2016
DOI: 10.1590/s0102-86502016001300004
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: PURPOSE: This paper describes the ability of miRNA value predict oncological outcomes in CRC patients and correlates to clinical and pathologic variables. METHODS:We prospectively analyzed the serological expression of microRNA-21, microRNA-34a, and microRNA-126 in 37 stage II -IV CRC patients and correlate to seven fit counterparts. Serological microRNAs were extracted using the miRNeasy Mini Kit® (Qiagen, Hilden, Germany). Quantification of microRNAs was performed using TaqMan Master Mix® reagent (Applied Bi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
15
0
1

Year Published

2016
2016
2021
2021

Publication Types

Select...
8
1
1

Relationship

1
9

Authors

Journals

citations
Cited by 23 publications
(16 citation statements)
references
References 28 publications
0
15
0
1
Order By: Relevance
“…Recently, several papers have reported the usefulness of plasma/serum miR-21 levels as a biomarker for diagnosis in CRC patients [23,24,25,26,27,28]. However, the clinical significance of plasma/serum miRNA as a biomarker for diagnosis is still controversial, and some papers have indicated that serological miR-21 does not have any impact on diagnosis in CRC patients [29,30]. One reason for this controversy may be the instability of miRNA in plasm/serum.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, several papers have reported the usefulness of plasma/serum miR-21 levels as a biomarker for diagnosis in CRC patients [23,24,25,26,27,28]. However, the clinical significance of plasma/serum miRNA as a biomarker for diagnosis is still controversial, and some papers have indicated that serological miR-21 does not have any impact on diagnosis in CRC patients [29,30]. One reason for this controversy may be the instability of miRNA in plasm/serum.…”
Section: Discussionmentioning
confidence: 99%
“…A biotinylated circ_0060745 probe was designed and incubated with lysates from HT29 and LOVO cells. Pulled-down miR-4736 was measured using qRT-PCR by using of miR-577 and miR-126 (two previously identified metastasis-related miRNAs in CRC 19,25,26 ) as corresponding control. As shown in Figure 4B and C, miR-4736 was pulled down by circ_0060745.…”
Section: Circular Rna 0060745 Promoted Proliferation and Metastasis Vmentioning
confidence: 99%
“…miR-34a, a member of the miR-34 family, is one of the first miRNAs to display tumor suppressive activity. It was down-regulated in several cancer types including chronic lymphocytic leukemia42, colorectal cancer43, lung cancer44 and MM19. Moreover, recent researches have focused on its functions in modulating immune response as a putative binder of PD-L1-3′ UTR45.…”
Section: Discussionmentioning
confidence: 99%