2015
DOI: 10.1590/s0102-865020150090000007
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Abstract: PURPOSE:To assess whether deoxycholic acid (DOC) and lithocholic acid (LCA) administered in a period of six months in a concentration of 0.25% may have a carcinogenic role in mice colon. METHODS:The study used C57BL6 female mice divided into four groups. The control group received a balanced diet and the others received diets supplemented with 0.25% DOC, 0.25% LCA and 0.125% DOC+0.125% LCA, respectively. After euthanasia, the lesions found in the resected gastrointestinal tracts were stained with hematoxylin-e… Show more

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Cited by 15 publications
(16 citation statements)
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References 19 publications
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“…Other explanation might be that cells in the surface can be affected by alterations in the intestinal contents delivered from the small intestine into the colon. For example, bile acids are known to induce colitis in mice and humans [34, 35], and even when there is no available data for fecal bile acid contents in RTT patients or animal models, scattered reports of RTT patients hospitalized due to liver failure and many others subjected to gallbladder removal are available [27]. More recently, it has been published that Rett patients presented with a less diverse microbiota than healthy subjects [36], which could affect gastrointestinal function, but this possibility has not been explored in the mouse model yet.…”
Section: Discussionmentioning
confidence: 99%
“…Other explanation might be that cells in the surface can be affected by alterations in the intestinal contents delivered from the small intestine into the colon. For example, bile acids are known to induce colitis in mice and humans [34, 35], and even when there is no available data for fecal bile acid contents in RTT patients or animal models, scattered reports of RTT patients hospitalized due to liver failure and many others subjected to gallbladder removal are available [27]. More recently, it has been published that Rett patients presented with a less diverse microbiota than healthy subjects [36], which could affect gastrointestinal function, but this possibility has not been explored in the mouse model yet.…”
Section: Discussionmentioning
confidence: 99%
“…For many years, a high level of deoxycholic acid (DCA, a secondary bile acid) in the intestinal lumen, mostly induced by a high dietary fat intake, was proposed as a potential pro‐carcinogenic agent . Persistent and repeated exposure of intestinal epithelium to abnormally high concentrations of DCA appears to induce DNA damage and genomic instability .…”
Section: Introductionmentioning
confidence: 99%
“…For many years, a high level of deoxycholic acid (DCA, a secondary bile acid) in the intestinal lumen, mostly induced by a high dietary fat intake, was proposed as a potential procarcinogenic agent. [9][10][11] Persistent and repeated exposure of intestinal epithelium to abnormally high concentrations of DCA appears to induce DNA damage and genomic instability. 12 Several epidemiological studies have highlighted the correlation between high physiologic levels of DCA and incidence of CRC, 13,14 although the mechanisms remain elusive.…”
Section: Introductionmentioning
confidence: 99%
“…This may be because high fat diet leads to an increase in intestinal primary bile acid secretion, while microbiota can transform this primary bile acid metabolism into secondary bile acid. When researchers fed mice with secondary bile acids, intestinal tumor formation and inflammatory damage were greatly increased [22]. It is found that this kind of bile acid can be used as the source of microbial energy, and promote the development of CRC by participating in cell proliferation, apoptosis, and DNA damage [23].…”
Section: Gut Microbial Metabolitesmentioning
confidence: 99%