2016
DOI: 10.1590/s0102-865020160020000003
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Abstract: PURPOSE:The parotidectomy technique still has an elevated paresis and paralysis index, lowering patient life's quality. The correct identification of the facial nerve can prevent nerve damage. Fluorescent dye identifies nerves in experimental studies but only few articles focused its use on facial nerve study in parotidectomies. We aimed to stain the rat facial nerve with fluorescent dye to facilitate visualization and dissection in order to prevent injuries. METHODS:Forty adult male Wistar rats were submitted… Show more

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Cited by 8 publications
(3 citation statements)
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“…Prior studies in surgical fluorescent imaging have focused primarily upon the preservation of nerves and utilize contrast agents with varying nerve specificity 9 . For instance, a number of nerve-specific contrast agents have been developed, such as 4,4′-[(2-methoxy-1,4-phenylene)de-(1E)-2,1-ethenediyl]bis-benzenamine (BMB) and 4-[(1E)-2-[4-[(1E)-2-[4-aminophenyl]ethenyl]-3-methoxyphenyl]ethenyl]-benzonitrile (GE3082) which have been shown to help identify the sciatic nerve in porcine models as well as brachial plexus, sciatic, and trigeminal ganglia in rats 14 , 15 , 16 . The DOCI system does not require the use of contrast media as it is based upon the detection of fluorescence decay rates of endogenous fluorophores and thus avoids any potential toxicities that may be associated with labeling agents.…”
Section: Discussionmentioning
confidence: 99%
“…Prior studies in surgical fluorescent imaging have focused primarily upon the preservation of nerves and utilize contrast agents with varying nerve specificity 9 . For instance, a number of nerve-specific contrast agents have been developed, such as 4,4′-[(2-methoxy-1,4-phenylene)de-(1E)-2,1-ethenediyl]bis-benzenamine (BMB) and 4-[(1E)-2-[4-[(1E)-2-[4-aminophenyl]ethenyl]-3-methoxyphenyl]ethenyl]-benzonitrile (GE3082) which have been shown to help identify the sciatic nerve in porcine models as well as brachial plexus, sciatic, and trigeminal ganglia in rats 14 , 15 , 16 . The DOCI system does not require the use of contrast media as it is based upon the detection of fluorescence decay rates of endogenous fluorophores and thus avoids any potential toxicities that may be associated with labeling agents.…”
Section: Discussionmentioning
confidence: 99%
“…The use of fluorescent dyes has been shown to significantly improve intraoperative identification and preservation of the facial nerve during parotidectomy in both murine and rat models. 88,89 An injectable fluorescently labeled nerve binding probe, F-NP41, was also shown to aide in intraoperative visualization of transected facial nerves in a mouse model that had been denervated up to 9 months and decrease the amount of time required for nerve identification by 40% compared to surgeries performed under white light. 90 The potential for fluorescence guided surgery to improve surgical outcomes has subsequently been validated in humans and is currently being investigated in a multi-institutional phase I clinical trial of head and neck cancer patients.…”
Section: Use Of Fluorescent Dyes For Nerve Identificationmentioning
confidence: 99%
“…A study by Farrag et al [45] showed better recovery of whisker movement with the use of sutures in comparison to homologous fibrin sealant. In lesions of the terminal branches of the FN, the assessment of movement is one the methods used to confirm regeneration and proper restoration of damaged neural circuits, confirming appropriate integration with facial motor commands [42,[65][66][67].…”
Section: Groupsmentioning
confidence: 99%