytotoxic acridone-based compounds include acronycine and glyfoline (Figure 3).…”