L-carnitine has a protective effect on the colonic mucosa during abdominopelvic radiotherapy in rats

Taş, Şükrü; Özkan, Ömer Faruk; Çıkman, Öztekin; Kiraz, Aslı Öztürk; Akgün, Yılmaz; Karaayvaz, Muammer

doi:10.1590/s0102-865020160090000007

Cited by 5 publications

(6 citation statements)

References 29 publications

(27 reference statements)

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“…Also Akpolate and his colleagues (14) reported that ibuprofen and L-carnitine after oral administration had a protective effect by decreasing the severity of radiotherapy-induced duodenal mucosal injury in histopathological evaluation. L-carnitine significantly reduced the radiation induced histopathological damage caused to the colonic mucosa in rats and had a preventive effect on radiation colitis as reported by (Tas et al) (15) .…”

Section: Resultssupporting

confidence: 67%

“…Radiation-related acute/chronic colitis induced by the cytotoxic effect of the ionizing radiation on the intestinal mucosa by increasing the levels of free oxygen radicals, antioxidant drugs as L-carnitine and vitamin E prevent free oxygen radical formation, no peroxidative stress effect on the cell and protect against radiation-induced colitis (4) . Radiation-related liver damage observed in 5-10% of patients post radiation exposure by a dose exceeding 30 Gy (5) .…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of L-carnitine and vitamin E on gastrointestinal tract organs on male rats post radiation exposure

Fouly

Ali

2021

Int J Radiat Res

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Background:Although ionizing radiation is a risk factor, it is a therapeutic agent for cancer. Objectives: The protective and defensive effect of L-Carnitine and vitamin E on gastrointestinal tract organs (liver, spleen and intestine) post whole body gamma irradiation exposure. Material and methods: 56 male albino rats, which were divided into four groups (14 rats per group); group (I): Control group, group (II): rats were irradiated with a single dose of whole body gamma rays (6 Gy) and left 4 weeks. Group (III): rats were given L-Carnitine for five days, then irradiated by same dose. Group (IV): rats were received L-Carnitine and vitamin E for five days then irradiated by same dose. At 1 and 4 weeks post radiation exposure, seven rats from each group were scarified, blood and GIT tissue samples were collected. Results: Liver and blood samples: radiation related degenerative damage was obviously higher in the radiation group than the control group with elevated liver enzymes, however pretreatment groups revealed reduced radiation induced acute liver damage compared to the radiation group with significant improvement in liver enzymes. Spleen and intestinal samples: radiation induced damage were significantly higher in the radiation group versus the control group, however, in pre-treatment groups no significant improvement in radiation induced effects were noted compared with radiation group. Conclusion: A great radio protective effect of both L-carnitine and vitamin E after radiation exposure mainly in liver tissue and its enzymes but not in both spleen and intestinal tissue.

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Section: Resultssupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Protective effect of L-carnitine and vitamin E on gastrointestinal tract organs on male rats post radiation exposure

Fouly

Ali

2021

Int J Radiat Res

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“…The predicted enhancement of the 'TnF-α nF-κB Signaling Pathway' suggests radiation-induced enteritis (Table ii). recently, radioprotective agents, such as α-lipoic acid and l-carnitine, have been studied, which alleviate radiation-induced enteritis as a side effect during radiotherapy (34,35). understanding the underlying molecular mechanisms may lead to the development of novel effective radioprotective agents.…”

Section: Discussionmentioning

confidence: 99%

Changes in miRNA expressions in the injured small intestine of mice following high‑dose radiation exposure

et al. 2020

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The small intestine is one of the most highly regenerative and radiosensitive tissues in mammals, including humans. exposure to high doses of ionizing radiation causes serious intestinal damage. recently, several investigations have been conducted using radioprotective agents to determine ways for reducing intestinal damage caused by radiation exposure. However, a thorough understanding of functional changes occurring in the small intestine of mice exposed to high-dose radiation is necessary for developing novel and more potent radioprotective agents. in this study, we examined changes in microrna (mirna/mir) expressions in the small intestine of mice at 72 h after X-ray exposure (10 Gy). We identified seven upregulated mirnas and six downregulated mirnas in the small intestine of mice following radiation exposure using mirna microarray analysis. Particularly, mir-34a-5p was highly expressed, which was confirmed by reverse transcription-quantitative Pcr. Forkhead box P1 (Foxp1) was predicted to be a target of the mrna of mir-34a-5p using omicsnet. decreased Foxp1 expression in the small intestine following radiation exposure was confirmed, suggesting that Foxp1 expression recovery may induce the suppression of radiation-induced enteritis. Therefore, mir-34a-5p is a potential target molecule for developing novel radioprotective agents.

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“…For the analyzed period, the total cost of one package of the levocarnitine preparations in USD fell by 26%: By 21% for oral solutions and 32% for drugs for injections, which is mainly due to significant currency exchange rate fluctuations during 2015 [ Figure 5]. Consequently, the Statistical Data Suggest that there is a Growing Market Demand for Levocarnitine for Oral Administration [13,14] A similar analysis was carried out on the development of the market for glucosamine hydrochloride monoforms during 2015-2017 presented as a powder for oral solution preparation of 1.5 g glucosamine hydrochloride in a sachet of four manufacturers and glucosamine hydrochloride solution 200 mg/ml in 2 ml ampoules of two manufacturers.…”

Section: Discussionmentioning

confidence: 99%

Marketing Analysis of Levocarnitine and Glucosamine Preparations

Voronkina¹

2018

IJGP

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Aim: For the problem of the struggle of the human body with extreme strains, it is advisable to use active pharmaceutical ingredients that would directly participate in the metabolism having an actoprotective effect without exhausting the body. Levocarnitine and glucosamine have such properties. In this work was studied the development of the pharmaceutical market of Ukraine and the definition of market needs for combined and monopreparations of levocarnitine and glucosamine. Materials and Methods: The analysis of the market from January 2015 to September 2017 showed a significant increase in the sales of glucosamine hydrochloride and levocarnitine products, both in natural and monetary equivalents. Thus, the analysis of the data proves that the anabolic and frigoprotective properties of glucosamine have not received enough attention. The statistical data suggest that there is a growing market demand for levocarnitine for oral administration. Results: The ratio of the sales of glucosamine hydrochloride for injections and for oral use began to change when one of the Ukrainian drug manufacturers came out on the market with generic glucosamine hydrochloride for oral use. The changes in the price of one dose of glucosamine hydrochloride for oral use are due to the growth of the market share occupied by Ukrainian producers in this segment too. Such a shift in sales toward Ukrainian drugs contributes to the overall increase in the availability of drugs. Conclusions: Analysis of Ukrainian market of the glucosamine and levocarnitine preparations showed uneven distribution of foreign and domestic manufacturers.

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L-carnitine has a protective effect on the colonic mucosa during abdominopelvic radiotherapy in rats

Cited by 5 publications

References 29 publications

Protective effect of L-carnitine and vitamin E on gastrointestinal tract organs on male rats post radiation exposure

Protective effect of L-carnitine and vitamin E on gastrointestinal tract organs on male rats post radiation exposure

Changes in miRNA expressions in the injured small intestine of mice following high‑dose radiation exposure

Marketing Analysis of Levocarnitine and Glucosamine Preparations

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