Analysis of the healing process of the wounds occurring in rats using lasertherapy in association with hydrocolloid

Abstract

PURPOSE:To evaluate wound healing in rats by using low-level laser therapy (LLLT) associated with hydrocolloid occlusive dressing. METHODS:Forty male, adult, Wistar rats were used, distributed into four groups: LG (received 2 J/cm² of laser therapy); HG (treated with hydrocolloid); LHG (treated with 2 J/cm² of laser therapy and hydrocolloid); and the CG (treated with 1 mL of 0.9% saline).The wound was evaluated at pre-determined periods 3rd and 7th days, considering the macroscopic and histological parameters (inflammatory cells, capillary neoformation, fibroblasts, collagen formation and reepithelialization). RESULTS:The LG group at seven days showed increased collagen formation, the LHG group at 3 days showed mild collagen formation. The HG group and the CG at 7 days showed complete reepithelialization. CONCLUSION:Low-level laser therapy as well as the hydrocolloid dressing have favored the wound-healing process in rats.

Effects of herbal ointment containing the leaf extracts of Madeira vine (Anredera cordifolia (Ten.) Steenis) for burn wound healing process on albino rats

“…Humidity was one of the conditions affected the wound healing process. Humidity has a permeability character with oxygen and water vapor, but it is occlusive against bacteria and water, so the healing process is not affected [ 18 ]. Oxygen is a vital nutrition for cell metabolism and is extremely required in wound healing process [ 19 ].…”

Efeitos da fotobiomodulação (laser de baixa intensidade) na cicatrização de feridas: revisão integrativa

“…Observou-se nessa revisão uma diferença na densidade de energia utilizada, bem como na frequência de utilização e na potência. Densidades de energia variaram de 1 a 20 J/cm 2 , sendo a mais utilizada a de 4J/cm 2 (Barbosa et al, 2020;Feitosa et al, 2015;Cunha et al, 2019;Taradaj et al 2018), 5J/cm 2 (Atasoy et al, 2017;Sousa et al, 2015;Cunha et al, 2019) (Nilforoushzadeh et al, 2019;Fioruzi et al, 2018;, 2J/cm 2 (Martins et al, 2015), 3J/cm 2 (Scherer et al 2019;De Souza et al, 2018), 0,25 J/cm 2 (Barbosa et al, 2020), 10 J/cm 2 e 20 J/cm 2 (Atasoy et al, 2017) e 8J/cm 2 ( Sousa et al, 2015). Observou-se, quanto aos parâmetros de aplicação da FBM, que eles variaram de 632,8 a 940 nm, mas a maior parte dos estudos (12= 75%) utilizou entre 632,8 a 670 nm, demonstrando uma padronização na utilização nas feridas.…”

“…Identificou-se que diversos estudos associaram a FBM a outras terapias tópicas utilizadas para cicatrização de feridas (Carvalho et al, 2016;Martins et al, 2015;Nilforoushzadeh et al, 2019;Fioruzi et al, 2018).…”

“…Já com o uso de hidrocolóide colocado em ratos com feridas cutâneas, não houve uma diferença de resultados na cicatrização quando associado à FBM. Porém, foi observado que os ratos ficaram mais calmos, provavelmente por diminuição da dor (Martins et al, 2015).…”

Hydrogel plus growth factors treatment after 2940nm erbium:YAG lattice laser improves periorbital wrinkles and wound healing: a case report

“…8 Furthermore, wound care with GFs or HG can accelerate epithelial regeneration and the wound healing process. [2][3][4] Previous research has indicated that wound dressing plus GFs, compared with wound dressing alone, showed more therapeutical benefits after laser treatment. 2 However, treatment with GFs exhibits limited curative effects because they are rapidly degraded, having only a short half-life.…”