2016
DOI: 10.1590/s0102-865020160070000005
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Abstract: PURPOSE:To investigate the protective effect of β-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice. METHODS:Animals(n=40) were randomly divided into four groups: (1)control, (2)IR, (3)MYR and (4)MYR+IR. The control group was received 0.1% carboxymethyl cellulose as a vehicle following a medial incision without carotid occlusion. In the IR group, the bilateral carotid arteries were clipped for 15min, and treated with the ve… Show more

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Cited by 21 publications
(8 citation statements)
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“…The anticarcinogenic properties of limonene were associated with gene expression alterations in apoptosis, signal transduction, DNA damage repair, and cell cycle regulation pathways [ 51 ]. Again, both antioxidative and antiproliferative potentials of pinene [ 52 , 53 ], myrcene [ 54 , 55 ], and 1,8-cineol [ 56 , 57 ] were reported by different researchers.…”
Section: Resultsmentioning
confidence: 99%
“…The anticarcinogenic properties of limonene were associated with gene expression alterations in apoptosis, signal transduction, DNA damage repair, and cell cycle regulation pathways [ 51 ]. Again, both antioxidative and antiproliferative potentials of pinene [ 52 , 53 ], myrcene [ 54 , 55 ], and 1,8-cineol [ 56 , 57 ] were reported by different researchers.…”
Section: Resultsmentioning
confidence: 99%
“…For Myrcene at least, engineered production at scale in bacteria may be possible [97]. It will also be important to assess the side effect and adverse effect profile of Myrcene [98][99][100][101][102] and to assign its documented effects in pain and other potential indications (ischemia/reperfusion injury [103], osteoarthritis [104], peptic ulcer [105], anti-oxidant [106]) to TRPV1 or other possible receptors. In this regard, network pharmacological analysis may be of assistance (see Supplemental Table III).…”
Section: Discussionmentioning
confidence: 99%
“…This volatile monoterpene showed potent antioxidant activity in the research of Ciftci et al [ 22 ]. Additionally, β-myrcene can be used for osteoarthritis treatment [ 23 ] and as an alternative treatment after ischemic stroke [ 24 ]. Limonene is also an outstanding monoterpene, which can be easily perceived by its citrusy smell.…”
Section: Discussionmentioning
confidence: 99%