2016
DOI: 10.1590/s0102-865020160040000009
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Abstract: Brazil. CNPq Researcher, level 1D. Scientific and intellectual content of the study; conception and design of the study; analysis and interpretation of data; statistical analysis; manuscript preparation and writing; critical revision; final approval. ABSTRACT PURPOSE:To investigate gender differences in the evolution of the inflammatory process in rats subjected to brain death (BD). METHODS:Adult Wistar rats were divided into three groups: female; ovariectomized female; and male rats. BD was induced using intr… Show more

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Cited by 9 publications
(8 citation statements)
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“…Furthermore, in the H&E slides, a semi-quantitative analysis of the inflammation was performed by an experienced pathologist to determine histopathological characteristics using the following scores: grade 0 (absent), 1 (discrete), 2 (mild), 3 (moderate) and 4 (intense) 48 , 49 .…”
Section: Methodsmentioning
confidence: 99%
“…Furthermore, in the H&E slides, a semi-quantitative analysis of the inflammation was performed by an experienced pathologist to determine histopathological characteristics using the following scores: grade 0 (absent), 1 (discrete), 2 (mild), 3 (moderate) and 4 (intense) 48 , 49 .…”
Section: Methodsmentioning
confidence: 99%
“…The biological processes that occur during brain death differ from those that unfold during cardiac death, and manifest in different potential insults to the lungs [14,15]. Additionally, females tend to exhibit a more robust innate immune response than males [16], and have been shown to demonstrate higher leukocyte counts compared with males in a rat model of brain death [17]. To account for these biological differences, NETs were analysed in the overall study cohort as well as by sex and donor type.…”
mentioning
confidence: 99%
“…Therefore, potential gender effects could have arisen, as previous studies showed differences in effects of brain death on IRI and microcirculation between sexes. 23,24 Moreover, even sex-dependent differences in the anticancer effects of metformin have been reported. 25 Whether this is also the case with metformin used in transplantation settings is worth elucidating.…”
Section: Metformin and Ir Injury During Kidney Perfusionmentioning
confidence: 99%