Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

Oliveira, Rita de Cássia Silva de; Brito, Marcus Vinicius Henriques; Júnior, Rubens Fernando Gonçalves Ribeiro; Oliveira, Leonam Oliver Durval; Monteiro, Andrew Moraes; Brandão, Fernando Mateus Viégas; Cavalcante, Lainy Carollyne da Costa; Gouveia, Eduardo Henrique Herbster; Henriques, Higor Yuri Bezerra

doi:10.1590/s0102-865020170030000007

Cited by 16 publications

(16 citation statements)

References 19 publications

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“…Other researchers also proved that RIC was able to reduce the oxidative stress under I/R injury. Oliveira et al studied RIC in the kidney model in rats to further understand the role of MDA ( 107 ). Their studies showed similar results in which RIC was able to reduce the level of MDA and further attenuate I/R injury ( 107 ).…”

Section: Mechanisms Of Limb Remote Ischemic Pre- Per- and Postcondimentioning

confidence: 99%

“…Oliveira et al studied RIC in the kidney model in rats to further understand the role of MDA ( 107 ). Their studies showed similar results in which RIC was able to reduce the level of MDA and further attenuate I/R injury ( 107 ). Silva et al studied the relationship between RIC and antioxidant activity in rats, and their experiment consisted of three cycles of 5-min left hind limb ischemia followed by 5-min perfusion ( 77 ).…”

Section: Mechanisms Of Limb Remote Ischemic Pre- Per- and Postcondimentioning

confidence: 99%

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Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

et al. 2018

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Novel and innovative approaches are essential in developing new treatments and improving clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a series of mechanical interruptions in blood flow of a distal organ, following end organ reperfusion, shown to significantly reduce infarct size through inhibition of oxidation and inflammation. Ischemia/reperfusion (I/R) is what ultimately leads to the irreversible brain damage and clinical picture seen in stroke patients. There have been several reports and reviews about the potential of RIC in acute ischemic stroke; however, the focus here is a comprehensive look at the differences in the three types of RIC (remote pre-, per-, and postconditioning). There are some limited uses of preconditioning in acute ischemic stroke due to the unpredictability of the ischemic event; however, it does provide the identification of biomarkers for clinical studies. Remote limb per- and postconditioning offer a more promising treatment during patient care as they can be harnessed during or after the initial ischemic insult. Though further research is needed, it is imperative to discuss the importance of preclinical data in understanding the methods and mechanisms involved in RIC. This understanding will facilitate translation to a clinically feasible paradigm for use in the hospital setting.

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Section: Mechanisms Of Limb Remote Ischemic Pre- Per- and Postcondimentioning

confidence: 99%

Section: Mechanisms Of Limb Remote Ischemic Pre- Per- and Postcondimentioning

confidence: 99%

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

et al. 2018

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“…Ischemic conditioning is an adaptive endogenous protection, in which sublethal ischemia provides protection to organs or tissues from subsequent full insults (Dirnagl et al, 2009). The conditioning effect on ischemia-reperfusion injury also occurs remotely, and preclinical and clinical studies show that it protects multiple organs, including the brain, heart, and kidney (Zhou et al, 2011;Hoda et al, 2014;England et al, 2017;Oliveira et al, 2017). Ischemic conditioning applied before (pre), during (per), or after (post) insults elicits tolerance across these paradigms.…”

Section: Introductionmentioning

confidence: 99%

Remote Postischemic Conditioning Promotes Stroke Recovery by Shifting Circulating Monocytes to CCR2⁺Proinflammatory Subset

et al. 2019

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Brain injury from stroke is typically considered an event exclusive to the CNS, but injury progression and repair processes are profoundly influenced by peripheral immunity. Stroke stimulates an acute inflammatory response that results in a massive infiltration of peripheral immune cells into the ischemic area. While these cells contribute to the development of brain injury, their recruitment has been considered as a key step for tissue repair. The paradoxical role of inflammatory monocytes in stroke raises the possibility that the manipulation of peripheral immune cells before infiltration into the brain could influence stroke outcome. One such manipulation is remote ischemic limb conditioning (RLC), which triggers an endogenous tolerance mechanism. We observed that mice subjected to poststroke RLC shifted circulating monocytes to a CCR2 ϩ proinflammatory monocyte subset and had reduced acute brain injury, swelling, and improved motor/gait function in chronic stroke. The RLC benefits were observed regardless of injury severity, with a greater shift to a CCR2 ϩ subset in severe stroke. Adoptive transfer of CCR2-deficient monocytes abolished RLC-mediated protection. The study demonstrates the importance of RLC-induced shift of monocytes to a CCR2 ϩ proinflammatory subset in attenuating acute injury and promoting functional recovery in chronic stroke. The defined immune-mediated mechanism underlying RLC benefits allows for an evidence-based framework for the development of immune-based therapeutic strategies for stroke patients.

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“…An increasing number of researchers have explored the association between RIC and anti-oxidative activity, suggesting that limb RIC could markedly attenuate IRI through downregulating the expression of free radicals while upregulating the expression of antioxidant proteins. For instance, the level of malondialdehyde (MDA), which is frequently used as an indicator to assess the extent of oxidative stress, was significantly reduced following the application of RIC in combination with or without local IC in different animal models, such as cerebral, myocardial, hepatic and renal ischemic models [ 125 – 128 ]. In addition, RIC showed early promise as a protective approach during primary PCI in STEMI patients to enhance the antioxidant potential (increased levels of glutathione peroxidase, superoxide dismutase and total antioxidant capacity) and suppress the increased MDA level [ 129 ].…”

Section: Resultsmentioning

confidence: 99%

Remote ischemic conditioning: a promising therapeutic intervention for multi-organ protection

Zhou

Ding

et al. 2018

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Despite decades of formidable exploration, multi-organ ischemia-reperfusion injury (IRI) encountered, particularly amongst elderly patients with clinical scenarios, such as age-related arteriosclerotic vascular disease, heart surgery and organ transplantation, is still an unsettled conundrum that besets clinicians. Remote ischemic conditioning (RIC), delivered via transient, repetitive noninvasive IR interventions to distant organs or tissues, is regarded as an innovative approach against IRI. Based on the available evidence, RIC holds the potential of affording protection to multiple organs or tissues, which include not only the heart and brain, but also others that are likely susceptible to IRI, such as the kidney, lung, liver and skin. Neuronal and humoral signaling pathways appear to play requisite roles in the mechanisms of RIC-related beneficial effects, and these pathways also display inseparable interactions with each other. So far, several hurdles lying ahead of clinical translation that remain to be settled, such as establishment of biomarkers, modification of RIC regimen, and deep understanding of underlying minutiae through which RIC exerts its powerful function. As this approach has garnered an increasing interest, herein, we aim to encapsulate an overview of the basic concept and postulated protective mechanisms of RIC, highlight the main findings from proof-of-concept clinical studies in various clinical scenarios, and also to discuss potential obstacles that remain to be conquered. More well designed and comprehensive experimental work or clinical trials are warranted in future research to confirm whether RIC could be utilized as a non-invasive, inexpensive and efficient adjunct therapeutic intervention method for multi-organ protection.

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Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

Abstract: Remote ischemic perconditioning was more effective reducing renal ischemia-reperfusion injury than administration of tramadol or association of both treatments.

Cited by 16 publications

References 19 publications

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

Remote Postischemic Conditioning Promotes Stroke Recovery by Shifting Circulating Monocytes to CCR2⁺Proinflammatory Subset

Remote ischemic conditioning: a promising therapeutic intervention for multi-organ protection

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Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

Abstract: Remote ischemic perconditioning was more effective reducing renal ischemia-reperfusion injury than administration of tramadol or association of both treatments.

Cited by 16 publications

References 19 publications

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

Remote Postischemic Conditioning Promotes Stroke Recovery by Shifting Circulating Monocytes to CCR2+Proinflammatory Subset

Remote ischemic conditioning: a promising therapeutic intervention for multi-organ protection

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Remote Postischemic Conditioning Promotes Stroke Recovery by Shifting Circulating Monocytes to CCR2⁺Proinflammatory Subset