2016
DOI: 10.1590/s0102-865020160060000008
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Abstract: PURPOSE:To investigate the protective effect of metformin on testicular ischemia/reperfusion (I/R) injury in rats. METHODS:Eighteen adult male Wistar rats were randomly divided into three experimental groups (n=6), as follows: Sham, I/R, and Metformin. 1-hour ischemia was induced by the left testicular artery and vein clipping followed by 7 days of reperfusion. Metformin (100 mg/kg) was administrated orally for 7 days via oral gavage after ischemic period. At the end of trial, the left testis was removed for h… Show more

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Cited by 31 publications
(27 citation statements)
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“…The ROS have destructive effects on various cellular components in the organism 24 . This may lead to molecular or genetic changes and pathologic features such as infertility 7 .…”
mentioning
confidence: 99%
“…The ROS have destructive effects on various cellular components in the organism 24 . This may lead to molecular or genetic changes and pathologic features such as infertility 7 .…”
mentioning
confidence: 99%
“…Ischaemia group has the highest score compared to the other groups (p < .001). Duration of ischaemia was 4 hr in our study whereas 1 hr in the previous studies using metformin (Asghari et al, 2016a). Each group consisted of eight rats per group The dose of metformin used was 100 mg/kg in two studies (Asghari et al, 2016a(Asghari et al, , 2016b and 300 mg/ml in the recent study (Ghasemnejad-Berenji, Ghazi-Khansari, Pashapour, et al, 2018;.…”
Section: F I G U R Ementioning
confidence: 82%
“…Each group consisted of eight rats per group The dose of metformin used was 100 mg/kg in two studies (Asghari et al, 2016a(Asghari et al, , 2016b and 300 mg/ml in the recent study (Ghasemnejad-Berenji, Ghazi-Khansari, Pashapour, et al, 2018;. Ischaemia/reperfusion with metformin (I/R + M) group had significantly lower score than I/R group (p < .001).…”
Section: F I G U R Ementioning
confidence: 99%
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“…Metformin, typically used to manage type II diabetes, may serve a role in alleviating inflammatory responses, which is beneficial in protecting the testes from tIR injury (64).…”
Section: Melanocortins (Mc)mentioning
confidence: 99%