Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats

Qin, Zhigang; Li, Guijie; Liu, Naijie; Zhao, Hang

doi:10.1590/s0102-865020160100000004

Cited by 2 publications

(1 citation statement)

References 18 publications

(18 reference statements)

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“…In the same experimental model, the reduction in the incidence of IA rupture produced by treatment with the ER modulator bazedoxifene is associated with a significant decrease of MMP-9 expression that, on the contrary, was upregulated by ovariectomy ( 53 ). Estradiol administration has been also shown to inhibit the formation of lipid peroxidation products and restore middle cerebral arterial viscoelasticity and compliance in aged female rats ( 86 , 87 ). In a rabbit model of IA induced by carotid ligation, estrogen deficiency, in combination with hypertension, increases vessel length and tortuosity in the circle of Willis, probably by lowering the tolerance of vascular tissue to hemodynamic stresses caused by carotid ligation, making it more vulnerable to flow-induced aneurysmal remodeling ( 88 ).…”

Section: Molecular Mechanisms Of Estrogen Protection To Ia Formationmentioning

confidence: 99%

Why Are Women Predisposed to Intracranial Aneurysm?

Fréneau

Baron-Menguy

Vion

et al. 2022

Front. Cardiovasc. Med.

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Intracranial aneurysm (IA) is a frequent and generally asymptomatic cerebrovascular abnormality characterized as a localized dilation and wall thinning of intracranial arteries that preferentially arises at the arterial bifurcations of the circle of Willis. The devastating complication of IA is its rupture, which results in subarachnoid hemorrhage that can lead to severe disability and death. IA affects about 3% of the general population with an average age for detection of rupture around 50 years. IAs, whether ruptured or unruptured, are more common in women than in men by about 60% overall, and more especially after the menopause where the risk is double-compared to men. Although these data support a protective role of estrogen, differences in the location and number of IAs observed in women and men under the age of 50 suggest that other underlying mechanisms participate to the greater IA prevalence in women. The aim of this review is to provide a comprehensive overview of the current data from both clinical and basic research and a synthesis of the proposed mechanisms that may explain why women are more prone to develop IA.

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Section: Molecular Mechanisms Of Estrogen Protection To Ia Formationmentioning

confidence: 99%

Why Are Women Predisposed to Intracranial Aneurysm?

Fréneau

Baron-Menguy

Vion

et al. 2022

Front. Cardiovasc. Med.

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The vascular protective role of oestradiol: a focus on postmenopausal oestradiol deficiency and aneurysmal subarachnoid haemorrhage

et al. 2019

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The steroid hormone, oestradiol, has pleiotropic functions. The protective effects of oestradiol are attributed to its anti-inflammatory, antioxidant, anti-atherogenic, anti-apoptotic, vasodilatory activities and regulation of micro RNA. Oestradiol upregulates endothelial nitric oxide synthase gene expression and increases the production of nitric oxide, an important vasodilator. It suppresses the renin-angiotensin system and monitors haemodynamic stress. The hormone maintains the integrity of blood vessels by reducing oxidative stress while upregulating the expression of antioxidant enzymes and prevents vascular inflammation by regulating pro-and anti-inflammatory cytokines. Aneurysmal subarachnoid haemorrhage (aSAH) occurring as a consequence of the rupture of an intracranial aneurysm is a devastating cerebrovascular event, representing 5-7% of all strokes. Postmenopausal women are more susceptible to aSAH compared to men in the same age group. This gender disparity has been attributed to reduced levels of the vascular protective hormone oestradiol following menopause. This review is focused on the protective role of oestradiol on vasculature and how the drop in oestradiol levels after menopause dramatically increases the incidence of aSAH in women. During menopause, oestradiol deficiency may affect vascular integrity causing dysregulation of vascular homeostasis by affecting the renin-angiotensin-aldosterone system (RAAS) and inflammatory and apoptotic cascades, resulting in the weakening of the cerebral arterial wall and potentially to development of an aneurysm and its rupture. In view of the role of oestradiol in maintaining vascular integrity, treatments involving hormone replacement could be a promising approach in postmenopausal women who are at risk of developing or rupturing an intracranial aneurysm.

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Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats

Cited by 2 publications

References 18 publications

Why Are Women Predisposed to Intracranial Aneurysm?

Why Are Women Predisposed to Intracranial Aneurysm?

The vascular protective role of oestradiol: a focus on postmenopausal oestradiol deficiency and aneurysmal subarachnoid haemorrhage

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