Anatomo-radiological correlation using 18-FDG-PET in abdominal sepsis model in rats. A preliminary study

Azevedo, Ítalo Medeiros; Carvalho, Marília Daniela Ferreira; Nascimento, Rafael Pereira; Macedo, Robson; Aquino, Mônica Raquel de Souza; Medeiros, Aldo Cunha

doi:10.1590/s0102-865020170030000001

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“…In fact, the septic animals in the present study were clinically dehydrated and with weight loss 24 hours after sepsis induction. In this study the CLP sepsis model was used, following the technique of previous experimental reports 17,18 .…”

Section: ■ Discussionmentioning

confidence: 99%

Diagnostic accuracy of 18F-FDG-PET in abdominal sepsis in rats

et al. 2020

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The objective of this study was to investigate the accuracy of 18F-FDG-PET in the diagnosis of multibacterial abdominal sepsis by cecum ligation and puncture (CLP) in rats. Methods: Adult Wistar rats (Rattus norvegicus), weighing 227±35g, were allocated into a sepsis group by CLP (n=10) and sham group (n=10). 18F-FDG-PET using microPET was performed on all rats after 24 hours. Results: All animals survived for postoperative 24h. The abdomen/liver ratio of the standardized uptake value (SUV) percentage was significantly higher in the sepsis group than in the sham (p=0.004). The ROC curve showed an accuracy of 18F-FDG-PET to detect abdominal sepsis of 88.9% (p=0.001), sensitivity of 90% and specificity of 88.9%. When a cutoff point of 79% of the ratio between the SUV on the abdominal region and liver was established, the sensitivity was 90%, specificity of 88.9%; positive and negative predictive values of 90.0% and 88.9%, respectively. Conclusions: The diagnostic accuracy of 18F-FDG-PET in rats with abdominal sepsis was significantly high. It was also demonstrated the predictive ability of the abdomen/liver SUV ratio to diagnose abdominal sepsis. These findings may have implications for the clinical setting, locating septic foci with PETscan.

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Section: ■ Discussionmentioning

confidence: 99%