2015
DOI: 10.1590/s0102-865020150080000002
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Abstract: PURPOSE:To investigate the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) after subcutaneous injection of dexamethasone prior to skin incision in rats. METHODS:Twenty seven Wistar-EPM-1 rats were randomly divided into three groups. The sham group (SG) of rats was injected with 0.9 % saline. The second group (Dexa) was injected with 1.0 mg/kg dexamethasone, and the third group (Dexa+) was injected with 10.0 mg/kg dexamethasone. In all groups, the three subcutaneous injections were per… Show more

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Cited by 3 publications
(3 citation statements)
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References 29 publications
(24 reference statements)
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“…Glucocorticoids acute treatment also increases leptin levels in overweight women, 37 but did not affect plasma leptin levels in healthy non‐diabetic male, 39 indicating gender and metabolic parameters may interfere with its effects. Finally, dexamethasone does not inhibit SP in experimental skin neurogenic inflammation, 40 but inhibits SP expression in human cells during chronic tendinopathy, 41 making it hard to establish a position about its role in SP levels. Dipyrone was the only non‐opioid analgesic drug used in patients during the hospitalization period.…”
Section: Discussionmentioning
confidence: 99%
“…Glucocorticoids acute treatment also increases leptin levels in overweight women, 37 but did not affect plasma leptin levels in healthy non‐diabetic male, 39 indicating gender and metabolic parameters may interfere with its effects. Finally, dexamethasone does not inhibit SP in experimental skin neurogenic inflammation, 40 but inhibits SP expression in human cells during chronic tendinopathy, 41 making it hard to establish a position about its role in SP levels. Dipyrone was the only non‐opioid analgesic drug used in patients during the hospitalization period.…”
Section: Discussionmentioning
confidence: 99%
“…When exposed to exogenous stimuli, Ca 2+ flows into the neurons, releasing calcitonin gene‐related peptide (CGRP) and causing hemangiectasis. CGRP is an inflammatory prion that activates mast cells, macrophages, fibroblasts, melanocytes, keratinocytes, dendritic cells, and lymphocytes B and T, thereby promoting the development of oedema induced by IL‐1 and IL‐8 . Fluorescence identification test of CGRP quantity as pre‐inflammatory neurotransmitters can be used to evaluate the signal transduction of neurons, thereby showing the nerve sedation effect under stimulation.…”
Section: Efficacy Evaluation Methods For Anti‐sensitive Ingredientsmentioning
confidence: 99%
“…Neurogenic inflammation is a phenomenon of reduced sensory nerve thresholds and increased activation of sensory neurons, induced by excitation of nociceptors following the stimulation of pain mediators [42]. Therefore, pain relief after BoNT injections in chronic shoulder joint pain might be attributed to the interference of afferent pain signals and modulation of neurogenic inflammation, which could not be achieved by the administration of corticosteroids [43].…”
Section: Botulinum Toxin (Bont) Injection In Shoulder Joint Painmentioning
confidence: 99%