Is it possible folic acid reduce anorectal malformations ethylenethiourea induced in rats?

Faria, Danilo José Fiorindo; Simões, Manuel de Jesus; Martins, José Luiz

doi:10.1590/s0102-865020150080000001

Cited by 10 publications

(8 citation statements)

References 23 publications

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“…Our meta-analysis, however, could not show any association with ARM. In contrast, the study by Faria et al [ 88 ] observed in their experimental model a reducing effect in the incidence of ARM when inducing ethylenethiourea in rats.…”

Section: Discussionmentioning

confidence: 74%

Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis

Zwink

Jenetzky

2018

Orphanet J Rare Dis

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BackgroundOrigin of anorectal malformations (ARM) are considered multifactorial. Several genetic and non-genetic risk factors are discussed in literature. Maternal periconceptional medical drug use as possible risk factor, however, has not been reviewed systematically.MethodsStudies published between 1977 and April 2017 were reviewed through systematic search in PubMed, ISI Web of Knowledge and Scopus databases. Furthermore, related and cross-referencing publications were reviewed. Pooled odds ratios (95% confidence intervals) were determined to quantify associations of maternal periconceptional use of folic acid, multivitamins, anti-asthma medication (separated in any anti-asthma medication, inhaled corticosteroids and salbutamol), thyroid hormone supplements, psychiatric drugs (separated in antidepressants, any selective serotonin reuptake inhibitors [SSRI], sertraline, citalopram, fluoxetine, paroxetine, hypnotics and benzodiazepine) and aspirin with ARM using meta-analyses.ResultsThirty-seven studies that reported on the association between maternal periconceptional drug intake and infants born with ARM were included in this review. These were conducted in the United States of America (n = 14), Sweden (n = 6), Hungary (n = 5), Germany (n = 3), the Netherlands (n = 3), Denmark (n = 2), France (n = 2), Norway (n = 1) and the UK (n = 1). However, only few of these studies reported on the same risk factors. Studies were heterogeneous with respect to case numbers, period ingestion of medical drug use, control selection and adjustment for covariates. Consistently increased risks were observed for any anti-asthma medication, and hypnotics and benzodiazepine, but not for folic acid, multivitamins, inhaled corticosteroids, salbutamol, thyroid hormone supplements, antidepressants, any SSRI, sertraline, citalopram, fluoxetine, paroxetine and aspirin. In meta-analyses, pooled odds ratios (95% confidence intervals) for any anti-asthma medication, and hypnotics and benzodiazepine were 1.64 (1.22–2.21), and 2.43 (1.03–5.73), respectively.ConclusionEvidence on maternal drug use before conception and during pregnancy as risk factor for ARM from epidemiological studies is still very limited. Nevertheless, the few available studies indicate any anti-asthma medication, and hypnotics and benzodiazepine to be associated with increased risks. Further, ideally large-scale multicenter and register-based studies are needed to clarify the role of maternal drug intake for the development of ARM.

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Section: Discussionmentioning

confidence: 74%

Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis

Zwink

Jenetzky

2018

Orphanet J Rare Dis

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“…Furthermore, coadministration of both drugs significantly minimized similarly the hazards of AZA on the fetal development. At the same direction, folic acid reduces the incidence of anorectal malformations induced by ethylenethiourea in rats (Faria et al, 2015). Micronutrients like folic acid and vitamin B12 are important determinants of the one carbon cycle and play a critical role in determining pregnancy outcome (Gadgil et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Folic Acid and Grape Seed Extract Prevent Azathioprine‐induced Fetal Malformations and Renal Toxicity in Rats

El-Ashmawy

Bayad

2016

Phytotherapy Research

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Azathioprine (AZA) is an important drug commonly used in the therapy of the autoimmune system disorders. It induces many hazard effects that restrict its use. The present study was designed to investigate the influence of AZA on the fetal development and renal function and its co-administration with either folic acid (FA) or grape seed extract (GSE). The effects of administration of GSE or FA on AZA toxicity by gavage simultaneously for 4 weeks were studied by determining the changes in kidney histology, the glutathione level (GSH), and lipid per oxidation content as malondialdehyde in the kidney tissue. Additionally, their effects on the fetal development were investigated. Azathioprine induced a renal damage as indicated from the pronounced changes in histological structure, a significant increase in serum urea and creatinine, and malondialdehyde content in the kidney tissue. Meanwhile, the GSH activity was significantly decreased. Co-treatment with GSE significantly minimized the previously mentioned hazard effects of AZA by ameliorating the antioxidant activity. At this point, FA induced a nonsignificant protective activity. The results also revealed that administration of FA or GSE at 6th to 15th day of gestation did not altered fetal development. While, AZA administration clearly disturbed fetal development as indicated from a significant decrease in fetal weights. Furthermore, co-administration of both drugs significantly minimized similarly the hazards of AZA on the fetal development. It may be concluded that GSE and FA are a useful remedies. Maternal administrations of either both are protective agents against AZA-induced fetal malformations. Grape seed extract was more active than FA in potentiating the antioxidative defenses for controlling AZA-induced oxidative renal damages. Copyright © 2016 John Wiley & Sons, Ltd.

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“…The conclusion of the study was that the FA (received daily, for 2 weeks before pregnancy until the end of pregnancy) reduces the incidence of ARM induced by ETU in rats. 32 Using a modified experimental model of ARM (adriamycin induced in rats), the effect of FA to prevent the induction of ARM was studied. 33 The results demonstrate that the use of FA reduces the numbers of ARM and enlarged the thickness of intestinal epithelium when compared with the controls.…”

Section: Introductionmentioning

confidence: 99%

Anorectal Malformation: State of the Art in Translating Experimental Research to the Bedside

2019

Self Cite

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The embryology of anorectal malformation (ARM) is a controversial issue. The study in humans is difficult due to the scarcity of fetuses with this anomaly. Therefore, ARM animal models, naturally obtained or induced by drugs, have been employed to understand physiopathology and possible treatments. Pigs, rabbits, rats, and mice have been employed as animal models. Additionally, many drugs have been used with this purpose: Etretinate, Ethylenethiourea, and Adriamycin. The animal more frequently used is the rat because of good reproducibility, low cost, and easy handling. Pig is a good model, but it is expensive, and difficult to handling and lodging. Concerning the drugs, Adriamycin promotes a more severe ARM compared with Ethylenethiourea. The models of ARM are of value in the understanding of the embryologic development. Nowadays, researches are aimed at identifying the molecular mechanism of this process, providing the basis for the application of tissue engineering in future experiments with ARM.

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Is it possible folic acid reduce anorectal malformations ethylenethiourea induced in rats?

Cited by 10 publications

References 23 publications

Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis

Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis

Folic Acid and Grape Seed Extract Prevent Azathioprine‐induced Fetal Malformations and Renal Toxicity in Rats

Anorectal Malformation: State of the Art in Translating Experimental Research to the Bedside

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