Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

Abstract

. Design of the study, acquisition of data, critical revising and final approval of the version to be published. ABSTRACT PURPOSE:This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. METHODS:The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritional status, serum calprotectin and plasma Cu and Zn concentrations. Mann-Whitney U-test was performed between-group comparisons and Spearman correlation test for correlations between the variables. 1.35 (CI95% 1.23-1.46), p=0.01]were higher in patients with colorectal cancer than in controls. Additionally, the Cancer Group showed negative correlations between the Cu/Zn ratio and Zn intake, hemoglobin, serum albumin, and positive correlation between the Cu/Zn ratio and serum calprotectin. RESULTS: CONCLUSION:These results indicate that an increased plasma Cu/Zn ratio and serum calprotectin, and decreased protein values may be a result of the systemic inflammatory response to the tumor process.

Copper-to-Zinc Ratio Correlates with an Inflammatory Marker in Patients with Sickle Cell Disease (Version 1)

“…These micronutrients disturbances in response to inflammation may be contributing factors to a vicious cycle of impaired immune defense and higher risk of infection in susceptible individuals [16]. In a study which evaluated copper-to-zinc ratio and nutritional status in colorectal cancer patients during the perioperative period, it was observed that elevated copper-to-zinc ratio may be due to systemic inflammatory response to cancer [20]. Elevated copper-to-zinc ratio was considered as marker for asthma severity [21], renal disease among patients with peritoneal dialysis [22] and prostate cancer [23].…”

“…Elevated copper-to-zinc ratio was used as a diagnostic and prognostic marker of inflammation in lymphoma and leukemia, gastric and breast cancer. Higher copper-to-zinc ratio was significantly correlated with under-nutrition, oxidative stress, inflammation and depressed immune function [20,22]. An elevated copper-to-zinc ratio also correlated with elevated level of prostate specific antigen in subjects with prostate cancer [23] and lipid peroxidation in patients with asthma [21].…”

Marcadores inflamatórios em pacientes com neoplasia gástrica: níveis sanguíneos e expressão gênica

“…intestino (Federico et al, 2001) e em estágio avançados de câncergástrico (Seo et al, 2013). Os pacientes oncológicos que não foram submetidos à quimioterapia apresentaram maiores valores séricos de cobre, semelhante aos resultados encontrados com pacientes em préoperatório de neoplasia colorretal (Ribeiro et al, 2016). Cerca de90-95% do total de cobre circulante é ligado à ceruloplasmina (Tapiero et al, 2003), cujas concentrações são elevadas em resposta à inflamação, infecção e várias donças crônicas (Hordyjewska et al, 2014;Tapiero et al, 2003).…”

Marcadores inflamatórios de pacientes com neoplasia da confluência biliopancreática: níveis sanguíneos e expressão gênica

“…Nossos resultados não podem ser atribuídos à baixa ingestão alimentar, considerando que o consumo de zinco foi semelhante entre os grupos e dentro de faixa de recomendação. Os pacientes com câncer do presente estudo apresentaram maiores concentrações plasmáticas de cobre em relação aos controles, semelhante ao documentado em pacientes com neoplasia colorretal (Ribeiro et al, 2016). Aproximadamente 90-95% do total de cobre circulante é ligado à ceruloplasmina (Tapiero et al, 2003), cujas concentrações são elevadas em resposta à inflamação, infecção e várias donças crônicas (Hordyjewska et al, 2014;Tapiero et al, 2003).…”